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Dietary folate intake and pancreatic cancer risk : Results from the European prospective investigation into cancer and nutrition

Park, Jin Young ; Bueno-de-Mesquita, H. Bas ; Ferrari, Pietro ; Weiderpass, Elisabete ; de Batlle, Jordi ; Tjønneland, Anne ; Kyro, Cecilie ; Rebours, Vinciane ; Boutron-Ruault, Marie Christine and Mancini, Francesca Romana , et al. (2019) In International Journal of Cancer 144(7). p.1511-1521
Abstract

Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age,... (More)

Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (<241 μg/day) was 0.81 (95% CI: 0.51, 1.31; ptrend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. <241 μg/day, ptrend = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (pinteraction = 0.99). We found no association between dietary folate intake and PC risk in this large European study.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dietary folate intake, EPIC study, pancreatic cancer
in
International Journal of Cancer
volume
144
issue
7
pages
1511 - 1521
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85058931652
  • pmid:30178496
ISSN
0020-7136
DOI
10.1002/ijc.31830
language
English
LU publication?
yes
id
fb6717c1-d1e1-479f-b45d-2c2f41d7e084
date added to LUP
2019-01-14 13:47:19
date last changed
2023-09-18 13:23:47
@article{fb6717c1-d1e1-479f-b45d-2c2f41d7e084,
  abstract     = {{<p>Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (&lt;241 μg/day) was 0.81 (95% CI: 0.51, 1.31; p<sub>trend</sub> = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. &lt;241 μg/day, p<sub>trend</sub> = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (p<sub>interaction</sub> = 0.99). We found no association between dietary folate intake and PC risk in this large European study.</p>}},
  author       = {{Park, Jin Young and Bueno-de-Mesquita, H. Bas and Ferrari, Pietro and Weiderpass, Elisabete and de Batlle, Jordi and Tjønneland, Anne and Kyro, Cecilie and Rebours, Vinciane and Boutron-Ruault, Marie Christine and Mancini, Francesca Romana and Katzke, Verena and Kühn, Tilman and Boeing, Heiner and Trichopoulou, Antonia and La Vecchia, Carlo and Kritikou, Maria and Masala, Giovanna and Pala, Valeria and Tumino, Rosario and Panico, Salvatore and Peeters, Petra H. and Skeie, Guri and Merino, Susana and Duell, Eric J. and Rodríguez-Barranco, Miguel and Dorronsoro, Miren and Chirlaque, Maria Dolores and Ardanaz, Eva and Gylling, Björn and Schneede, Jörn and Ericson, Ulrika and Sternby, Hanna and Khaw, Kay Tee and Bradbury, Kathryn E. and Huybrechts, Inge and Aune, Dagfinn and Vineis, Paolo and Slimani, Nadia}},
  issn         = {{0020-7136}},
  keywords     = {{dietary folate intake; EPIC study; pancreatic cancer}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1511--1521}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Dietary folate intake and pancreatic cancer risk : Results from the European prospective investigation into cancer and nutrition}},
  url          = {{http://dx.doi.org/10.1002/ijc.31830}},
  doi          = {{10.1002/ijc.31830}},
  volume       = {{144}},
  year         = {{2019}},
}