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A 76-year-old man with cognitive and neurological symptoms

Brunnström, Hans LU orcid ; Dictor, Michael LU ; Nilsson, Christer LU ; Gülich, Dag and Englund, Elisabet LU orcid (2009) In Brain Pathology 19(4). p.4-731
Abstract

A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be... (More)

A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be difficult to diagnose, even histologically, due to their frequent small cell morphology and lack of significant atypia.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Aphasia, Brain Neoplasms, Fatal Outcome, Frontal Lobe, Humans, Immunohistochemistry, Lymphoma, T-Cell, Magnetic Resonance Imaging, Male, Memory Disorders, Staining and Labeling, Case Reports, Letter
in
Brain Pathology
volume
19
issue
4
pages
4 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:69949150255
  • pmid:19744045
ISSN
1750-3639
DOI
10.1111/j.1750-3639.2009.00311.x
language
English
LU publication?
yes
id
fb7b3a91-34c6-4e96-bf97-d54a50dd4275
date added to LUP
2017-07-13 09:52:44
date last changed
2024-01-14 00:40:38
@article{fb7b3a91-34c6-4e96-bf97-d54a50dd4275,
  abstract     = {{<p>A 76-year-old man presented with cognitive symptoms, followed by headache and weakness of the lower limbs and left arm. The clinical course was progressive but fluctuating. On magnetic resonance imaging (MRI), a contrast-enhancing lesion 1 cm in diameter was seen in the left temporal lobe. This lesion became attenuated and a new contrast-enhancing lesion 1 x 2 cm was seen in the left frontal lobe on a subsequent MRI. Following additional tests, treatment with corticosteroids for presumptive neurosarcoidosis was started, however, he soon expired. At autopsy, there was a tumor-like mass in the left frontal lobe. Pathologic evaluation revealed a primary T-cell lymphoma of the central nervous system (CNS). CNS T-cell lymphomas may be difficult to diagnose, even histologically, due to their frequent small cell morphology and lack of significant atypia.</p>}},
  author       = {{Brunnström, Hans and Dictor, Michael and Nilsson, Christer and Gülich, Dag and Englund, Elisabet}},
  issn         = {{1750-3639}},
  keywords     = {{Aged; Aphasia; Brain Neoplasms; Fatal Outcome; Frontal Lobe; Humans; Immunohistochemistry; Lymphoma, T-Cell; Magnetic Resonance Imaging; Male; Memory Disorders; Staining and Labeling; Case Reports; Letter}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{4--731}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Brain Pathology}},
  title        = {{A 76-year-old man with cognitive and neurological symptoms}},
  url          = {{http://dx.doi.org/10.1111/j.1750-3639.2009.00311.x}},
  doi          = {{10.1111/j.1750-3639.2009.00311.x}},
  volume       = {{19}},
  year         = {{2009}},
}