In situ assembly of an injectable cardiac stimulator
(2024) In Nature Communications 15.- Abstract
- Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation devices is not feasible. Here, we introduce an injectable cardiac stimulator, a syringe loaded with a nanoparticle solution comprising a conductive polymer and a monomer that, upon injection, forms a conductive structure around the heart for cardiac stimulation. Following treatment, the electrode is cleared from the body, eliminating the need for surgical extraction. The mixture adheres to the beating heart in vivo without disrupting its normal rhythm. The electrofunctionalized injectable cardiac... (More)
- Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation devices is not feasible. Here, we introduce an injectable cardiac stimulator, a syringe loaded with a nanoparticle solution comprising a conductive polymer and a monomer that, upon injection, forms a conductive structure around the heart for cardiac stimulation. Following treatment, the electrode is cleared from the body, eliminating the need for surgical extraction. The mixture adheres to the beating heart in vivo without disrupting its normal rhythm. The electrofunctionalized injectable cardiac stimulator demonstrates a tissue-compatible Young’s modulus of 21 kPa and a high conductivity of 55 S/cm. The injected electrode facilitates electrocardiogram measurements, regulates heartbeat in vivo, and rectifies arrhythmia. Conductive functionality is maintained for five consecutive days, and no toxicity is observed at the organism, organ, or cellular levels. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/46228da3-b6cd-4238-97c6-16d241dd4433
- author
- organization
-
- Chemical Biology and Therapeutics (research group)
- NanoLund: Centre for Nanoscience
- LTH Profile Area: Nanoscience and Semiconductor Technology
- LU Profile Area: Light and Materials
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- LTH Profile Area: Engineering Health
- Pure and Applied Biochemistry
- Thoracic Surgery
- LUCC: Lund University Cancer Centre
- Centre for Analysis and Synthesis
- publishing date
- 2024-08-08
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Communications
- volume
- 15
- article number
- 6774
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85200849913
- ISSN
- 2041-1723
- DOI
- 10.1038/s41467-024-51111-4
- language
- English
- LU publication?
- yes
- id
- 46228da3-b6cd-4238-97c6-16d241dd4433
- date added to LUP
- 2024-08-22 13:47:38
- date last changed
- 2024-08-23 04:01:10
@article{46228da3-b6cd-4238-97c6-16d241dd4433, abstract = {{Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation devices is not feasible. Here, we introduce an injectable cardiac stimulator, a syringe loaded with a nanoparticle solution comprising a conductive polymer and a monomer that, upon injection, forms a conductive structure around the heart for cardiac stimulation. Following treatment, the electrode is cleared from the body, eliminating the need for surgical extraction. The mixture adheres to the beating heart in vivo without disrupting its normal rhythm. The electrofunctionalized injectable cardiac stimulator demonstrates a tissue-compatible Young’s modulus of 21 kPa and a high conductivity of 55 S/cm. The injected electrode facilitates electrocardiogram measurements, regulates heartbeat in vivo, and rectifies arrhythmia. Conductive functionality is maintained for five consecutive days, and no toxicity is observed at the organism, organ, or cellular levels.}}, author = {{Aydemir, Umut and Mousa, Abdelrazek H. and Dicko, Cedric and Strakosas, Xenofon and Shameem, Muhammad Anwar and Hellman, Karin and Yadav, Amit Singh and Ekström, Peter and Hughes, Damien and Ek, Fredrik and Berggren, Magnus and Arner, Anders and Hjort, Martin and Olsson, Roger}}, issn = {{2041-1723}}, language = {{eng}}, month = {{08}}, publisher = {{Nature Publishing Group}}, series = {{Nature Communications}}, title = {{In situ assembly of an injectable cardiac stimulator}}, url = {{http://dx.doi.org/10.1038/s41467-024-51111-4}}, doi = {{10.1038/s41467-024-51111-4}}, volume = {{15}}, year = {{2024}}, }