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2024
Mark Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver
MacKinnon, Alison C. ; Humphries, Duncan C. ; Herman, Kimberley ; Roper, James A. ; Holyer, Ian ; Mabbitt, Joseph ; Mills, Ross ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU and Pedersen, Anders , et al. (2024) In European Journal of Pharmacology 985.
- Contribution to journal › Article
Mark Development and Characterization of a High-Affinity Selective Galectin-3 Mouse Tool Compound in Mouse Models of Cancer
Peterson, Kristoffer ^LU ; Nilsson, Ulf J. ^LU ; Gravelle, Lise ; Holyer, Ian ; Jansson, Karl ; Kahl-Knutson, Barbro ^LU ; Leffler, Hakon ^LU ; MacKinnon, Alison C. ; Roper, James A. and Slack, Robert J. , et al. (2024) In Journal of Medicinal Chemistry 67(24). p.21905-21915
- Contribution to journal › Article
Mark Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer
Zetterberg, Fredrik R. ; Peterson, Kristoffer ; Nilsson, Ulf J. ^LU ; Andréasson Dahlgren, Kajsa ; Diehl, Carl ; Hoyler, Ian ; Håkansson, Maria ; Khabut, Areej ^LU ; Kahl-Knutson, Barbro ^LU and Leffler, Hakon ^LU , et al. (2024) In Journal of Medicinal Chemistry 67(11). p.9374-9388
- Contribution to journal › Article
2023
Mark Resistance to anti-PD-1/anti-PD-L1 : galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1
Mabbitt, Joseph ; Holyer, Ian D ; Roper, James A ; Nilsson, Ulf J ^LU ; Zetterberg, Fredrik R ; Vuong, Lynda ; Mackinnon, Alison C ; Pedersen, Anders and Slack, Robert J (2023) In Frontiers in Immunology 14.
- Contribution to journal › Article
Mark Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in healthy participants
Aslanis, Vassilios ; Slack, Robert J. ; MacKinnon, Alison C. ; McClinton, Catherine ; Tantawi, Susan ; Gravelle, Lise ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU ; Brooks, Ashley and Khindri, Sanjeev K. , et al. (2023) In Cancer Chemotherapy and Pharmacology 91(3). p.267-280
- Contribution to journal › Article
2022
Mark Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease
Zetterberg, Fredrik R. ; Mackinnon, Alison ; Brimert, Thomas ; Gravelle, Lise ; Johnsson, Richard E. ; Kahl-Knutson, Barbro ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU ; Pedersen, Anders and Peterson, Kristoffer ^LU , et al. (2022) In Journal of Medicinal Chemistry 65(19). p.12626-12638
- Contribution to journal › Article
Mark Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
Humphries, Duncan C. ; Mills, Ross ; Boz, Cecilia ; McHugh, Brian J. ; Hirani, Nikhil ; Rossi, Adriano G. ; Pedersen, Anders ; Schambye, Hans T. ; Slack, Robert J. and Leffler, Hakon ^LU , et al. (2022) In Frontiers in Pharmacology 13.
- Contribution to journal › Article
2021
Mark Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis
Hirani, Nikhil ; MacKinnon, Alison C. ; Nicol, Lisa ; Ford, Paul ; Schambye, Hans ; Pedersen, Anders ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU ; Sethi, Tariq and Tantawi, Susan , et al. (2021) In European Respiratory Journal 57(5).
- Contribution to journal › Article
2019
Mark An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade
Vuong, Lynda ; Kouverianou, Eleni ; Rooney, Claire M. ; McHugh, Brian J. ; Howie, Sarah E.M. ; Gregory, Christopher D. ; Forbes, Stuart J. ; Henderson, Neil C. ; Zetterberg, Fredrik R. and Nilsson, Ulf J. ^LU , et al. (2019) In Cancer Research 79(7). p.1480-1492
- Contribution to journal › Article
2016
Mark A Selective Galactose–Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model
Rajput, Vishal K. ; Mackinnon, Alison ; Mandal, Santanu ^LU ; Collins, Patrick ; Blanchard, Helen ; Leffler, Hakon ^LU ; Sethi, Tariq ; Schambye, Hans ; Mukhopadhyay, Balaram and Nilsson, Ulf J. ^LU (2016) In Journal of Medicinal Chemistry 59(17). p.8141-8147
- Contribution to journal › Article

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