High disaccharide intake associates with atherogenic lipoprotein profile.
(2012) In British Journal of Nutrition 107. p.1062-1069- Abstract
- Increased plasma concentrations of small LDL particles denote an atherogenic lipoprotein phenotype (ALP) that is correlated with increased circulating TAG and reduced HDL-cholesterol. Principal component analyses of subfraction concentrations have previously been used in the Swedish population-based Malmö Diet and Cancer (MDC) cohort to identify three independent components, one pattern representing the ALP. The aim of the present study was to examine the associations between macronutrient intakes and the principal component representing the ALP. We examined 4301 healthy subjects (46-68 years old, 60 % women) at baseline in the MDC cohort. Dietary data were collected using a modified diet history method. Plasma lipoprotein subfractions... (More)
- Increased plasma concentrations of small LDL particles denote an atherogenic lipoprotein phenotype (ALP) that is correlated with increased circulating TAG and reduced HDL-cholesterol. Principal component analyses of subfraction concentrations have previously been used in the Swedish population-based Malmö Diet and Cancer (MDC) cohort to identify three independent components, one pattern representing the ALP. The aim of the present study was to examine the associations between macronutrient intakes and the principal component representing the ALP. We examined 4301 healthy subjects (46-68 years old, 60 % women) at baseline in the MDC cohort. Dietary data were collected using a modified diet history method. Plasma lipoprotein subfractions were measured using a high-resolution ion mobility method. The principal component corresponding to the ALP was significantly associated with a higher intake of disaccharides, and inversely related to protein and alcohol consumption (P < 0·001 for all). The present findings indicate that the ALP may be improved by a low intake of disaccharides, and moderate intakes of protein and alcohol. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2200366
- author
- organization
-
- Nutrition Epidemiology (research group)
- Diabetes - Cardiovascular Disease (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- Cardiovascular Research - Epidemiology (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- British Journal of Nutrition
- volume
- 107
- pages
- 1062 - 1069
- publisher
- Cambridge University Press
- external identifiers
-
- wos:000304126500015
- pmid:22011476
- scopus:84861448898
- ISSN
- 1475-2662
- DOI
- 10.1017/S0007114511003783
- language
- English
- LU publication?
- yes
- id
- fd38a4f8-c537-477d-aba3-0ffa89a73cfd (old id 2200366)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22011476?dopt=Abstract
- date added to LUP
- 2016-04-04 08:46:27
- date last changed
- 2022-02-13 06:42:33
@article{fd38a4f8-c537-477d-aba3-0ffa89a73cfd, abstract = {{Increased plasma concentrations of small LDL particles denote an atherogenic lipoprotein phenotype (ALP) that is correlated with increased circulating TAG and reduced HDL-cholesterol. Principal component analyses of subfraction concentrations have previously been used in the Swedish population-based Malmö Diet and Cancer (MDC) cohort to identify three independent components, one pattern representing the ALP. The aim of the present study was to examine the associations between macronutrient intakes and the principal component representing the ALP. We examined 4301 healthy subjects (46-68 years old, 60 % women) at baseline in the MDC cohort. Dietary data were collected using a modified diet history method. Plasma lipoprotein subfractions were measured using a high-resolution ion mobility method. The principal component corresponding to the ALP was significantly associated with a higher intake of disaccharides, and inversely related to protein and alcohol consumption (P < 0·001 for all). The present findings indicate that the ALP may be improved by a low intake of disaccharides, and moderate intakes of protein and alcohol.}}, author = {{Sonestedt, Emily and Wirfält, Elisabet and Wallström, Peter and Gullberg, Bo and Drake, Isabel and Hlebowicz, Joanna and Nordin Fredrikson, Gunilla and Hedblad, Bo and Nilsson, Jan and Krauss, Ronald M and Orho-Melander, Marju}}, issn = {{1475-2662}}, language = {{eng}}, pages = {{1062--1069}}, publisher = {{Cambridge University Press}}, series = {{British Journal of Nutrition}}, title = {{High disaccharide intake associates with atherogenic lipoprotein profile.}}, url = {{http://dx.doi.org/10.1017/S0007114511003783}}, doi = {{10.1017/S0007114511003783}}, volume = {{107}}, year = {{2012}}, }