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Clinical staging in Swedish primary care using the Amsterdam Instrumental Activities of Daily Living Questionnaire

Fawad, Ayesha LU orcid ; van der Landen, Sophie M ; Tideman, Pontus LU ; van der Putten-Toorenburg, Angela ; Butterbrod, Elke ; Smith, Ruben LU ; van Westen, Danielle LU orcid ; Calling, Susanna LU ; Midlöv, Patrik LU orcid and Mattsson-Carlgren, Niklas LU orcid , et al. (2026) In Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 18.
Abstract

INTRODUCTION: We assessed the accuracy of the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) for clinical staging in Swedish primary care.

METHODS: Participants from the Swedish BioFINDER Primary Care study were included. Discriminative performance of the A-IADL-Q was evaluated using receiver operating curves. Multinomial and linear regression models assessed associations among A-IADL-Q scores, clinical stage, demographics, cognition, and comorbidities.

RESULTS: Among 623 patients, 148 (23.8%) had subjective cognitive decline (SCD), 274 (43.9%) mild cognitive impairment (MCI), and 201 (32.3%) dementia with a mean (standard deviation) age of 76.7 (7.3). The area under the curve (95% confidence... (More)

INTRODUCTION: We assessed the accuracy of the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) for clinical staging in Swedish primary care.

METHODS: Participants from the Swedish BioFINDER Primary Care study were included. Discriminative performance of the A-IADL-Q was evaluated using receiver operating curves. Multinomial and linear regression models assessed associations among A-IADL-Q scores, clinical stage, demographics, cognition, and comorbidities.

RESULTS: Among 623 patients, 148 (23.8%) had subjective cognitive decline (SCD), 274 (43.9%) mild cognitive impairment (MCI), and 201 (32.3%) dementia with a mean (standard deviation) age of 76.7 (7.3). The area under the curve (95% confidence interval) for discriminating between SCD versus MCI/dementia was 0.89 (0.86-0.91) and for SCD/MCI versus dementia 0.89 (0.87-0.92). Age (
β = -0.25), Mini-Mental State Examination (
β = 0.91) and Montreal Cognitive Assessment (
β = 0.57), but no other demographics and comorbidities, were associated with the A-IADL-Q.

DISCUSSION: The A-IADL-Q may help primary care physicians determine clinical stage and shows promise for use to adequately refer patients to secondary or tertiary care.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
volume
18
article number
e70344
publisher
Elsevier
external identifiers
  • scopus:105036651271
  • pmid:42040886
ISSN
2352-8729
DOI
10.1002/dad2.70344
language
English
LU publication?
yes
additional info
© 2026 The Author(s). Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
id
e3c061b7-39e6-4676-bc7a-670335327e44
date added to LUP
2026-05-17 14:21:16
date last changed
2026-05-19 03:06:50
@article{e3c061b7-39e6-4676-bc7a-670335327e44,
  abstract     = {{<p>INTRODUCTION: We assessed the accuracy of the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) for clinical staging in Swedish primary care.</p><p>METHODS: Participants from the Swedish BioFINDER Primary Care study were included. Discriminative performance of the A-IADL-Q was evaluated using receiver operating curves. Multinomial and linear regression models assessed associations among A-IADL-Q scores, clinical stage, demographics, cognition, and comorbidities.</p><p>RESULTS: Among 623 patients, 148 (23.8%) had subjective cognitive decline (SCD), 274 (43.9%) mild cognitive impairment (MCI), and 201 (32.3%) dementia with a mean (standard deviation) age of 76.7 (7.3). The area under the curve (95% confidence interval) for discriminating between SCD versus MCI/dementia was 0.89 (0.86-0.91) and for SCD/MCI versus dementia 0.89 (0.87-0.92). Age (<br>
 β = -0.25), Mini-Mental State Examination (<br>
 β = 0.91) and Montreal Cognitive Assessment (<br>
 β = 0.57), but no other demographics and comorbidities, were associated with the A-IADL-Q.<br>
 </p><p>DISCUSSION: The A-IADL-Q may help primary care physicians determine clinical stage and shows promise for use to adequately refer patients to secondary or tertiary care.</p>}},
  author       = {{Fawad, Ayesha and van der Landen, Sophie M and Tideman, Pontus and van der Putten-Toorenburg, Angela and Butterbrod, Elke and Smith, Ruben and van Westen, Danielle and Calling, Susanna and Midlöv, Patrik and Mattsson-Carlgren, Niklas and Borgström Bolmsjö, Beata and Stomrud, Erik and Nilsson, Maria H and Hansson, Oskar and Sikkes, Sietske A M and Palmqvist, Sebastian}},
  issn         = {{2352-8729}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring}},
  title        = {{Clinical staging in Swedish primary care using the Amsterdam Instrumental Activities of Daily Living Questionnaire}},
  url          = {{http://dx.doi.org/10.1002/dad2.70344}},
  doi          = {{10.1002/dad2.70344}},
  volume       = {{18}},
  year         = {{2026}},
}