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Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient

Piccini, P; Brooks, D J; Björklund, Anders LU ; Gunn, R N; Grasby, P M; Rimoldi, O; Brundin, Patrik LU ; Hagell, Peter LU ; Rehncrona, Stig LU and Widner, Håkan LU , et al. (1999) In Nature Neuroscience 2(12). p.1137-1140
Abstract
Synaptic dopamine release from embryonic nigral transplants has been monitored in the striatum of a patient with Parkinson's disease using [11C]-raclopride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmitter. In this patient, who had received a transplant in the right putamen 10 years earlier, grafts had restored both basal and drug-induced dopamine release to normal levels. This was associated with sustained, marked clinical benefit and normalized levels of dopamine storage in the grafted putamen. Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief.
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Contribution to journal
publication status
published
subject
in
Nature Neuroscience
volume
2
issue
12
pages
1137 - 1140
publisher
Nature Publishing Group
external identifiers
  • pmid:10570493
  • scopus:0033491121
ISSN
1546-1726
DOI
10.1038/16060
language
English
LU publication?
yes
id
19d0c1fa-7f8c-40c9-9160-14ff2c4b596b (old id 1114594)
date added to LUP
2008-07-04 14:11:20
date last changed
2017-08-06 04:39:47
@article{19d0c1fa-7f8c-40c9-9160-14ff2c4b596b,
  abstract     = {Synaptic dopamine release from embryonic nigral transplants has been monitored in the striatum of a patient with Parkinson's disease using [11C]-raclopride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmitter. In this patient, who had received a transplant in the right putamen 10 years earlier, grafts had restored both basal and drug-induced dopamine release to normal levels. This was associated with sustained, marked clinical benefit and normalized levels of dopamine storage in the grafted putamen. Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief.},
  author       = {Piccini, P and Brooks, D J and Björklund, Anders and Gunn, R N and Grasby, P M and Rimoldi, O and Brundin, Patrik and Hagell, Peter and Rehncrona, Stig and Widner, Håkan and Lindvall, Olle},
  issn         = {1546-1726},
  language     = {eng},
  number       = {12},
  pages        = {1137--1140},
  publisher    = {Nature Publishing Group},
  series       = {Nature Neuroscience},
  title        = {Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient},
  url          = {http://dx.doi.org/10.1038/16060},
  volume       = {2},
  year         = {1999},
}