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Dynamic changes of brain-derived neurotrophic factor protein levels in the rat forebrain after single and recurring kindling-induced seizures

Elmer, Eskil LU ; Kokaia, Zaal LU ; Kokaia, Merab LU ; Carnahan, J; Nawa, H and Lindvall, Olle LU (1998) In Neuroscience 83(2). p.351-362
Abstract
Regional levels of brain-derived neurotrophic factor protein were measured in the rat brain using enzyme immunoassay following seizures evoked by hippocampal kindling stimulations. One stimulation, which induced a brief, single episode of epileptiform activity in hippocampus and piriform cortex but not in parietal cortex or striatum, gave rise to a transient increase of brain-derived neurotrophic factor levels in dentate gyrus and CA3 region and a decrease in piriform cortex. After 40 rapidly recurring seizures, with epileptiform activity also involving parietal cortex and striatum, increases were observed in dentate gyrus, CA3 and CA1 regions, piriform cortex and striatum. Maximum levels were reached at 2-24 h and brain-derived... (More)
Regional levels of brain-derived neurotrophic factor protein were measured in the rat brain using enzyme immunoassay following seizures evoked by hippocampal kindling stimulations. One stimulation, which induced a brief, single episode of epileptiform activity in hippocampus and piriform cortex but not in parietal cortex or striatum, gave rise to a transient increase of brain-derived neurotrophic factor levels in dentate gyrus and CA3 region and a decrease in piriform cortex. After 40 rapidly recurring seizures, with epileptiform activity also involving parietal cortex and striatum, increases were observed in dentate gyrus, CA3 and CA1 regions, piriform cortex and striatum. Maximum levels were reached at 2-24 h and brain-derived neurotrophic factor then returned to baseline except in dentate gyrus, where elevated protein content was sustained for four days. The differential regulation of brain-derived neurotrophic factor protein levels in various forebrain structures, which only partly correlates to messenger RNA changes, could indicate regional differences in protein release, antero- or retrograde transport, or brain-derived neurotrophic factor promotor activation. The dynamic changes of brain-derived neurotrophic factor levels in regions involved in the generation and spread of seizure activity may regulate excitability and trigger plastic responses in the post-seizure period. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
enzyme immunoassay, neurotrophins, hippocampus, epilepsy
in
Neuroscience
volume
83
issue
2
pages
351 - 362
publisher
Elsevier
external identifiers
  • pmid:9460745
  • scopus:0031929925
ISSN
1873-7544
DOI
10.1016/S0306-4522(97)00387-4
language
English
LU publication?
yes
id
fa607466-a869-45fa-a472-c91b5f3985ae (old id 1113350)
date added to LUP
2008-07-14 16:45:15
date last changed
2017-01-01 04:22:36
@article{fa607466-a869-45fa-a472-c91b5f3985ae,
  abstract     = {Regional levels of brain-derived neurotrophic factor protein were measured in the rat brain using enzyme immunoassay following seizures evoked by hippocampal kindling stimulations. One stimulation, which induced a brief, single episode of epileptiform activity in hippocampus and piriform cortex but not in parietal cortex or striatum, gave rise to a transient increase of brain-derived neurotrophic factor levels in dentate gyrus and CA3 region and a decrease in piriform cortex. After 40 rapidly recurring seizures, with epileptiform activity also involving parietal cortex and striatum, increases were observed in dentate gyrus, CA3 and CA1 regions, piriform cortex and striatum. Maximum levels were reached at 2-24 h and brain-derived neurotrophic factor then returned to baseline except in dentate gyrus, where elevated protein content was sustained for four days. The differential regulation of brain-derived neurotrophic factor protein levels in various forebrain structures, which only partly correlates to messenger RNA changes, could indicate regional differences in protein release, antero- or retrograde transport, or brain-derived neurotrophic factor promotor activation. The dynamic changes of brain-derived neurotrophic factor levels in regions involved in the generation and spread of seizure activity may regulate excitability and trigger plastic responses in the post-seizure period.},
  author       = {Elmer, Eskil and Kokaia, Zaal and Kokaia, Merab and Carnahan, J and Nawa, H and Lindvall, Olle},
  issn         = {1873-7544},
  keyword      = {enzyme immunoassay,neurotrophins,hippocampus,epilepsy},
  language     = {eng},
  number       = {2},
  pages        = {351--362},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Dynamic changes of brain-derived neurotrophic factor protein levels in the rat forebrain after single and recurring kindling-induced seizures},
  url          = {http://dx.doi.org/10.1016/S0306-4522(97)00387-4},
  volume       = {83},
  year         = {1998},
}