Hematopoiesis and Gene Therapy
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- 2017
- The stem cell regulator PEDF is dispensable for maintenance and function of hematopoietic stem cells
- Development of novel therapies for Diamond-Blackfan Anemia
- 2015
- Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia.
- Lentiviral gene therapy using cellular promoters cures type 1 Gaucher disease in mice.
- 2014
- Dppa5 improves hematopoietic stem cell activity by reducing endoplasmic reticulum stress.
- 2012
- Human hematopoietic stem/progenitor cells overexpressing Smad4 exhibit impaired reconstitution potential in vivo.
- Dietary L-leucine improves the anemia in a mouse model for Diamond-Blackfan anemia.
- 2011
- SMAD4 binds HOXA9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by HOXA9 and leukemia transformation.
- Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.
- Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78.