Mossy fibre sprouting: evidence against a facilitatory role in epileptogenesis
Elmer, Eskil LU
; Kokaia, Zaal
LU
; Kokaia, Merab
LU
; Lindvall, Olle
LU
and McIntyre, Dan C
(1997)
In NeuroReport
8(5).
p.1193-1196
- Abstract
- Sprouting of mossy fibres from dentate granule cells occurs in several animal models of epilepsy and in epileptic humans. Mossy fibre sprouting might contribute to epileptogenesis but also could be a compensatory, inhibitory response. We analysed mossy fibre sprouting in the supragranular zone of the dentate gyrus using Timm's histochemical method in genetically fast and slow kindling rats. Before the start of amygdala kindling, the slow rats showed higher Timm's staining scores than did the fast kindlers. No increase of mossy fibre density was observed when the animals were stimulated until either the fast or the slow rats had reached the fully kindled state. Our data argue against the hypothesis that mossy fibre sprouting facilitates... (More)
- Sprouting of mossy fibres from dentate granule cells occurs in several animal models of epilepsy and in epileptic humans. Mossy fibre sprouting might contribute to epileptogenesis but also could be a compensatory, inhibitory response. We analysed mossy fibre sprouting in the supragranular zone of the dentate gyrus using Timm's histochemical method in genetically fast and slow kindling rats. Before the start of amygdala kindling, the slow rats showed higher Timm's staining scores than did the fast kindlers. No increase of mossy fibre density was observed when the animals were stimulated until either the fast or the slow rats had reached the fully kindled state. Our data argue against the hypothesis that mossy fibre sprouting facilitates epileptogenesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111963
- author
- Elmer, Eskil
LU
; Kokaia, Zaal
LU
; Kokaia, Merab
LU
; Lindvall, Olle
LU
and McIntyre, Dan C
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- in
- NeuroReport
- volume
- 8
- issue
- 5
- pages
- 1193 - 1196
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:9175112
- scopus:0030914574
- ISSN
- 1473-558X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Laboratory for Experimental Brain Research (013041000), Neurology, Lund (013027000)
- id
- e6e7538c-c336-4c38-bd9a-10c6fa6c5e73 (old id 1111963)
- date added to LUP
- 2016-04-01 11:37:10
- date last changed
- 2022-04-05 02:24:31
@article{e6e7538c-c336-4c38-bd9a-10c6fa6c5e73,
abstract = {{Sprouting of mossy fibres from dentate granule cells occurs in several animal models of epilepsy and in epileptic humans. Mossy fibre sprouting might contribute to epileptogenesis but also could be a compensatory, inhibitory response. We analysed mossy fibre sprouting in the supragranular zone of the dentate gyrus using Timm's histochemical method in genetically fast and slow kindling rats. Before the start of amygdala kindling, the slow rats showed higher Timm's staining scores than did the fast kindlers. No increase of mossy fibre density was observed when the animals were stimulated until either the fast or the slow rats had reached the fully kindled state. Our data argue against the hypothesis that mossy fibre sprouting facilitates epileptogenesis.}},
author = {{Elmer, Eskil and Kokaia, Zaal and Kokaia, Merab and Lindvall, Olle and McIntyre, Dan C}},
issn = {{1473-558X}},
language = {{eng}},
number = {{5}},
pages = {{1193--1196}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{NeuroReport}},
title = {{Mossy fibre sprouting: evidence against a facilitatory role in epileptogenesis}},
volume = {{8}},
year = {{1997}},
}