Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient
Piccini, P ; Brooks, D J ; Björklund, Anders LU
; Gunn, R N
; Grasby, P M
; Rimoldi, O
; Brundin, Patrik
LU
; Hagell, Peter
LU
; Rehncrona, Stig
LU
and Widner, Håkan
LU
, et al.
(1999)
In Nature Neuroscience
2(12).
p.1137-1140
- Abstract
- Synaptic dopamine release from embryonic nigral transplants has been monitored in the striatum of a patient with Parkinson's disease using [11C]-raclopride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmitter. In this patient, who had received a transplant in the right putamen 10 years earlier, grafts had restored both basal and drug-induced dopamine release to normal levels. This was associated with sustained, marked clinical benefit and normalized levels of dopamine storage in the grafted putamen. Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1114594
- author
- Piccini, P
; Brooks, D J
; Björklund, Anders
LU
; Gunn, R N
; Grasby, P M
; Rimoldi, O
; Brundin, Patrik
LU
; Hagell, Peter
LU
; Rehncrona, Stig
LU
and Widner, Håkan
LU
, et al. (More)
- Piccini, P
; Brooks, D J
; Björklund, Anders
LU
; Gunn, R N
; Grasby, P M
; Rimoldi, O
; Brundin, Patrik
LU
; Hagell, Peter
LU
; Rehncrona, Stig
LU
; Widner, Håkan
LU
and Lindvall, Olle
LU
(Less)
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Neuroscience
- volume
- 2
- issue
- 12
- pages
- 1137 - 1140
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:10570493
- scopus:0033491121
- ISSN
- 1546-1726
- DOI
- 10.1038/16060
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neurology, Lund (013027000), Neurosurgery (013026000), Neurobiology (013212024), Older people’s health and Person-Centred care (013220012)
- id
- 19d0c1fa-7f8c-40c9-9160-14ff2c4b596b (old id 1114594)
- date added to LUP
- 2016-04-01 16:56:53
- date last changed
- 2022-04-15 08:09:58
@article{19d0c1fa-7f8c-40c9-9160-14ff2c4b596b,
abstract = {{Synaptic dopamine release from embryonic nigral transplants has been monitored in the striatum of a patient with Parkinson's disease using [11C]-raclopride positron emission tomography to measure dopamine D2 receptor occupancy by the endogenous transmitter. In this patient, who had received a transplant in the right putamen 10 years earlier, grafts had restored both basal and drug-induced dopamine release to normal levels. This was associated with sustained, marked clinical benefit and normalized levels of dopamine storage in the grafted putamen. Despite an ongoing disease process, grafted neurons can thus continue for a decade to store and release dopamine and give rise to substantial symptomatic relief.}},
author = {{Piccini, P and Brooks, D J and Björklund, Anders and Gunn, R N and Grasby, P M and Rimoldi, O and Brundin, Patrik and Hagell, Peter and Rehncrona, Stig and Widner, Håkan and Lindvall, Olle}},
issn = {{1546-1726}},
language = {{eng}},
number = {{12}},
pages = {{1137--1140}},
publisher = {{Nature Publishing Group}},
series = {{Nature Neuroscience}},
title = {{Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient}},
url = {{http://dx.doi.org/10.1038/16060}},
doi = {{10.1038/16060}},
volume = {{2}},
year = {{1999}},
}