Salam Al-Karadaghi
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- 2022
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Mark
Crystal structure and initial characterization of a novel archaeal-like Holliday junction-resolving enzyme from Thermus thermophilus phage Tth15-6
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- Contribution to journal › Article
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Mark
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold : SAR of the Aryloxyaryl Moiety
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- Contribution to journal › Article
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Mark
Crystal structure of DNA polymerase I from Thermus phage G20c
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- Contribution to journal › Article
- 2021
-
Mark
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold : SAR of the Biphenyl Moiety
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- Contribution to journal › Article
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Mark
Going to extremes - a metagenomic journey into the dark matter of life
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- Contribution to journal › Scientific review
- 2019
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Mark
Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors : Synthesis, biological evaluation and X-ray structural studies
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- Contribution to journal › Article
- 2018
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Mark
Structural modelling of the DNAJB6 oligomeric chaperone shows a peptide-binding cleft lined with conserved S/T-residues at the dimer interface
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- Contribution to journal › Article
- 2017
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Mark
SAXS and stability studies of iron-induced oligomers of bacterial frataxin CyaY
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- Contribution to journal › Article
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Mark
Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds
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- Contribution to journal › Article
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Mark
4-Hydroxy-N -[3,5-bis(trifluoromethyl)phenyl]-1,2,5-thiadiazole-3-carboxamide: A novel inhibitor of the canonical NF-κB cascade
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- Contribution to journal › Article
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Mark
Iron-induced oligomerization of human FXN81-210 and bacterial CyaY frataxin and the effect of iron chelators
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- Contribution to journal › Article
- 2016
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Mark
Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: The Sub-Complex Formed by the Iron Donor, Yfh1, and the Scaffold, Isu1.
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- Contribution to journal › Article
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Mark
Architecture of the human mitochondrial iron-sulfur cluster assembly machinery
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- Contribution to journal › Article
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Mark
The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model
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- Contribution to journal › Article
- 2014
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Mark
Magnesium chelatase: The molecular motor of chlorophyll biosynthesis.
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- Chapter in Book/Report/Conference proceeding › Book chapter
- 2013
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Mark
The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization.
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- Contribution to journal › Article
- 2012
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Mark
Structure of the Cyanobacterial Magnesium Chelatase H Subunit Determined by Single Particle Reconstruction and Small-angle X-ray Scattering
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- Contribution to journal › Article
- 2011
-
Mark
Oligomerization Propensity and Flexibility of Yeast Frataxin Studied by X-ray Crystallography and Small-Angle X-ray Scattering.
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- Contribution to journal › Article
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Mark
Ferrochelatase: the convergence of the porphyrin biosynthesis and iron transport pathways
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- Contribution to journal › Article
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Mark
Resonance Raman spectroscopic examination of ferrochelatase-induced porphyrin distortion
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- Contribution to journal › Article
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Mark
Bacterial ferrochelatase turns human: Tyr13 determines the apparent metal specificity of Bacillus subtilis ferrochelatase.
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- Contribution to journal › Article
- 2010
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Mark
Structure studies of human frataxin and its higher order structures: implication in Friedreich's ataxia
2010) 35th Congress of the Federation-of-European-Biochemical-Societies In The FEBS Journal 277(Suppl. 1). p.259-259(
- Contribution to journal › Published meeting abstract
-
Mark
ATP-induced conformational dynamics in the AAA+ motor unit of magnesium chelatase.
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- Contribution to journal › Article
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Mark
Inhibition of Human DHODH by 4-Hydroxycoumarins, Fenamic Acids, and N-(Alkylcarbonyl)anthranilic Acids Identified by Structure-Guided Fragment Selection
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- Contribution to journal › Article
- 2009
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Mark
The AAA(+) motor complex of subunits CobS and CobT of cobaltochelatase visualized by single particle electron microscopy.
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- Contribution to journal › Article
- 2008
-
Mark
The structures of human dihydroorotate dehydrogenase with and without inhibitor reveal conformational flexibility in the inhibitor and substrate binding sites.
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- Contribution to journal › Article
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Mark
Structural basis of the iron storage function of frataxin from single-particle reconstruction of the iron-loaded oligomer
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- Contribution to journal › Article
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Mark
Substrate-binding model of the chlorophyll biosynthetic magnesium chelatase BchH subunit.
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- Contribution to journal › Article
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Mark
Porphyrin Binding and Distortion and Substrate Specificity in the Ferrochelatase Reaction: The Role of Active Site Residues.
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- Contribution to journal › Article
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Mark
A new cryo-EM single-particle Ab initio reconstruction method visualizes secondary structure elements in an ATP-Fueled AAA+ motor
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- Contribution to journal › Article
- 2007
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Mark
Amino acid residues His183 and Glu264 in Bacillus subtilis ferrochelatase direct and facilitate the insertion of metal ion into protoporphyrin IX
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- Contribution to journal › Article
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Mark
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 3-aminooxy-1-aminopropane
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- Contribution to journal › Article
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Mark
Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO
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- Contribution to journal › Article
- 2006
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Mark
The structures of frataxin oligomers reveal the mechanism for the delivery and detoxification of iron
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- Contribution to journal › Article
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Mark
Characterization of insulin microcrystals using powder diffraction and multivariate data analysis
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- Contribution to journal › Article
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Mark
Chelatases: distort to select?
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- Contribution to journal › Debate/Note/Editorial
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Mark
Transmembrane topology of FRO2, a ferric chelate reductase from Arabidopsis thaliana
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- Contribution to journal › Article
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Mark
ATPase activity associated with the magnesium chelatase H-subunit of the chlorophyll biosynthetic pathway is an artefact
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- Contribution to journal › Article
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Mark
Recessiveness and Dominance in Barley Mutants Deficient in Mg-Chelatase Subunit D, an AAA Protein Involved in Chlorophyll Biosynthesis.
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- Contribution to journal › Article
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Mark
Structural Aspects of Protein Synthesis
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- Contribution to journal › Review (Book/Film/Exhibition/etc.)
- 2005
-
Mark
Metallation of the transition-state inhibitor N-methyl mesoporphyrin by ferrochelatase: Implications for the catalytic reaction mechanism
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- Contribution to journal › Article
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Mark
Cloning, expression, characterisation and three-dimensional structure determination of Caenorhabditis elegans spermidine synthase
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- Contribution to journal › Article
-
Mark
Immunolocalization of the saposin-like insert of plant aspartic proteinases exhibiting saposin C activity. Expression in young flower tissues and in barley seeds
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- Contribution to journal › Article
- 2004
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Mark
EM single particle analysis of the ATP-dependent BchI complex of magnesium chelatase: an AAA+ hexamer
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- Contribution to journal › Article
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Mark
Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins.
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- Contribution to journal › Article
- 2003
-
Mark
Metal binding to Bacillus subtilis ferrochelatase and interaction between metal sites.
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- Contribution to journal › Article
- 2002
-
Mark
Metal Binding to Saccharomyces cerevisiae Ferrochelatase
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- Contribution to journal › Article
-
Mark
In vivo and in vitro studies of Bacillus subtilis ferrochelatase mutants suggest substrate channeling in the heme biosynthesis pathway.
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- Contribution to journal › Article
-
Mark
Occurrence, conformational features and amino acid propensities for the pi-helix.
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- Contribution to journal › Article
- 2001
-
Mark
Interplay Between an AAA Module and an Integrin I Domain May Regulate the Function of Magnesium Chelatase
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- Contribution to journal › Article