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2019
Mark A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD⁺-Dependent Enzymes
Yuen, Lik Hang ; Dana, Srikanta ; Liu, Yu ; Bloom, Samuel I ; Thorsell, Ann-Gerd ; Neri, Dario ; Donato, Anthony J ; Kireev, Dmitri ; Schüler, Herwig ^LU and Franzini, Raphael M (2019) In Journal of the American Chemical Society 141(13). p.5169-5181
- Contribution to journal › Article
2018
Mark Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page, Brent D G ; Valerie, Nicholas C K ; Wright, Roni H G ; Wallner, Olov ; Isaksson, Rebecka ; Carter, Megan ; Rudd, Sean G ; Loseva, Olga ; Jemth, Ann-Sofie and Almlöf, Ingrid , et al. (2018) In Nature Communications 9(1).
- Contribution to journal › Article
2017
Mark Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space
Rudling, Axel ; Gustafsson, Robert ; Almlöf, Ingrid ; Homan, Evert ; Scobie, Martin ; Warpman Berglund, Ulrika ; Helleday, Thomas ; Stenmark, Pål ^LU and Carlsson, Jens (2017) In Journal of Medicinal Chemistry 60(19). p.8160-8169
- Contribution to journal › Article
Mark Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
Gustafsson, Robert ; Jemth, Ann-Sofie ; Gustafsson, Nina M S ; Färnegårdh, Katarina ; Loseva, Olga ; Wiita, Elisée ; Bonagas, Nadilly ; Dahllund, Leif ; Llona-Minguez, Sabin and Häggblad, Maria , et al. (2017) In Cancer Research 77(4). p.937-948
- Contribution to journal › Article
Mark Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors
Thorsell, Ann-Gerd ; Ekblad, Torun ; Karlberg, Tobias ^LU ; Löw, Mirjam ; Pinto, Ana Filipa ; Trésaugues, Lionel ; Moche, Martin ; Cohen, Michael S and Schüler, Herwig ^LU (2017) In Journal of Medicinal Chemistry 60(4). p.1262-1271
- Contribution to journal › Article
2015
Mark Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library
Samain, Florent ; Ekblad, Torun ; Mikutis, Gediminas ; Zhong, Nan ; Zimmermann, Mauro ; Nauer, Angela ; Bajic, Davor ; Decurtins, Willy ; Scheuermann, Jörg and Brown, Peter J , et al. (2015) In Journal of Medicinal Chemistry 58(12). p.9-5143
- Contribution to journal › Article
2013
Mark PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3
Lindgren, Anders E G ; Karlberg, Tobias ^LU ; Thorsell, Ann-Gerd ; Hesse, Mareike ; Spjut, Sara ; Ekblad, Torun ; Andersson, C David ; Pinto, Ana Filipa ; Weigelt, Johan and Hottiger, Michael O , et al. (2013) In ACS Chemical Biology 8(8). p.703-1698
- Contribution to journal › Article
2012
Mark Family-wide chemical profiling and structural analysis of PARP and tankyrase inhibitors
Wahlberg, Elisabet ; Karlberg, Tobias ^LU ; Kouznetsova, Ekaterina ; Markova, Natalia ^LU ; Macchiarulo, Antonio ; Thorsell, Ann-Gerd ; Pol, Ewa ; Frostell, Åsa ; Ekblad, Torun and Öncü, Delal , et al. (2012) In Nature Biotechnology 30(3). p.8-283
- Contribution to journal › Article
2009
Mark The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum : importance of active site metal ions in the binding of substrates and inhibitors
Maric, Selma ^LU ; Donnelly, Sheila M ; Robinson, Mark W ; Skinner-Adams, Tina ; Trenholme, Katharine R ; Gardiner, Donald L ; Dalton, John P ; Stack, Colin M and Lowther, Jonathan (2009) In Biochemistry 48(23). p.9-5435
- Contribution to journal › Article
Mark Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3
Lehtiö, Lari ; Jemth, Ann-Sofie ; Collins, Ruairi ; Loseva, Olga ; Johansson, Andreas ; Markova, Natalia ^LU ; Hammarström, Martin ; Flores, Alex ; Holmberg-Schiavone, Lovisa and Weigelt, Johan , et al. (2009) In Journal of Medicinal Chemistry 52(9). p.11-3108
- Contribution to journal › Article