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Neurotrophins and brain insults

Lindvall, Olle LU ; Kokaia, Zaal LU ; Bengzon, Johan LU ; Elmer, Eskil LU and Kokaia, Merab LU (1994) In Trends in Neurosciences 17(11). p.490-496
Abstract
Epileptic, hypoglycaemic, ischaemic and traumatic insults to the brain induce marked changes of gene expression for the neurotrophins, nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, and their high-affinity receptors, TrkB and TrkC, in cortical and hippocampal neurones. Release of glutamate and influx of Ca2+ are the most important triggering factors. The major hypotheses for the functional effects of the insult-induced neurotrophin changes are protection against neuronal damage and stimulation of sprouting and synaptic reorganization. More insight into the regulation and role of the neurotrophins after brain insults should increase our understanding of pathophysiological mechanisms in, for example,... (More)
Epileptic, hypoglycaemic, ischaemic and traumatic insults to the brain induce marked changes of gene expression for the neurotrophins, nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, and their high-affinity receptors, TrkB and TrkC, in cortical and hippocampal neurones. Release of glutamate and influx of Ca2+ are the most important triggering factors. The major hypotheses for the functional effects of the insult-induced neurotrophin changes are protection against neuronal damage and stimulation of sprouting and synaptic reorganization. More insight into the regulation and role of the neurotrophins after brain insults should increase our understanding of pathophysiological mechanisms in, for example, epileptogenesis and cell death, and could lead to new therapeutic strategies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Neurosciences
volume
17
issue
11
pages
490 - 496
publisher
Elsevier
external identifiers
  • pmid:7531892
  • scopus:0028088818
ISSN
1878-108X
DOI
10.1016/0166-2236(94)90139-2
language
English
LU publication?
yes
id
f0780d2c-5f64-4cb2-9e7b-e968d980518b (old id 1108187)
date added to LUP
2008-07-23 15:14:33
date last changed
2017-08-06 04:29:20
@article{f0780d2c-5f64-4cb2-9e7b-e968d980518b,
  abstract     = {Epileptic, hypoglycaemic, ischaemic and traumatic insults to the brain induce marked changes of gene expression for the neurotrophins, nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, and their high-affinity receptors, TrkB and TrkC, in cortical and hippocampal neurones. Release of glutamate and influx of Ca2+ are the most important triggering factors. The major hypotheses for the functional effects of the insult-induced neurotrophin changes are protection against neuronal damage and stimulation of sprouting and synaptic reorganization. More insight into the regulation and role of the neurotrophins after brain insults should increase our understanding of pathophysiological mechanisms in, for example, epileptogenesis and cell death, and could lead to new therapeutic strategies.},
  author       = {Lindvall, Olle and Kokaia, Zaal and Bengzon, Johan and Elmer, Eskil and Kokaia, Merab},
  issn         = {1878-108X},
  language     = {eng},
  number       = {11},
  pages        = {490--496},
  publisher    = {Elsevier},
  series       = {Trends in Neurosciences},
  title        = {Neurotrophins and brain insults},
  url          = {http://dx.doi.org/10.1016/0166-2236(94)90139-2},
  volume       = {17},
  year         = {1994},
}