Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women.
Garg, Gaurav LU ; Kumar, Jitender LU ; McGuigan, Fiona LU
; Ridderstråle, Martin
LU
; Gerdhem, Paul
LU
; Luthman, Holger
LU
and Åkesson, Kristina
LU
(2014)
In PLoS ONE
9(2).
- Abstract
- Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044). Body mass index... (More)
- Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044). Body mass index (BMI), total body fat and lean mass were strongly positively correlated with QUS and BMD in both cohorts (r(2) = 0.2-0.6). MC4R rs17782313 was associated with QUS in the OPRA cohort and individuals with the minor C-allele had higher values compared to T-allele homozygotes (TT vs. CT vs. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4334884
- author
- Garg, Gaurav
LU
; Kumar, Jitender
LU
; McGuigan, Fiona
LU
; Ridderstråle, Martin
LU
; Gerdhem, Paul
LU
; Luthman, Holger
LU
and Åkesson, Kristina
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 9
- issue
- 2
- article number
- e88565
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- pmid:24516669
- wos:000330830700077
- scopus:84895535167
- pmid:24516669
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0088565
- language
- English
- LU publication?
- yes
- id
- 6c15cb1d-c143-4562-90df-ce8945e09829 (old id 4334884)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24516669?dopt=Abstract
- date added to LUP
- 2016-04-01 13:35:32
- date last changed
- 2023-09-03 01:46:58
@article{6c15cb1d-c143-4562-90df-ce8945e09829,
abstract = {{Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044). Body mass index (BMI), total body fat and lean mass were strongly positively correlated with QUS and BMD in both cohorts (r(2) = 0.2-0.6). MC4R rs17782313 was associated with QUS in the OPRA cohort and individuals with the minor C-allele had higher values compared to T-allele homozygotes (TT vs. CT vs.}},
author = {{Garg, Gaurav and Kumar, Jitender and McGuigan, Fiona and Ridderstråle, Martin and Gerdhem, Paul and Luthman, Holger and Åkesson, Kristina}},
issn = {{1932-6203}},
language = {{eng}},
number = {{2}},
publisher = {{Public Library of Science (PLoS)}},
series = {{PLoS ONE}},
title = {{Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women.}},
url = {{https://lup.lub.lu.se/search/files/3465006/4628824.pdf}},
doi = {{10.1371/journal.pone.0088565}},
volume = {{9}},
year = {{2014}},
}