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Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts

Piccini, P; Lindvall, Olle LU ; Björklund, Anders LU ; Brundin, Patrik LU ; Hagell, Peter LU ; Ceravolo, R; Oertel, W; Quinn, N; Samuel, M and Rehncrona, Stig LU , et al. (2000) In Annals of Neurology 48(5). p.689-695
Abstract
Intrastriatal transplantation of dopaminergic neurones aims to repair the selective loss of nigrostriatal projections and the consequent dysfunction of striatocortical circuitries in Parkinson's disease (PD). Here, we have studied the effects of bilateral human embryonic dopaminergic grafts on the movement-related activation of frontal cortical areas in 4 PD patients using H2 15O positron emission tomography and a joystick movement task. At 6.5 months after transplantation, mean striatal dopamine storage capacity as measured by 18F-dopa positron emission tomography was already significantly elevated in these patients. This was associated with a modest clinical improvement on the Unified Parkinson's Disease Rating Scale, whereas the... (More)
Intrastriatal transplantation of dopaminergic neurones aims to repair the selective loss of nigrostriatal projections and the consequent dysfunction of striatocortical circuitries in Parkinson's disease (PD). Here, we have studied the effects of bilateral human embryonic dopaminergic grafts on the movement-related activation of frontal cortical areas in 4 PD patients using H2 15O positron emission tomography and a joystick movement task. At 6.5 months after transplantation, mean striatal dopamine storage capacity as measured by 18F-dopa positron emission tomography was already significantly elevated in these patients. This was associated with a modest clinical improvement on the Unified Parkinson's Disease Rating Scale, whereas the impaired cortical activation was unchanged. At 18 months after surgery, there was further significant clinical improvement in the absence of any additional increase in striatal 18F-dopa uptake. Rostral supplementary motor and dorsal prefrontal cortical activation during performance of joystick movements had significantly improved, however. Our data suggest that the function of the graft goes beyond that of a simple dopamine delivery system and that functional integration of the grafted neurones within the host brain is necessary to produce substantial clinical recovery in PD. (Less)
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Annals of Neurology
volume
48
issue
5
pages
689 - 695
publisher
John Wiley and Sons Inc.
external identifiers
  • pmid:11079531
  • scopus:0033767269
ISSN
1531-8249
DOI
10.1002/1531-8249(200011)48:5<689::AID-ANA1>3.0.CO;2-N
language
English
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yes
id
97c00cd1-07f7-43e0-8a7b-1a7f70f67f00 (old id 1116990)
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2008-07-02 14:37:45
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2017-03-26 03:25:48
@article{97c00cd1-07f7-43e0-8a7b-1a7f70f67f00,
  abstract     = {Intrastriatal transplantation of dopaminergic neurones aims to repair the selective loss of nigrostriatal projections and the consequent dysfunction of striatocortical circuitries in Parkinson's disease (PD). Here, we have studied the effects of bilateral human embryonic dopaminergic grafts on the movement-related activation of frontal cortical areas in 4 PD patients using H2 15O positron emission tomography and a joystick movement task. At 6.5 months after transplantation, mean striatal dopamine storage capacity as measured by 18F-dopa positron emission tomography was already significantly elevated in these patients. This was associated with a modest clinical improvement on the Unified Parkinson's Disease Rating Scale, whereas the impaired cortical activation was unchanged. At 18 months after surgery, there was further significant clinical improvement in the absence of any additional increase in striatal 18F-dopa uptake. Rostral supplementary motor and dorsal prefrontal cortical activation during performance of joystick movements had significantly improved, however. Our data suggest that the function of the graft goes beyond that of a simple dopamine delivery system and that functional integration of the grafted neurones within the host brain is necessary to produce substantial clinical recovery in PD.},
  author       = {Piccini, P and Lindvall, Olle and Björklund, Anders and Brundin, Patrik and Hagell, Peter and Ceravolo, R and Oertel, W and Quinn, N and Samuel, M and Rehncrona, Stig and Widner, Håkan and Brooks, D J},
  issn         = {1531-8249},
  language     = {eng},
  number       = {5},
  pages        = {689--695},
  publisher    = {John Wiley and Sons Inc.},
  series       = {Annals of Neurology},
  title        = {Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts},
  url          = {http://dx.doi.org/10.1002/1531-8249(200011)48:5<689::AID-ANA1>3.0.CO;2-N},
  volume       = {48},
  year         = {2000},
}