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Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort

Huybrechts, Inge ; Jacobs, Inarie ; Biessy, Carine ; Aglago, Elom K. ; Jenab, Mazda ; Claeys, Liesel ; Zavadil, Jiri ; Casagrande, Corinne ; Nicolas, Genevieve and Scelo, Ghislaine , et al. (2024) In PLoS ONE 19(12 December).
Abstract

Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. EPIC questionnaire data were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority to assess long-term dietary mycotoxin exposure (expressed as μg/kg body weight/day) and then relate them to the risk of hepatocellular carcinoma (HCC) (n = 255) and biliary... (More)

Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. EPIC questionnaire data were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority to assess long-term dietary mycotoxin exposure (expressed as μg/kg body weight/day) and then relate them to the risk of hepatocellular carcinoma (HCC) (n = 255) and biliary tract cancers (n = 273). Analyses were conducted using multivariable Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (95% CI). Key food groups contributing to mycotoxin exposure were cereals and cereal-based products, vegetables, non-alcoholic beverages (including fruit juices) and fruits. Estimated intake of deoxynivalenol (DON) and its derivatives was positively associated with HCC risk (HRT3vsT1: 1.90, 95% CI: 1.18–3.05, p-trend <0.01). No statistically significant associations were found for the other mycotoxins. Further research to confirm our observations and investigate potential underlying mechanisms of these compounds is warranted. These data may provide evidence of HCC risks associated with higher dietary intake levels of DON, which has not yet been classified as a human carcinogen.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
19
issue
12 December
article number
e0315561
publisher
Public Library of Science (PLoS)
external identifiers
  • scopus:85212677562
  • pmid:39680546
ISSN
1932-6203
DOI
10.1371/journal.pone.0315561
language
English
LU publication?
yes
id
ba85d0bd-f659-4a3d-99dd-8ef8be0e79e3
date added to LUP
2025-01-17 11:25:51
date last changed
2025-08-16 05:29:22
@article{ba85d0bd-f659-4a3d-99dd-8ef8be0e79e3,
  abstract     = {{<p>Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and hepatobiliary cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. EPIC questionnaire data were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority to assess long-term dietary mycotoxin exposure (expressed as μg/kg body weight/day) and then relate them to the risk of hepatocellular carcinoma (HCC) (n = 255) and biliary tract cancers (n = 273). Analyses were conducted using multivariable Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (95% CI). Key food groups contributing to mycotoxin exposure were cereals and cereal-based products, vegetables, non-alcoholic beverages (including fruit juices) and fruits. Estimated intake of deoxynivalenol (DON) and its derivatives was positively associated with HCC risk (HR<sub>T3vsT1</sub>: 1.90, 95% CI: 1.18–3.05, p-trend &lt;0.01). No statistically significant associations were found for the other mycotoxins. Further research to confirm our observations and investigate potential underlying mechanisms of these compounds is warranted. These data may provide evidence of HCC risks associated with higher dietary intake levels of DON, which has not yet been classified as a human carcinogen.</p>}},
  author       = {{Huybrechts, Inge and Jacobs, Inarie and Biessy, Carine and Aglago, Elom K. and Jenab, Mazda and Claeys, Liesel and Zavadil, Jiri and Casagrande, Corinne and Nicolas, Genevieve and Scelo, Ghislaine and Altieri, Andrea and Fervers, Beatrice and Oswald, Isabelle P. and Vignard, Julien and Chimera, Bernadette and de Magistris, Maria Santucci and Masala, Giovanna and Palli, Domenico and Padroni, Lisa and Castilla, Jesús and Jiménez-Zabala, Ana and Frenoy, Pauline and Mancini, Francesca Romana and Ren, Xuan and Sonestedt, Emily and Vineis, Paolo and Heath, Alicia and Werner, Mårten and Molina-Montes, Esther and Dahm, Christina C. and Langmann, Fie and Huerta, José María and Brustad, Magritt and Skeie, Guri and Schulze, Matthias B. and Agudo, Antonio and Sieri, Sabina and Korenjak, Michael and Gunter, Marc J. and De Saeger, Sarah and De Boevre, Marthe}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  number       = {{12 December}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0315561}},
  doi          = {{10.1371/journal.pone.0315561}},
  volume       = {{19}},
  year         = {{2024}},
}