Reduced neurogenesis in the rat hippocampus following high fructose consumption.
(2011) In Regulatory Peptides 167. p.26-30- Abstract
- In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study add to the list of harmful effects associated with... (More)
- In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study add to the list of harmful effects associated with prolonged and excessive consumption of sugary beverages and soft drinks. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1756982
- author
- Van der Borght, Karin ; Köhnke, Rickard LU ; Göransson, Nathanael ; Deierborg, Tomas LU ; Brundin, Patrik LU ; Erlanson-Albertsson, Charlotte LU and Lindqvist, Andreas LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Regulatory Peptides
- volume
- 167
- pages
- 26 - 30
- publisher
- Elsevier
- external identifiers
-
- wos:000288774900006
- pmid:21115071
- scopus:79951671434
- ISSN
- 1873-1686
- DOI
- 10.1016/j.regpep.2010.11.002
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Apetite Regulation (013212030)
- id
- 8cc76f3a-3d55-4dcc-87b9-16167c7536c0 (old id 1756982)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21115071?dopt=Abstract
- date added to LUP
- 2016-04-04 07:58:57
- date last changed
- 2022-05-01 05:47:14
@article{8cc76f3a-3d55-4dcc-87b9-16167c7536c0, abstract = {{In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study add to the list of harmful effects associated with prolonged and excessive consumption of sugary beverages and soft drinks.}}, author = {{Van der Borght, Karin and Köhnke, Rickard and Göransson, Nathanael and Deierborg, Tomas and Brundin, Patrik and Erlanson-Albertsson, Charlotte and Lindqvist, Andreas}}, issn = {{1873-1686}}, language = {{eng}}, pages = {{26--30}}, publisher = {{Elsevier}}, series = {{Regulatory Peptides}}, title = {{Reduced neurogenesis in the rat hippocampus following high fructose consumption.}}, url = {{http://dx.doi.org/10.1016/j.regpep.2010.11.002}}, doi = {{10.1016/j.regpep.2010.11.002}}, volume = {{167}}, year = {{2011}}, }