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A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut

Vergani, Stefano LU ; Muleta, Konjit Getachew LU ; Da Silva, Clément LU ; Doyle, Alexander LU ; Kristiansen, Trine Ahn LU ; Sodini, Selene LU ; Krausse, Niklas LU ; Montano, Giorgia LU ; Kotarsky, Knut LU and Nakawesi, Joy LU , et al. (2022) In Immunity 55(10). p.6-1842
Abstract

The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unperturbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addition to B-1a cells, early-life time-stamped B cells included clonally interrelated IgA plasma cells in the gut and bone marrow. These were actively maintained by B cell memory within gut chronic germinal centers and contained commensal microbiota reactivity. Neonatal rotavirus infection recruited recurrent IgA clones that were distinct from... (More)

The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unperturbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addition to B-1a cells, early-life time-stamped B cells included clonally interrelated IgA plasma cells in the gut and bone marrow. These were actively maintained by B cell memory within gut chronic germinal centers and contained commensal microbiota reactivity. Neonatal rotavirus infection recruited recurrent IgA clones that were distinct from those arising by infection with the same antigen in adults. Finally, gut IgA plasma cells arose from the same hematopoietic progenitors as B-1a cells during ontogeny. Thus, a complex layer of neonatally imprinted B cells confer unique antibody responses later in life.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
B cell memory, B-1 cells, early-life exposure, early-life-origin B cells, gut B cells, IgA, plasma cells, rotavirus, time-stamping, window of opportunity
in
Immunity
volume
55
issue
10
pages
6 - 1842
publisher
Cell Press
external identifiers
  • scopus:85139337509
  • pmid:36115337
ISSN
1074-7613
DOI
10.1016/j.immuni.2022.08.018
language
English
LU publication?
yes
id
f3f78c0e-e1bf-499a-856a-e5f3ea65da3c
date added to LUP
2022-11-18 16:10:30
date last changed
2024-12-28 13:21:24
@article{f3f78c0e-e1bf-499a-856a-e5f3ea65da3c,
  abstract     = {{<p>The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unperturbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addition to B-1a cells, early-life time-stamped B cells included clonally interrelated IgA plasma cells in the gut and bone marrow. These were actively maintained by B cell memory within gut chronic germinal centers and contained commensal microbiota reactivity. Neonatal rotavirus infection recruited recurrent IgA clones that were distinct from those arising by infection with the same antigen in adults. Finally, gut IgA plasma cells arose from the same hematopoietic progenitors as B-1a cells during ontogeny. Thus, a complex layer of neonatally imprinted B cells confer unique antibody responses later in life.</p>}},
  author       = {{Vergani, Stefano and Muleta, Konjit Getachew and Da Silva, Clément and Doyle, Alexander and Kristiansen, Trine Ahn and Sodini, Selene and Krausse, Niklas and Montano, Giorgia and Kotarsky, Knut and Nakawesi, Joy and Åkerstrand, Hugo and Vanhee, Stijn and Gupta, Sneh Lata and Bryder, David and Agace, William Winston and Lahl, Katharina and Yuan, Joan}},
  issn         = {{1074-7613}},
  keywords     = {{B cell memory; B-1 cells; early-life exposure; early-life-origin B cells; gut B cells; IgA; plasma cells; rotavirus; time-stamping; window of opportunity}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{6--1842}},
  publisher    = {{Cell Press}},
  series       = {{Immunity}},
  title        = {{A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut}},
  url          = {{http://dx.doi.org/10.1016/j.immuni.2022.08.018}},
  doi          = {{10.1016/j.immuni.2022.08.018}},
  volume       = {{55}},
  year         = {{2022}},
}