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Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease

Wenning, Gregor K; Odin, Per; Morrish, Paul; Rehncrona, Stig LU ; Widner, Håkan LU ; Brundin, Patrik LU ; Rothwell, John C; Brown, Richard; Gustavii, Björn LU and Hagell, Peter LU , et al. (1997) In Annals of Neurology 42(1). p.95-107
Abstract
Six patients with Parkinson's disease were followed for 10 to 72 months after human embryonic mesencephalic tissue from four to seven donors was grafted unilaterally into the putamen (4 patients) or putamen plus caudate (2 patients). After 8 to 12 months, positron emission tomography showed a 68% increase of 6-L-[18F]-fluorodopa uptake in the grafted putamen, no change in the grafted caudate, and minor decreases in nongrafted striatal regions. There was therapeutically valuable improvement in 4 patients, but only modest changes in the other 2, both of whom developed atypical features. Patient 4 was without L-dopa from 32 months and had normal fluorodopa uptake in the grafted putamen at 72 months. Overall, the L-dopa dose was reduced by a... (More)
Six patients with Parkinson's disease were followed for 10 to 72 months after human embryonic mesencephalic tissue from four to seven donors was grafted unilaterally into the putamen (4 patients) or putamen plus caudate (2 patients). After 8 to 12 months, positron emission tomography showed a 68% increase of 6-L-[18F]-fluorodopa uptake in the grafted putamen, no change in the grafted caudate, and minor decreases in nongrafted striatal regions. There was therapeutically valuable improvement in 4 patients, but only modest changes in the other 2, both of whom developed atypical features. Patient 4 was without L-dopa from 32 months and had normal fluorodopa uptake in the grafted putamen at 72 months. Overall, the L-dopa dose was reduced by a mean of 10 and 20%, "off" time was reduced by 34 and 44%, and the "off" phase Unified Parkinson's Disease Rating Scale motor score by 18 and 26%, and the duration of the response to a single L-dopa dose increased by 45 and 58% during the first and second years after surgery, respectively. Rigidity and hypokinesia improved bilaterally, but mainly contralateral to the implant. No consistent changes in dyskinesias were observed. We conclude that transplantation of embryonic mesencephalic tissue leads to highly reproducible survival of dopaminergic neurons, inducing clinically valuable improvements in most recipients. (Less)
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Annals of Neurology
volume
42
issue
1
pages
95 - 107
publisher
John Wiley and Sons Inc.
external identifiers
  • pmid:9225690
  • scopus:0030834093
ISSN
1531-8249
DOI
10.1002/ana.410420115
language
English
LU publication?
yes
id
b368bf0b-3729-4650-8e8f-5615b0b7deda (old id 1111559)
date added to LUP
2008-07-17 16:11:42
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2017-08-13 03:41:34
@article{b368bf0b-3729-4650-8e8f-5615b0b7deda,
  abstract     = {Six patients with Parkinson's disease were followed for 10 to 72 months after human embryonic mesencephalic tissue from four to seven donors was grafted unilaterally into the putamen (4 patients) or putamen plus caudate (2 patients). After 8 to 12 months, positron emission tomography showed a 68% increase of 6-L-[18F]-fluorodopa uptake in the grafted putamen, no change in the grafted caudate, and minor decreases in nongrafted striatal regions. There was therapeutically valuable improvement in 4 patients, but only modest changes in the other 2, both of whom developed atypical features. Patient 4 was without L-dopa from 32 months and had normal fluorodopa uptake in the grafted putamen at 72 months. Overall, the L-dopa dose was reduced by a mean of 10 and 20%, "off" time was reduced by 34 and 44%, and the "off" phase Unified Parkinson's Disease Rating Scale motor score by 18 and 26%, and the duration of the response to a single L-dopa dose increased by 45 and 58% during the first and second years after surgery, respectively. Rigidity and hypokinesia improved bilaterally, but mainly contralateral to the implant. No consistent changes in dyskinesias were observed. We conclude that transplantation of embryonic mesencephalic tissue leads to highly reproducible survival of dopaminergic neurons, inducing clinically valuable improvements in most recipients.},
  author       = {Wenning, Gregor K and Odin, Per and Morrish, Paul and Rehncrona, Stig and Widner, Håkan and Brundin, Patrik and Rothwell, John C and Brown, Richard and Gustavii, Björn and Hagell, Peter and Jahanshahi, Marjan and Sawle, Guy and Björklund, Anders and Brooks, David J and Marsden, C David and Quinn, Niall P and Lindvall, Olle},
  issn         = {1531-8249},
  language     = {eng},
  number       = {1},
  pages        = {95--107},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Annals of Neurology},
  title        = {Short- and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease},
  url          = {http://dx.doi.org/10.1002/ana.410420115},
  volume       = {42},
  year         = {1997},
}