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Dyskinesias following neural transplantation in Parkinson's disease.

Hagell, Peter LU ; Piccini, Paola; Björklund, Anders LU ; Brundin, Patrik LU ; Rehncrona, Stig LU ; Widner, Håkan LU ; Crabb, Lesley; Pavese, Nicola; Oertel, Wolfgang H and Quinn, Niall, et al. (2002) In Nature Neuroscience 5(7). p.627-628
Abstract
Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted... (More)
Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons. (Less)
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Parkinson Disease : therapy, Parkinson Disease : radionuclide imaging, Neurons : transplantation, Middle Age, Mesencephalon : transplantation, Mesencephalon : embryology, Mesencephalon : cytology, Hyperkinesis : etiology, Hyperkinesis : diagnosis, Human, Dystonia : etiology, Dystonia : diagnosis, Dyskinesias : etiology, Dyskinesias : diagnosis, Disease Progression, Cultured, Cells, Brain Tissue Transplantation : adverse effects, Cell Division : physiology, Postoperative Complications : diagnosis, Postoperative Complications : etiology, Putamen : physiopathology, Putamen : radionuclide imaging, Retrospective Studies, Support, Non-U.S. Gov't, Time Factors
in
Nature Neuroscience
volume
5
issue
7
pages
627 - 628
publisher
Nature Publishing Group
external identifiers
  • wos:000176414300009
  • pmid:12042822
  • scopus:0036307190
ISSN
1546-1726
DOI
10.1038/nn863
language
English
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yes
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2ec5f747-3783-4a4a-9f82-78c3e8279974 (old id 109001)
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12042822&dopt=Abstract
date added to LUP
2007-07-06 09:30:00
date last changed
2017-11-19 04:14:06
@article{2ec5f747-3783-4a4a-9f82-78c3e8279974,
  abstract     = {Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic tissue. Here we retrospectively analyzed 14 patients who were followed for up to 11 years after grafting, and found that dyskinesias (abnormal involuntary movements and postures) increased during postoperative off phases, but were generally of mild to moderate severity. Dyskinesia severity was not related to the magnitude of graft-derived dopaminergic re-innervation, as judged by (18)F-labeled 6-L-fluorodopa (FD) positron emission tomography (PET), indicating that off-phase dyskinesias probably did not result from excessive growth of grafted dopaminergic neurons.},
  author       = {Hagell, Peter and Piccini, Paola and Björklund, Anders and Brundin, Patrik and Rehncrona, Stig and Widner, Håkan and Crabb, Lesley and Pavese, Nicola and Oertel, Wolfgang H and Quinn, Niall and Brooks, David J and Lindvall, Olle},
  issn         = {1546-1726},
  keyword      = {Parkinson Disease : therapy,Parkinson Disease : radionuclide imaging,Neurons : transplantation,Middle Age,Mesencephalon : transplantation,Mesencephalon : embryology,Mesencephalon : cytology,Hyperkinesis : etiology,Hyperkinesis : diagnosis,Human,Dystonia : etiology,Dystonia : diagnosis,Dyskinesias : etiology,Dyskinesias : diagnosis,Disease Progression,Cultured,Cells,Brain Tissue Transplantation : adverse effects,Cell Division : physiology,Postoperative Complications : diagnosis,Postoperative Complications : etiology,Putamen : physiopathology,Putamen : radionuclide imaging,Retrospective Studies,Support,Non-U.S. Gov't,Time Factors},
  language     = {eng},
  number       = {7},
  pages        = {627--628},
  publisher    = {Nature Publishing Group},
  series       = {Nature Neuroscience},
  title        = {Dyskinesias following neural transplantation in Parkinson's disease.},
  url          = {http://dx.doi.org/10.1038/nn863},
  volume       = {5},
  year         = {2002},
}