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Regulation of neuronal nitric oxide synthase mRNA levels in rat brain by seizure activity

Elmer, Eskil LU ; Alm, Per; Kokaia, Zaal LU ; Kokaia, Merab LU ; Larsson, Bengt; Keep, Marcus; Andersson, Karl-Erik and Lindvall, Olle LU (1996) In NeuroReport 7(7). p.1335-1335
Abstract
The regulation of neuronal nitric oxide synthase (NOS) mRNA levels during kindling epileptogenesis in the rat brain was investigated using in situ hybridization. Following 40 rapidly recurring seizures evoked by hippocampal stimulations, NOS mRNA expression decreased by 56% in the dentate granule cell layer (maximum at 2 h) and increased by 420,105 and 1260% in the CA1 and CA3 pyramidal layers and piriform cortex, respectively (maximum at 12-24 h). Gene expression had returned to control levels after one week. The presumed alterations of nitric oxide production, following the changes in NOS mRNA shown here, may modulate synaptic function during kindling development, and could influence neuronal vulnerability after epileptic insults.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
7
issue
7
pages
1335 - 1335
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:8817561
  • scopus:0029683115
ISSN
1473-558X
language
English
LU publication?
yes
id
d31cfd36-3fd4-435a-b0af-223386853d53 (old id 1110526)
date added to LUP
2008-07-23 09:04:04
date last changed
2017-01-01 04:43:14
@article{d31cfd36-3fd4-435a-b0af-223386853d53,
  abstract     = {The regulation of neuronal nitric oxide synthase (NOS) mRNA levels during kindling epileptogenesis in the rat brain was investigated using in situ hybridization. Following 40 rapidly recurring seizures evoked by hippocampal stimulations, NOS mRNA expression decreased by 56% in the dentate granule cell layer (maximum at 2 h) and increased by 420,105 and 1260% in the CA1 and CA3 pyramidal layers and piriform cortex, respectively (maximum at 12-24 h). Gene expression had returned to control levels after one week. The presumed alterations of nitric oxide production, following the changes in NOS mRNA shown here, may modulate synaptic function during kindling development, and could influence neuronal vulnerability after epileptic insults.},
  author       = {Elmer, Eskil and Alm, Per and Kokaia, Zaal and Kokaia, Merab and Larsson, Bengt and Keep, Marcus and Andersson, Karl-Erik and Lindvall, Olle},
  issn         = {1473-558X},
  language     = {eng},
  number       = {7},
  pages        = {1335--1335},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Regulation of neuronal nitric oxide synthase mRNA levels in rat brain by seizure activity},
  volume       = {7},
  year         = {1996},
}