Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress
(2022) In JACC: Basic to Translational Science 7(8). p.747-762- Abstract
- Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ac7fcda9-0641-4a06-bc3b-e974d3e656aa
- author
- organization
-
- Vessel Wall Biology (research group)
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Translational Studies (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- WCMM-Wallenberg Centre for Molecular Medicine
- Cardiovascular Research - Epidemiology (research group)
- MultiPark: Multidisciplinary research focused on Parkinson´s disease
- Cardiovascular Research - Hypertension (research group)
- Diabetes - Cardiovascular Disease (research group)
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- JACC: Basic to Translational Science
- volume
- 7
- issue
- 8
- pages
- 747 - 762
- publisher
- Elsevier
- external identifiers
-
- scopus:85135959628
- pmid:36061342
- ISSN
- 2452-302X
- DOI
- 10.1016/j.jacbts.2022.03.013
- language
- English
- LU publication?
- yes
- id
- ac7fcda9-0641-4a06-bc3b-e974d3e656aa
- date added to LUP
- 2022-08-09 13:57:59
- date last changed
- 2024-01-18 13:14:11
@article{ac7fcda9-0641-4a06-bc3b-e974d3e656aa, abstract = {{Hepatocyte growth factor (HGF) is released by stressed human vascular cells and promotes vascular cell repair responses in both autocrine and paracrine ways. Subjects with a low capacity to express HGF in response to systemic stress have an increased cardiovascular risk. Human atherosclerotic plaques with a low content of HGF have a more unstable phenotype. The present study shows that subjects with a low ability to express HGF in response to metabolic stress have an increased risk to suffer myocardial infarction and stroke.}}, author = {{Chen, Yihong and Shen, Junyan and Hultgårdh Nilsson, Anna and Goncalves, Isabel and Edsfeldt, Andreas and Engström, Gunnar and Zaigham, Suneela and Melander, Olle and Orho-Melander, Marju and Rauch, Uwe and Venuraju, Shreenidhi M. and Lahiri, Avijit and Liang, Chun and Jan, Nilsson}}, issn = {{2452-302X}}, language = {{eng}}, number = {{8}}, pages = {{747--762}}, publisher = {{Elsevier}}, series = {{JACC: Basic to Translational Science}}, title = {{Circulating Hepatocyte Growth Factor Reflects Activation of Vascular Repair in Response to Stress}}, url = {{http://dx.doi.org/10.1016/j.jacbts.2022.03.013}}, doi = {{10.1016/j.jacbts.2022.03.013}}, volume = {{7}}, year = {{2022}}, }