The Protective Association of High Plasma Enterolactone with Breast Cancer Is Reasonably Robust in Women with Polymorphisms in the Estrogen Receptor alpha and beta Genes
(2009) In Journal of Nutrition 139(5). p.993-1001- Abstract
- It is plausible that polymorph isms in the estrogen receptor alpha and beta genes (ESR1 and ESR2) may modulate the association between enterolactone and breast cancer. Seven polymorph isms in ESR1 (rs827422, rs1709184, rs2347867, rs3020328, rs72207, rs2982896, and rs2234693) and 5 polymorphisms in ESR2 (rs915057, rs1269056, rs1256033, rs3020450, and rs3020443) were selected. The risk of breast cancer for these polymorphisms was estimated among 542 cases and 1076 matched controls from the population-based Malmo Diet and Cancer cohort. The joint effect of these polymorphisms and enterolactone was estimated among those individuals about whom we had information on enterolactone blood concentration (365 cases and 728 controls). Breast cancer... (More)
- It is plausible that polymorph isms in the estrogen receptor alpha and beta genes (ESR1 and ESR2) may modulate the association between enterolactone and breast cancer. Seven polymorph isms in ESR1 (rs827422, rs1709184, rs2347867, rs3020328, rs72207, rs2982896, and rs2234693) and 5 polymorphisms in ESR2 (rs915057, rs1269056, rs1256033, rs3020450, and rs3020443) were selected. The risk of breast cancer for these polymorphisms was estimated among 542 cases and 1076 matched controls from the population-based Malmo Diet and Cancer cohort. The joint effect of these polymorphisms and enterolactone was estimated among those individuals about whom we had information on enterolactone blood concentration (365 cases and 728 controls). Breast cancer risk was not significantly associated with any of the selected polymorphisms. We found a tendency for an interaction between a polymorphism in intron 3 of ESR1 (rs2347867) and enterolactone concentration (P = 0.07). Breast cancer and enterolactone concentration were not associated among those homozygous for the major allele (A) (P = 0.93), whereas we found an inverse association among carriers of the minor allele (G) (P = 0.007). None of the other polymorphisms seem to modify the association between enterolactone and breast cancer. This study suggests that the protective association of enterolactone is reasonably robust across the investigated genotypes. The suggested interaction between enterolactone concentration and rs2347867 needs to be confirmed in larger samples. J. Nutr. 139: 993-1001, 2009. (Less)
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https://lup.lub.lu.se/record/1399481
- author
- Sonestedt, Emily LU ; Ivarsson, Malin I. L. ; Harlid, Sophia LU ; Ericson, Ulrika LU ; Gullberg, Bo LU ; Carlson, Joyce LU ; Olsson, Hakan LU ; Adlercreutz, Herman and Wirfält, Elisabet LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Nutrition
- volume
- 139
- issue
- 5
- pages
- 993 - 1001
- publisher
- Oxford University Press
- external identifiers
-
- wos:000265424500027
- scopus:65349156844
- pmid:19321582
- ISSN
- 1541-6100
- DOI
- 10.3945/jn.108.101691
- language
- English
- LU publication?
- yes
- id
- 8c46b44c-fc49-43d4-b903-3326bd8caccb (old id 1399481)
- date added to LUP
- 2016-04-01 11:49:18
- date last changed
- 2022-04-05 05:33:52
@article{8c46b44c-fc49-43d4-b903-3326bd8caccb, abstract = {{It is plausible that polymorph isms in the estrogen receptor alpha and beta genes (ESR1 and ESR2) may modulate the association between enterolactone and breast cancer. Seven polymorph isms in ESR1 (rs827422, rs1709184, rs2347867, rs3020328, rs72207, rs2982896, and rs2234693) and 5 polymorphisms in ESR2 (rs915057, rs1269056, rs1256033, rs3020450, and rs3020443) were selected. The risk of breast cancer for these polymorphisms was estimated among 542 cases and 1076 matched controls from the population-based Malmo Diet and Cancer cohort. The joint effect of these polymorphisms and enterolactone was estimated among those individuals about whom we had information on enterolactone blood concentration (365 cases and 728 controls). Breast cancer risk was not significantly associated with any of the selected polymorphisms. We found a tendency for an interaction between a polymorphism in intron 3 of ESR1 (rs2347867) and enterolactone concentration (P = 0.07). Breast cancer and enterolactone concentration were not associated among those homozygous for the major allele (A) (P = 0.93), whereas we found an inverse association among carriers of the minor allele (G) (P = 0.007). None of the other polymorphisms seem to modify the association between enterolactone and breast cancer. This study suggests that the protective association of enterolactone is reasonably robust across the investigated genotypes. The suggested interaction between enterolactone concentration and rs2347867 needs to be confirmed in larger samples. J. Nutr. 139: 993-1001, 2009.}}, author = {{Sonestedt, Emily and Ivarsson, Malin I. L. and Harlid, Sophia and Ericson, Ulrika and Gullberg, Bo and Carlson, Joyce and Olsson, Hakan and Adlercreutz, Herman and Wirfält, Elisabet}}, issn = {{1541-6100}}, language = {{eng}}, number = {{5}}, pages = {{993--1001}}, publisher = {{Oxford University Press}}, series = {{Journal of Nutrition}}, title = {{The Protective Association of High Plasma Enterolactone with Breast Cancer Is Reasonably Robust in Women with Polymorphisms in the Estrogen Receptor alpha and beta Genes}}, url = {{http://dx.doi.org/10.3945/jn.108.101691}}, doi = {{10.3945/jn.108.101691}}, volume = {{139}}, year = {{2009}}, }