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A 76-year-old man with cognitive and neurological symptoms

Brunnström, Hans LU ; Dictor, Michael LU ; Nilsson, Christer LU ; Gülich, Dag and Englund, Elisabet LU (2009) In Brain Pathology 19(4). p.4-731
Abstract

A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be... (More)

A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be difficult to diagnose, even histologically, due to their frequent small cell morphology and lack of significant atypia.

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published
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keywords
Aged, Aphasia, Brain Neoplasms, Fatal Outcome, Frontal Lobe, Humans, Immunohistochemistry, Lymphoma, T-Cell, Magnetic Resonance Imaging, Male, Memory Disorders, Staining and Labeling, Case Reports, Letter
in
Brain Pathology
volume
19
issue
4
pages
4 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:69949150255
ISSN
1750-3639
DOI
10.1111/j.1750-3639.2009.00311.x
language
English
LU publication?
yes
id
fb7b3a91-34c6-4e96-bf97-d54a50dd4275
date added to LUP
2017-07-13 09:52:44
date last changed
2017-08-07 16:53:12
@article{fb7b3a91-34c6-4e96-bf97-d54a50dd4275,
  abstract     = {<p>A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be difficult to diagnose, even histologically, due to their frequent small cell morphology and lack of significant atypia.</p>},
  author       = {Brunnström, Hans and Dictor, Michael and Nilsson, Christer and Gülich, Dag and Englund, Elisabet},
  issn         = {1750-3639},
  keyword      = {Aged,Aphasia,Brain Neoplasms,Fatal Outcome,Frontal Lobe,Humans,Immunohistochemistry,Lymphoma, T-Cell,Magnetic Resonance Imaging,Male,Memory Disorders,Staining and Labeling,Case Reports,Letter},
  language     = {eng},
  number       = {4},
  pages        = {4--731},
  publisher    = {Wiley-Blackwell},
  series       = {Brain Pathology},
  title        = {A 76-year-old man with cognitive and neurological symptoms},
  url          = {http://dx.doi.org/10.1111/j.1750-3639.2009.00311.x},
  volume       = {19},
  year         = {2009},
}