Regulation of neuronal nitric oxide synthase mRNA levels in rat brain by seizure activity
(1996) In NeuroReport 7(7). p.1335-1335- Abstract
- The regulation of neuronal nitric oxide synthase (NOS) mRNA levels during kindling epileptogenesis in the rat brain was investigated using in situ hybridization. Following 40 rapidly recurring seizures evoked by hippocampal stimulations, NOS mRNA expression decreased by 56% in the dentate granule cell layer (maximum at 2 h) and increased by 420,105 and 1260% in the CA1 and CA3 pyramidal layers and piriform cortex, respectively (maximum at 12-24 h). Gene expression had returned to control levels after one week. The presumed alterations of nitric oxide production, following the changes in NOS mRNA shown here, may modulate synaptic function during kindling development, and could influence neuronal vulnerability after epileptic insults.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1110526
- author
- Elmer, Eskil LU ; Alm, Per ; Kokaia, Zaal LU ; Kokaia, Merab LU ; Larsson, Bengt ; Keep, Marcus ; Andersson, Karl-Erik and Lindvall, Olle LU
- organization
- publishing date
- 1996
- type
- Contribution to journal
- publication status
- published
- subject
- in
- NeuroReport
- volume
- 7
- issue
- 7
- pages
- 1335 - 1335
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:8817561
- scopus:0029683115
- ISSN
- 1473-558X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Restorative Neurology (0131000160), Neurology, Lund (013027000), Laboratory for Experimental Brain Research (013041000)
- id
- d31cfd36-3fd4-435a-b0af-223386853d53 (old id 1110526)
- date added to LUP
- 2016-04-01 11:58:37
- date last changed
- 2022-01-26 21:00:37
@article{d31cfd36-3fd4-435a-b0af-223386853d53, abstract = {{The regulation of neuronal nitric oxide synthase (NOS) mRNA levels during kindling epileptogenesis in the rat brain was investigated using in situ hybridization. Following 40 rapidly recurring seizures evoked by hippocampal stimulations, NOS mRNA expression decreased by 56% in the dentate granule cell layer (maximum at 2 h) and increased by 420,105 and 1260% in the CA1 and CA3 pyramidal layers and piriform cortex, respectively (maximum at 12-24 h). Gene expression had returned to control levels after one week. The presumed alterations of nitric oxide production, following the changes in NOS mRNA shown here, may modulate synaptic function during kindling development, and could influence neuronal vulnerability after epileptic insults.}}, author = {{Elmer, Eskil and Alm, Per and Kokaia, Zaal and Kokaia, Merab and Larsson, Bengt and Keep, Marcus and Andersson, Karl-Erik and Lindvall, Olle}}, issn = {{1473-558X}}, language = {{eng}}, number = {{7}}, pages = {{1335--1335}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{NeuroReport}}, title = {{Regulation of neuronal nitric oxide synthase mRNA levels in rat brain by seizure activity}}, volume = {{7}}, year = {{1996}}, }