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Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress

Chen, Yihong LU ; Shen, Junyan LU ; Hultgårdh Nilsson, Anna LU ; Goncalves, Isabel LU orcid ; Edsfeldt, Andreas LU ; Engström, Gunnar LU ; Zaigham, Suneela LU ; Melander, Olle LU orcid ; Orho-Melander, Marju LU and Rauch, Uwe LU , et al. (2022) In JACC: Basic to Translational Science 7(8). p.747-762
Abstract
Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
JACC: Basic to Translational Science
volume
7
issue
8
pages
747 - 762
publisher
Elsevier
external identifiers
  • scopus:85135959628
  • pmid:36061342
ISSN
2452-302X
DOI
10.1016/j.jacbts.2022.03.013
language
English
LU publication?
yes
id
ac7fcda9-0641-4a06-bc3b-e974d3e656aa
date added to LUP
2022-08-09 13:57:59
date last changed
2024-01-18 13:14:11
@article{ac7fcda9-0641-4a06-bc3b-e974d3e656aa,
  abstract     = {{Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.}},
  author       = {{Chen, Yihong and Shen, Junyan and Hultgårdh Nilsson, Anna and Goncalves, Isabel and Edsfeldt, Andreas and Engström, Gunnar and Zaigham, Suneela and Melander, Olle and Orho-Melander, Marju and Rauch, Uwe and Venuraju, Shreenidhi M. and Lahiri, Avijit and Liang, Chun and Jan, Nilsson}},
  issn         = {{2452-302X}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{747--762}},
  publisher    = {{Elsevier}},
  series       = {{JACC: Basic to Translational Science}},
  title        = {{Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress}},
  url          = {{http://dx.doi.org/10.1016/j.jacbts.2022.03.013}},
  doi          = {{10.1016/j.jacbts.2022.03.013}},
  volume       = {{7}},
  year         = {{2022}},
}