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Co-expression of TrkB and TrkC receptors in CNS neurones suggests regulation by multiple neurotrophins

Kokaia, Zaal LU ; Metsis, Madis; Kokaia, Merab LU ; Elmer, Eskil LU and Lindvall, Olle LU (1995) In NeuroReport 6(5). p.769-772
Abstract
Using double-label in situ hybridization, we have explored the possibility that individual CNS neurones can co-express mRNAs for the high-affinity receptors of brain-derived neurotrophic factor and neurotrophin-3, TrkB and TrkC, respectively. The vast majority of TrkC mRNA-containing neurones in the hippocampal formation and cerebral cortex were also labelled for TrkB mRNA. Cells expressing only TrkB or TrkC mRNA were very scarce in these regions, representing < 15% of all labelled cells. These findings suggest that the same cortical or hippocampal neurone can be regulated by several members of the neurotrophin family, which may be important both during development and in response to physiological activity and pathological conditions.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
6
issue
5
pages
769 - 772
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:7605945
ISSN
1473-558X
language
English
LU publication?
yes
id
8f1c4283-e2a8-4a3d-89cb-28bb41f7233d (old id 1109370)
date added to LUP
2008-07-28 13:39:25
date last changed
2016-04-15 19:53:10
@article{8f1c4283-e2a8-4a3d-89cb-28bb41f7233d,
  abstract     = {Using double-label in situ hybridization, we have explored the possibility that individual CNS neurones can co-express mRNAs for the high-affinity receptors of brain-derived neurotrophic factor and neurotrophin-3, TrkB and TrkC, respectively. The vast majority of TrkC mRNA-containing neurones in the hippocampal formation and cerebral cortex were also labelled for TrkB mRNA. Cells expressing only TrkB or TrkC mRNA were very scarce in these regions, representing &lt; 15% of all labelled cells. These findings suggest that the same cortical or hippocampal neurone can be regulated by several members of the neurotrophin family, which may be important both during development and in response to physiological activity and pathological conditions.},
  author       = {Kokaia, Zaal and Metsis, Madis and Kokaia, Merab and Elmer, Eskil and Lindvall, Olle},
  issn         = {1473-558X},
  language     = {eng},
  number       = {5},
  pages        = {769--772},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Co-expression of TrkB and TrkC receptors in CNS neurones suggests regulation by multiple neurotrophins},
  volume       = {6},
  year         = {1995},
}