Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study

Vergnaud, Anne-Claire ; Norat, Teresa ; Mouw, Traci ; Romaguera, Dora ; May, Anne M. ; Bueno-de-Mesquita, H. Bas ; van der Daphne, A. ; Agudo, Antonio ; Wareham, Nicholas and Khaw, Kay-Tee , et al. (2013) In PLoS ONE 8(3).
Abstract
Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial. Methods: 373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and self-reported at follow-up in most centers. The association between weight change after 5 years of follow-up and the iso-energetic replacement of 5% of energy from one macronutrient by 5% of energy from another macronutrient was assessed using multivariate linear mixed-models. The risk of becoming overweight or obese after 5 years was investigated... (More)
Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial. Methods: 373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and self-reported at follow-up in most centers. The association between weight change after 5 years of follow-up and the iso-energetic replacement of 5% of energy from one macronutrient by 5% of energy from another macronutrient was assessed using multivariate linear mixed-models. The risk of becoming overweight or obese after 5 years was investigated using multivariate Poisson regressions stratified according to initial Body Mass Index. Results: A higher proportion of energy from fat at the expense of carbohydrates was not significantly associated with weight change after 5 years. However, a higher proportion of energy from protein at the expense of fat was positively associated with weight gain. A higher proportion of energy from protein at the expense of carbohydrates was also positively associated with weight gain, especially when carbohydrates were rich in fibre. The association between percentage of energy from protein and weight change was slightly stronger in overweight participants, former smokers, participants >= 60 years old, participants underreporting their energy intake and participants with a prudent dietary pattern. Compared to diets with no more than 14% of energy from protein, diets with more than 22% of energy from protein were associated with a 23-24% higher risk of becoming overweight or obese in normal weight and overweight subjects at baseline. Conclusion: Our results show that participants consuming an amount of protein above the protein intake recommended by the American Diabetes Association may experience a higher risk of becoming overweight or obese during adult life. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
8
issue
3
article number
e57300
publisher
Public Library of Science (PLoS)
external identifiers
  • wos:000315637900018
  • scopus:84874606152
  • pmid:23472080
ISSN
1932-6203
DOI
10.1371/journal.pone.0057300
language
English
LU publication?
yes
id
15b28847-a2b1-4da6-be41-122f25aa6d52 (old id 3636517)
date added to LUP
2016-04-01 13:41:11
date last changed
2022-04-21 22:59:16
@article{15b28847-a2b1-4da6-be41-122f25aa6d52,
  abstract     = {{Background: The effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial. Methods: 373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and self-reported at follow-up in most centers. The association between weight change after 5 years of follow-up and the iso-energetic replacement of 5% of energy from one macronutrient by 5% of energy from another macronutrient was assessed using multivariate linear mixed-models. The risk of becoming overweight or obese after 5 years was investigated using multivariate Poisson regressions stratified according to initial Body Mass Index. Results: A higher proportion of energy from fat at the expense of carbohydrates was not significantly associated with weight change after 5 years. However, a higher proportion of energy from protein at the expense of fat was positively associated with weight gain. A higher proportion of energy from protein at the expense of carbohydrates was also positively associated with weight gain, especially when carbohydrates were rich in fibre. The association between percentage of energy from protein and weight change was slightly stronger in overweight participants, former smokers, participants >= 60 years old, participants underreporting their energy intake and participants with a prudent dietary pattern. Compared to diets with no more than 14% of energy from protein, diets with more than 22% of energy from protein were associated with a 23-24% higher risk of becoming overweight or obese in normal weight and overweight subjects at baseline. Conclusion: Our results show that participants consuming an amount of protein above the protein intake recommended by the American Diabetes Association may experience a higher risk of becoming overweight or obese during adult life.}},
  author       = {{Vergnaud, Anne-Claire and Norat, Teresa and Mouw, Traci and Romaguera, Dora and May, Anne M. and Bueno-de-Mesquita, H. Bas and van der Daphne, A. and Agudo, Antonio and Wareham, Nicholas and Khaw, Kay-Tee and Romieu, Isabelle and Freisling, Heinz and Slimani, Nadia and Perquier, Florence and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Palli, Domenico and Berrino, Franco and Mattiello, Amalia and Tumino, Rosario and Ricceri, Fulvio and Rodriguez, Laudina and Molina-Montes, Esther and Amiano, Pilar and Barricarte, Aurelio and Chirlaque, Maria-Dolores and Crowe, Francesca L. and Orfanos, Philippos and Naska, Androniki and Trichopoulou, Antonia and Teucher, Birgit and Kaaks, Rudolf and Boeing, Heiner and Buijsse, Brian and Johansson, Ingeged and Hallmans, Goran and Drake, Isabel and Sonestedt, Emily and Jakobsen, Marianne Uhre and Overvad, Kim and Tjonneland, Anne and Halkjaer, Jytte and Skeie, Guri and Braaten, Tonje and Lund, Eiliv and Riboli, Elio and Peeters, Petra H. M.}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{3}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Macronutrient Composition of the Diet and Prospective Weight Change in Participants of the EPIC-PANACEA Study}},
  url          = {{https://lup.lub.lu.se/search/files/3532119/4015983.pdf}},
  doi          = {{10.1371/journal.pone.0057300}},
  volume       = {{8}},
  year         = {{2013}},
}