Dietary Fat Intake and Development of Specific Breast Cancer Subtypes.
(2014) In Journal of the National Cancer Institute 106(5). p.068-068- Abstract
- We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake... (More)
- We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4430440
- author
- Sieri, Sabina
; Chiodini, Paolo
; Agnoli, Claudia
; Pala, Valeria
; Berrino, Franco
; Trichopoulou, Antonia
; Benetou, Vassiliki
; Vasilopoulou, Effie
; Sánchez, María-José
; Chirlaque, Maria-Dolores
; Amiano, Pilar
; Quirós, J Ramón
; Ardanaz, Eva
; Buckland, Genevieve
; Masala, Giovanna
; Panico, Salvatore
; Grioni, Sara
; Sacerdote, Carlotta
; Tumino, Rosario
; Boutron-Ruault, Marie-Christine
; Clavel-Chapelon, Françoise
; Fagherazzi, Guy
; Peeters, Petra H M
; van Gils, Carla H
; Bueno-de-Mesquita, H Bas
; van Kranen, Henk J
; Key, Timothy J
; Travis, Ruth C
; Khaw, Kay Tee
; Wareham, Nicholas J
; Kaaks, Rudolf
; Lukanova, Annekatrin
; Boeing, Heiner
; Schütze, Madlen
; Sonestedt, Emily
LU
; Wirfält, Elisabet
LU
; Sund, Malin
; Andersson, Anne
; Chajes, Veronique
; Rinaldi, Sabina
; Romieu, Isabelle
; Weiderpass, Elisabete
; Skeie, Guri
; Dagrun, Engeset
; Tjønneland, Anne
; Halkjær, Jytte
; Overvard, Kim
; Merritt, Melissa A
; Cox, David
; Riboli, Elio
and Krogh, Vittorio
(Less) - organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the National Cancer Institute
- volume
- 106
- issue
- 5
- pages
- 068 - 068
- publisher
- Oxford University Press
- external identifiers
-
- wos:000341636100013
- pmid:24718872
- scopus:84905196278
- pmid:24718872
- ISSN
- 1460-2105
- DOI
- 10.1093/jnci/dju068
- language
- English
- LU publication?
- yes
- id
- 19c7c17a-6afc-43f2-9ec0-c79658f082ea (old id 4430440)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24718872?dopt=Abstract
- date added to LUP
- 2016-04-01 10:35:23
- date last changed
- 2022-04-20 03:35:25
@article{19c7c17a-6afc-43f2-9ec0-c79658f082ea,
abstract = {{We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.}},
author = {{Sieri, Sabina and Chiodini, Paolo and Agnoli, Claudia and Pala, Valeria and Berrino, Franco and Trichopoulou, Antonia and Benetou, Vassiliki and Vasilopoulou, Effie and Sánchez, María-José and Chirlaque, Maria-Dolores and Amiano, Pilar and Quirós, J Ramón and Ardanaz, Eva and Buckland, Genevieve and Masala, Giovanna and Panico, Salvatore and Grioni, Sara and Sacerdote, Carlotta and Tumino, Rosario and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Françoise and Fagherazzi, Guy and Peeters, Petra H M and van Gils, Carla H and Bueno-de-Mesquita, H Bas and van Kranen, Henk J and Key, Timothy J and Travis, Ruth C and Khaw, Kay Tee and Wareham, Nicholas J and Kaaks, Rudolf and Lukanova, Annekatrin and Boeing, Heiner and Schütze, Madlen and Sonestedt, Emily and Wirfält, Elisabet and Sund, Malin and Andersson, Anne and Chajes, Veronique and Rinaldi, Sabina and Romieu, Isabelle and Weiderpass, Elisabete and Skeie, Guri and Dagrun, Engeset and Tjønneland, Anne and Halkjær, Jytte and Overvard, Kim and Merritt, Melissa A and Cox, David and Riboli, Elio and Krogh, Vittorio}},
issn = {{1460-2105}},
language = {{eng}},
number = {{5}},
pages = {{068--068}},
publisher = {{Oxford University Press}},
series = {{Journal of the National Cancer Institute}},
title = {{Dietary Fat Intake and Development of Specific Breast Cancer Subtypes.}},
url = {{https://lup.lub.lu.se/search/files/1970623/4926532.pdf}},
doi = {{10.1093/jnci/dju068}},
volume = {{106}},
year = {{2014}},
}