Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Pregnancy Outcomes in Women Screened for Tuberculosis Infection in Swedish Antenatal Care

Walles, John LU orcid ; Winqvist, Niclas LU ; Hansson, Stefan R. LU orcid ; Sturegård, Erik LU ; Baqir, Haitham ; Westman, Anna ; Kjerstadius, Torbjörn ; Schön, Thomas and Björkman, Per LU orcid (2024) In Clinical Infectious Diseases 78(1). p.125-132
Abstract

Background: Tuberculosis (TB) disease has been associated with pregnancy complications. However, the potential impact of TB infection (TBI) on pregnancy outcome is unknown. To investigate this, we conducted a register-based study in immigrant women screened with QuantiFERON assays for TBI in antenatal care in Sweden. Methods: Women with history of immigration from TB-endemic countries were eligible for inclusion if national identification numbers and available QuantiFERON results obtained during pregnancy from 2014 to 2018 were available. QuantiFERON results were linked to data on maternal characteristics and pregnancy outcomes from the national Pregnancy and Patient Registers. TBI was defined as nil-corrected QuantiFERON result ≥0.35... (More)

Background: Tuberculosis (TB) disease has been associated with pregnancy complications. However, the potential impact of TB infection (TBI) on pregnancy outcome is unknown. To investigate this, we conducted a register-based study in immigrant women screened with QuantiFERON assays for TBI in antenatal care in Sweden. Methods: Women with history of immigration from TB-endemic countries were eligible for inclusion if national identification numbers and available QuantiFERON results obtained during pregnancy from 2014 to 2018 were available. QuantiFERON results were linked to data on maternal characteristics and pregnancy outcomes from the national Pregnancy and Patient Registers. TBI was defined as nil-corrected QuantiFERON result ≥0.35 IU/mL, in the absence of TB disease. Pregnancies in women with TB disease or human immunodeficiency virus were excluded, as were multiplex pregnancies, pregnancies resulting in miscarriage, and pregnancies occurring >10 years after immigration. Odds of defined adverse pregnancy outcomes were compared by maternal TBI status using mixed effects logistic regression with adjustment for maternal age and region of origin. Results: In total, 7408 women with 12 443 pregnancies were included. In multivariable analysis, stillbirth (adjusted odds ratio [AOR], 1.90; 95% confidence interval [CI], 1.13-3.21; P =. 016), severe preeclampsia (AOR, 1.62; 95% CI, 1.03-2.56; P =. 036), low birthweight (<2500 g; AOR, 1.38; 95% CI, 1.01-1.88; P =. 041), and emergency cesarean section (AOR, 1.28; 95% CI, 1.02-1.63; P =. 033) were significantly associated with TBI. Conclusions: Among immigrant women seeking antenatal care in Sweden, TBI was independently associated with adverse pregnancy outcomes. Further studies are needed to corroborate these findings and to explore mechanisms involved.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
latent tuberculosis infection, preeclampsia, pregnancy, stillbirth, tuberculosis
in
Clinical Infectious Diseases
volume
78
issue
1
pages
8 pages
publisher
Oxford University Press
external identifiers
  • pmid:37572363
  • scopus:85183651129
ISSN
1058-4838
DOI
10.1093/cid/ciad465
language
English
LU publication?
yes
id
fc5a6d1a-3f98-4634-8e72-803bed17c7da
date added to LUP
2024-02-26 11:38:07
date last changed
2024-04-25 19:28:43
@article{fc5a6d1a-3f98-4634-8e72-803bed17c7da,
  abstract     = {{<p>Background: Tuberculosis (TB) disease has been associated with pregnancy complications. However, the potential impact of TB infection (TBI) on pregnancy outcome is unknown. To investigate this, we conducted a register-based study in immigrant women screened with QuantiFERON assays for TBI in antenatal care in Sweden. Methods: Women with history of immigration from TB-endemic countries were eligible for inclusion if national identification numbers and available QuantiFERON results obtained during pregnancy from 2014 to 2018 were available. QuantiFERON results were linked to data on maternal characteristics and pregnancy outcomes from the national Pregnancy and Patient Registers. TBI was defined as nil-corrected QuantiFERON result ≥0.35 IU/mL, in the absence of TB disease. Pregnancies in women with TB disease or human immunodeficiency virus were excluded, as were multiplex pregnancies, pregnancies resulting in miscarriage, and pregnancies occurring &gt;10 years after immigration. Odds of defined adverse pregnancy outcomes were compared by maternal TBI status using mixed effects logistic regression with adjustment for maternal age and region of origin. Results: In total, 7408 women with 12 443 pregnancies were included. In multivariable analysis, stillbirth (adjusted odds ratio [AOR], 1.90; 95% confidence interval [CI], 1.13-3.21; P =. 016), severe preeclampsia (AOR, 1.62; 95% CI, 1.03-2.56; P =. 036), low birthweight (&lt;2500 g; AOR, 1.38; 95% CI, 1.01-1.88; P =. 041), and emergency cesarean section (AOR, 1.28; 95% CI, 1.02-1.63; P =. 033) were significantly associated with TBI. Conclusions: Among immigrant women seeking antenatal care in Sweden, TBI was independently associated with adverse pregnancy outcomes. Further studies are needed to corroborate these findings and to explore mechanisms involved.</p>}},
  author       = {{Walles, John and Winqvist, Niclas and Hansson, Stefan R. and Sturegård, Erik and Baqir, Haitham and Westman, Anna and Kjerstadius, Torbjörn and Schön, Thomas and Björkman, Per}},
  issn         = {{1058-4838}},
  keywords     = {{latent tuberculosis infection; preeclampsia; pregnancy; stillbirth; tuberculosis}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{125--132}},
  publisher    = {{Oxford University Press}},
  series       = {{Clinical Infectious Diseases}},
  title        = {{Pregnancy Outcomes in Women Screened for Tuberculosis Infection in Swedish Antenatal Care}},
  url          = {{http://dx.doi.org/10.1093/cid/ciad465}},
  doi          = {{10.1093/cid/ciad465}},
  volume       = {{78}},
  year         = {{2024}},
}