Hakon Leffler
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- 2021
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Mark
Entropy–Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C
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- Contribution to journal › Article
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Mark
Selective Galectin-8N Ligands : The Design and Synthesis of Phthalazinone-d-Galactals
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- Contribution to journal › Article
- 2020
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Mark
Epimers Switch Galectin-9 Domain Selectivity : 3 N-Aryl Galactosides Bind the C-Terminal and Gulosides Bind the N-Terminal
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- Contribution to journal › Article
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Mark
In Vivo Veritas : 18F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors
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- Contribution to journal › Article
- 2019
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Mark
Substituted polyfluoroaryl interactions with an arginine side chain in galectin-3 are governed by steric-, desolvation and electronic conjugation effects
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- Contribution to journal › Article
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Mark
An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade
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- Contribution to journal › Article
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Mark
Extracellular and intracellular small-molecule galectin-3 inhibitors
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- Contribution to journal › Article
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Mark
Human trophoblast requires galectin-3 for cell migration and invasion
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- Contribution to journal › Article
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Mark
Interplay between Conformational Entropy and Solvation Entropy in Protein-Ligand Binding
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- Contribution to journal › Article
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Mark
Letter by Leffler Regarding Article, "Modified Citrus Pectin Prevents Blood-Brain Barrier Disruption in Mouse Subarachnoid Hemorrhage by Inhibiting Galectin-3"
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- Contribution to journal › Letter
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Mark
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
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- Contribution to journal › Article
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Mark
C1-Galactopyranosyl Heterocycle Structure Guides Selectivity : Triazoles Prefer Galectin-1 and Oxazoles Prefer Galectin-3
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- Contribution to journal › Article
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Mark
3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-Sites for High-Affinity and High-Selectivity Inhibition of Galectin-3
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- Contribution to journal › Article
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Mark
Structure and Energetics of Ligand–Fluorine Interactions with Galectin-3 Backbone and Side-Chain Amides : Insight into Solvation Effects and Multipolar Interactions
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- Contribution to journal › Article
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Mark
A galactoside-binding protein tricked into binding unnatural pyranose derivatives : 3-deoxy-3-methyl-gulosides selectively inhibit galectin-1
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- Contribution to journal › Article