Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts
Piccini, P ; Lindvall, Olle LU ; Björklund, Anders LU
; Brundin, Patrik
LU
; Hagell, Peter
LU
; Ceravolo, R
; Oertel, W
; Quinn, N
; Samuel, M
and Rehncrona, Stig
LU
, et al.
(2000)
In Annals of Neurology
48(5).
p.689-695
- Abstract
- Intrastriatal transplantation of dopaminergic neurones aims to repair the selective loss of nigrostriatal projections and the consequent dysfunction of striatocortical circuitries in Parkinson's disease (PD). Here, we have studied the effects of bilateral human embryonic dopaminergic grafts on the movement-related activation of frontal cortical areas in 4 PD patients using H2 15O positron emission tomography and a joystick movement task. At 6.5 months after transplantation, mean striatal dopamine storage capacity as measured by 18F-dopa positron emission tomography was already significantly elevated in these patients. This was associated with a modest clinical improvement on the Unified Parkinson's Disease Rating Scale, whereas the... (More)
- Intrastriatal transplantation of dopaminergic neurones aims to repair the selective loss of nigrostriatal projections and the consequent dysfunction of striatocortical circuitries in Parkinson's disease (PD). Here, we have studied the effects of bilateral human embryonic dopaminergic grafts on the movement-related activation of frontal cortical areas in 4 PD patients using H2 15O positron emission tomography and a joystick movement task. At 6.5 months after transplantation, mean striatal dopamine storage capacity as measured by 18F-dopa positron emission tomography was already significantly elevated in these patients. This was associated with a modest clinical improvement on the Unified Parkinson's Disease Rating Scale, whereas the impaired cortical activation was unchanged. At 18 months after surgery, there was further significant clinical improvement in the absence of any additional increase in striatal 18F-dopa uptake. Rostral supplementary motor and dorsal prefrontal cortical activation during performance of joystick movements had significantly improved, however. Our data suggest that the function of the graft goes beyond that of a simple dopamine delivery system and that functional integration of the grafted neurones within the host brain is necessary to produce substantial clinical recovery in PD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1116990
- author
- Piccini, P
; Lindvall, Olle
LU
; Björklund, Anders
LU
; Brundin, Patrik
LU
; Hagell, Peter
LU
; Ceravolo, R
; Oertel, W
; Quinn, N
; Samuel, M
and Rehncrona, Stig
LU
, et al. (More)
- Piccini, P
; Lindvall, Olle
LU
; Björklund, Anders
LU
; Brundin, Patrik
LU
; Hagell, Peter
LU
; Ceravolo, R
; Oertel, W
; Quinn, N
; Samuel, M
; Rehncrona, Stig
LU
; Widner, Håkan
LU
and Brooks, D J
(Less)
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Annals of Neurology
- volume
- 48
- issue
- 5
- pages
- 689 - 695
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:11079531
- scopus:0033767269
- ISSN
- 1531-8249
- DOI
- 10.1002/1531-8249(200011)48:5<689::AID-ANA1>3.0.CO;2-N
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Caring Sciences (Closed 2012) (016514020), Neurobiology (013212024), Neurology, Lund (013027000), Neurosurgery (013026000), Neuronal Survival (013212041)
- id
- 97c00cd1-07f7-43e0-8a7b-1a7f70f67f00 (old id 1116990)
- date added to LUP
- 2016-04-01 11:36:33
- date last changed
- 2022-01-26 07:32:00
@article{97c00cd1-07f7-43e0-8a7b-1a7f70f67f00,
abstract = {{Intrastriatal transplantation of dopaminergic neurones aims to repair the selective loss of nigrostriatal projections and the consequent dysfunction of striatocortical circuitries in Parkinson's disease (PD). Here, we have studied the effects of bilateral human embryonic dopaminergic grafts on the movement-related activation of frontal cortical areas in 4 PD patients using H2 15O positron emission tomography and a joystick movement task. At 6.5 months after transplantation, mean striatal dopamine storage capacity as measured by 18F-dopa positron emission tomography was already significantly elevated in these patients. This was associated with a modest clinical improvement on the Unified Parkinson's Disease Rating Scale, whereas the impaired cortical activation was unchanged. At 18 months after surgery, there was further significant clinical improvement in the absence of any additional increase in striatal 18F-dopa uptake. Rostral supplementary motor and dorsal prefrontal cortical activation during performance of joystick movements had significantly improved, however. Our data suggest that the function of the graft goes beyond that of a simple dopamine delivery system and that functional integration of the grafted neurones within the host brain is necessary to produce substantial clinical recovery in PD.}},
author = {{Piccini, P and Lindvall, Olle and Björklund, Anders and Brundin, Patrik and Hagell, Peter and Ceravolo, R and Oertel, W and Quinn, N and Samuel, M and Rehncrona, Stig and Widner, Håkan and Brooks, D J}},
issn = {{1531-8249}},
language = {{eng}},
number = {{5}},
pages = {{689--695}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Annals of Neurology}},
title = {{Delayed recovery of movement-related cortical function in Parkinson's disease after striatal dopaminergic grafts}},
url = {{http://dx.doi.org/10.1002/1531-8249(200011)48:5<689::AID-ANA1>3.0.CO;2-N}},
doi = {{10.1002/1531-8249(200011)48:5<689::AID-ANA1>3.0.CO;2-N}},
volume = {{48}},
year = {{2000}},
}