Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort
(2024) In PLoS ONE 19(12 December).- Abstract
Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. EPIC questionnaire data were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority to assess long-term dietary mycotoxin exposure (expressed as μg/kg body weight/day) and then relate them to the risk of hepatocellular carcinoma (HCC) (n = 255) and biliary... (More)
Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. EPIC questionnaire data were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority to assess long-term dietary mycotoxin exposure (expressed as μg/kg body weight/day) and then relate them to the risk of hepatocellular carcinoma (HCC) (n = 255) and biliary tract cancers (n = 273). Analyses were conducted using multivariable Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (95% CI). Key food groups contributing to mycotoxin exposure were cereals and cereal-based products, vegetables, non-alcoholic beverages (including fruit juices) and fruits. Estimated intake of deoxynivalenol (DON) and its derivatives was positively associated with HCC risk (HRT3vsT1: 1.90, 95% CI: 1.18–3.05, p-trend <0.01). No statistically significant associations were found for the other mycotoxins. Further research to confirm our observations and investigate potential underlying mechanisms of these compounds is warranted. These data may provide evidence of HCC risks associated with higher dietary intake levels of DON, which has not yet been classified as a human carcinogen.
(Less)
- author
- organization
- publishing date
- 2024-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 19
- issue
- 12 December
- article number
- e0315561
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- scopus:85212677562
- pmid:39680546
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0315561
- language
- English
- LU publication?
- yes
- id
- ba85d0bd-f659-4a3d-99dd-8ef8be0e79e3
- date added to LUP
- 2025-01-17 11:25:51
- date last changed
- 2025-08-02 17:49:55
@article{ba85d0bd-f659-4a3d-99dd-8ef8be0e79e3, abstract = {{<p>Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. EPIC questionnaire data were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority to assess long-term dietary mycotoxin exposure (expressed as μg/kg body weight/day) and then relate them to the risk of hepatocellular carcinoma (HCC) (n = 255) and biliary tract cancers (n = 273). Analyses were conducted using multivariable Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (95% CI). Key food groups contributing to mycotoxin exposure were cereals and cereal-based products, vegetables, non-alcoholic beverages (including fruit juices) and fruits. Estimated intake of deoxynivalenol (DON) and its derivatives was positively associated with HCC risk (HR<sub>T3vsT1</sub>: 1.90, 95% CI: 1.18–3.05, p-trend <0.01). No statistically significant associations were found for the other mycotoxins. Further research to confirm our observations and investigate potential underlying mechanisms of these compounds is warranted. These data may provide evidence of HCC risks associated with higher dietary intake levels of DON, which has not yet been classified as a human carcinogen.</p>}}, author = {{Huybrechts, Inge and Jacobs, Inarie and Biessy, Carine and Aglago, Elom K. and Jenab, Mazda and Claeys, Liesel and Zavadil, Jiri and Casagrande, Corinne and Nicolas, Genevieve and Scelo, Ghislaine and Altieri, Andrea and Fervers, Beatrice and Oswald, Isabelle P. and Vignard, Julien and Chimera, Bernadette and de Magistris, Maria Santucci and Masala, Giovanna and Palli, Domenico and Padroni, Lisa and Castilla, Jesús and Jiménez-Zabala, Ana and Frenoy, Pauline and Mancini, Francesca Romana and Ren, Xuan and Sonestedt, Emily and Vineis, Paolo and Heath, Alicia and Werner, Mårten and Molina-Montes, Esther and Dahm, Christina C. and Langmann, Fie and Huerta, José María and Brustad, Magritt and Skeie, Guri and Schulze, Matthias B. and Agudo, Antonio and Sieri, Sabina and Korenjak, Michael and Gunter, Marc J. and De Saeger, Sarah and De Boevre, Marthe}}, issn = {{1932-6203}}, language = {{eng}}, number = {{12 December}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort}}, url = {{http://dx.doi.org/10.1371/journal.pone.0315561}}, doi = {{10.1371/journal.pone.0315561}}, volume = {{19}}, year = {{2024}}, }