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In situ assembly of an injectable cardiac stimulator

Aydemir, Umut LU orcid ; Mousa, Abdelrazek H. ; Dicko, Cedric LU orcid ; Strakosas, Xenofon LU ; Shameem, Muhammad Anwar LU ; Hellman, Karin LU ; Yadav, Amit Singh LU ; Ekström, Peter LU ; Hughes, Damien LU and Ek, Fredrik LU , et al. (2024) In Nature Communications 15.
Abstract
Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation devices is not feasible. Here, we introduce an injectable cardiac stimulator, a syringe loaded with a nanoparticle solution comprising a conductive polymer and a monomer that, upon injection, forms a conductive structure around the heart for cardiac stimulation. Following treatment, the electrode is cleared from the body, eliminating the need for surgical extraction. The mixture adheres to the beating heart in vivo without disrupting its normal rhythm. The electrofunctionalized injectable cardiac... (More)
Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation devices is not feasible. Here, we introduce an injectable cardiac stimulator, a syringe loaded with a nanoparticle solution comprising a conductive polymer and a monomer that, upon injection, forms a conductive structure around the heart for cardiac stimulation. Following treatment, the electrode is cleared from the body, eliminating the need for surgical extraction. The mixture adheres to the beating heart in vivo without disrupting its normal rhythm. The electrofunctionalized injectable cardiac stimulator demonstrates a tissue-compatible Young’s modulus of 21 kPa and a high conductivity of 55 S/cm. The injected electrode facilitates electrocardiogram measurements, regulates heartbeat in vivo, and rectifies arrhythmia. Conductive functionality is maintained for five consecutive days, and no toxicity is observed at the organism, organ, or cellular levels. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
15
article number
6774
publisher
Nature Publishing Group
external identifiers
  • scopus:85200849913
ISSN
2041-1723
DOI
10.1038/s41467-024-51111-4
language
English
LU publication?
yes
id
46228da3-b6cd-4238-97c6-16d241dd4433
date added to LUP
2024-08-22 13:47:38
date last changed
2024-08-23 04:01:10
@article{46228da3-b6cd-4238-97c6-16d241dd4433,
  abstract     = {{Without intervention, cardiac arrhythmias pose a risk of fatality. However, timely intervention can be challenging in environments where transporting a large, heavy defibrillator is impractical, or emergency surgery to implant cardiac stimulation devices is not feasible. Here, we introduce an injectable cardiac stimulator, a syringe loaded with a nanoparticle solution comprising a conductive polymer and a monomer that, upon injection, forms a conductive structure around the heart for cardiac stimulation. Following treatment, the electrode is cleared from the body, eliminating the need for surgical extraction. The mixture adheres to the beating heart in vivo without disrupting its normal rhythm. The electrofunctionalized injectable cardiac stimulator demonstrates a tissue-compatible Young’s modulus of 21 kPa and a high conductivity of 55 S/cm. The injected electrode facilitates electrocardiogram measurements, regulates heartbeat in vivo, and rectifies arrhythmia. Conductive functionality is maintained for five consecutive days, and no toxicity is observed at the organism, organ, or cellular levels.}},
  author       = {{Aydemir, Umut and Mousa, Abdelrazek H. and Dicko, Cedric and Strakosas, Xenofon and Shameem, Muhammad Anwar and Hellman, Karin and Yadav, Amit Singh and Ekström, Peter and Hughes, Damien and Ek, Fredrik and Berggren, Magnus and Arner, Anders and Hjort, Martin and Olsson, Roger}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{In situ assembly of an injectable cardiac stimulator}},
  url          = {{http://dx.doi.org/10.1038/s41467-024-51111-4}},
  doi          = {{10.1038/s41467-024-51111-4}},
  volume       = {{15}},
  year         = {{2024}},
}