Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.
Li, Jia-Yi LU ; Englund, Elisabet LU
; Holton, Janice L
; Soulet, Denis
LU
; Hagell, Peter
LU
; Lees, Andrew J
; Lashley, Tammaryn
; Quinn, Niall P
; Rehncrona, Stig
LU
and Björklund, Anders
LU
, et al.
(2008)
In Nature Medicine
14.
p.501-503
- Abstract
- Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1147715
- author
- Li, Jia-Yi
LU
; Englund, Elisabet
LU
; Holton, Janice L
; Soulet, Denis
LU
; Hagell, Peter
LU
; Lees, Andrew J
; Lashley, Tammaryn
; Quinn, Niall P
; Rehncrona, Stig
LU
and Björklund, Anders
LU
, et al. (More)
- Li, Jia-Yi
LU
; Englund, Elisabet
LU
; Holton, Janice L
; Soulet, Denis
LU
; Hagell, Peter
LU
; Lees, Andrew J
; Lashley, Tammaryn
; Quinn, Niall P
; Rehncrona, Stig
LU
; Björklund, Anders
LU
; Widner, Håkan
LU
; Revesz, Tamas
; Lindvall, Olle
LU
and Brundin, Patrik
LU
(Less)
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Medicine
- volume
- 14
- pages
- 501 - 503
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000255681800028
- pmid:18391963
- scopus:43249110200
- ISSN
- 1546-170X
- DOI
- 10.1038/nm1746
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Neurobiology (013212024), Pathology, (Lund) (013030000), Neurology, Lund (013027000), Neurosurgery (013026000), Neural Plasticity and Repair (013210080), Caring Sciences (Closed 2012) (016514020)
- id
- 9116e5d9-5773-4ad5-bc99-d9d26358de50 (old id 1147715)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/18391963?dopt=Abstract
- date added to LUP
- 2016-04-04 09:17:15
- date last changed
- 2022-04-23 19:30:26
@article{9116e5d9-5773-4ad5-bc99-d9d26358de50,
abstract = {{Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons. Our observation has key implications for understanding Parkinson's pathogenesis by providing the first evidence, to our knowledge, that the disease can propagate from host to graft cells. However, available data suggest that the majority of grafted cells are functionally unimpaired after a decade, and recipients can still experience long-term symptomatic relief.}},
author = {{Li, Jia-Yi and Englund, Elisabet and Holton, Janice L and Soulet, Denis and Hagell, Peter and Lees, Andrew J and Lashley, Tammaryn and Quinn, Niall P and Rehncrona, Stig and Björklund, Anders and Widner, Håkan and Revesz, Tamas and Lindvall, Olle and Brundin, Patrik}},
issn = {{1546-170X}},
language = {{eng}},
pages = {{501--503}},
publisher = {{Nature Publishing Group}},
series = {{Nature Medicine}},
title = {{Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.}},
url = {{http://dx.doi.org/10.1038/nm1746}},
doi = {{10.1038/nm1746}},
volume = {{14}},
year = {{2008}},
}