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Mossy fibre sprouting: evidence against a facilitatory role in epileptogenesis

Elmer, Eskil LU ; Kokaia, Zaal LU ; Kokaia, Merab LU ; Lindvall, Olle LU and McIntyre, Dan C (1997) In NeuroReport 8(5). p.1193-1196
Abstract
Sprouting of mossy fibres from dentate granule cells occurs in several animal models of epilepsy and in epileptic humans. Mossy fibre sprouting might contribute to epileptogenesis but also could be a compensatory, inhibitory response. We analysed mossy fibre sprouting in the supragranular zone of the dentate gyrus using Timm's histochemical method in genetically fast and slow kindling rats. Before the start of amygdala kindling, the slow rats showed higher Timm's staining scores than did the fast kindlers. No increase of mossy fibre density was observed when the animals were stimulated until either the fast or the slow rats had reached the fully kindled state. Our data argue against the hypothesis that mossy fibre sprouting facilitates... (More)
Sprouting of mossy fibres from dentate granule cells occurs in several animal models of epilepsy and in epileptic humans. Mossy fibre sprouting might contribute to epileptogenesis but also could be a compensatory, inhibitory response. We analysed mossy fibre sprouting in the supragranular zone of the dentate gyrus using Timm's histochemical method in genetically fast and slow kindling rats. Before the start of amygdala kindling, the slow rats showed higher Timm's staining scores than did the fast kindlers. No increase of mossy fibre density was observed when the animals were stimulated until either the fast or the slow rats had reached the fully kindled state. Our data argue against the hypothesis that mossy fibre sprouting facilitates epileptogenesis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
NeuroReport
volume
8
issue
5
pages
1193 - 1196
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:9175112
  • scopus:0030914574
ISSN
1473-558X
language
English
LU publication?
yes
id
e6e7538c-c336-4c38-bd9a-10c6fa6c5e73 (old id 1111963)
date added to LUP
2008-07-21 10:56:04
date last changed
2017-09-03 03:36:30
@article{e6e7538c-c336-4c38-bd9a-10c6fa6c5e73,
  abstract     = {Sprouting of mossy fibres from dentate granule cells occurs in several animal models of epilepsy and in epileptic humans. Mossy fibre sprouting might contribute to epileptogenesis but also could be a compensatory, inhibitory response. We analysed mossy fibre sprouting in the supragranular zone of the dentate gyrus using Timm's histochemical method in genetically fast and slow kindling rats. Before the start of amygdala kindling, the slow rats showed higher Timm's staining scores than did the fast kindlers. No increase of mossy fibre density was observed when the animals were stimulated until either the fast or the slow rats had reached the fully kindled state. Our data argue against the hypothesis that mossy fibre sprouting facilitates epileptogenesis.},
  author       = {Elmer, Eskil and Kokaia, Zaal and Kokaia, Merab and Lindvall, Olle and McIntyre, Dan C},
  issn         = {1473-558X},
  language     = {eng},
  number       = {5},
  pages        = {1193--1196},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {NeuroReport},
  title        = {Mossy fibre sprouting: evidence against a facilitatory role in epileptogenesis},
  volume       = {8},
  year         = {1997},
}