Advanced

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.

Li, Jia-Yi LU ; Englund, Elisabet LU ; Holton, Janice L; Soulet, Denis LU ; Hagell, Peter LU ; Lees, Andrew J; Lashley, Tammaryn; Quinn, Niall P; Rehncrona, Stig LU and Björklund, Anders LU , et al. (2008) In Nature Medicine 14. p.501-503
Abstract
Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Medicine
volume
14
pages
501 - 503
publisher
Nature Publishing Group
external identifiers
  • WOS:000255681800028
  • PMID:18391963
  • Scopus:43249110200
ISSN
1546-170X
DOI
10.1038/nm1746
language
English
LU publication?
yes
id
9116e5d9-5773-4ad5-bc99-d9d26358de50 (old id 1147715)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18391963?dopt=Abstract
date added to LUP
2008-05-06 14:03:45
date last changed
2017-02-19 04:25:18
@article{9116e5d9-5773-4ad5-bc99-d9d26358de50,
  abstract     = {Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.},
  author       = {Li, Jia-Yi and Englund, Elisabet and Holton, Janice L and Soulet, Denis and Hagell, Peter and Lees, Andrew J and Lashley, Tammaryn and Quinn, Niall P and Rehncrona, Stig and Björklund, Anders and Widner, Håkan and Revesz, Tamas and Lindvall, Olle and Brundin, Patrik},
  issn         = {1546-170X},
  language     = {eng},
  pages        = {501--503},
  publisher    = {Nature Publishing Group},
  series       = {Nature Medicine},
  title        = {Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.},
  url          = {http://dx.doi.org/10.1038/nm1746},
  volume       = {14},
  year         = {2008},
}