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Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Vesper, Hubert W.; Slimani, Nadia; Hallmans, Goran; Tjonneland, Anne; Agudo, Antonio; Benetou, Vassiliki; Bingham, Sheila; Boeing, Heiner; Boutron-Ruault, Marie-Christine and Bueno-de-Mesquita, H. Bas, et al. (2008) In Journal of Agricultural and Food Chemistry 56(15). p.6046-6053
Abstract
Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed including body mass index (BMI), educational level, and physical activity. A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts differed significantly by country, sex, and smoking status. HbGA... (More)
Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed including body mass index (BMI), educational level, and physical activity. A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts differed significantly by country, sex, and smoking status. HbGA values were significantly lower in high alcohol consumers than in moderate consumers. With increasing BMI, HbGA in nonsmokers and HbAA in smokers decreased significantly. In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered. (Less)
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publication status
published
subject
keywords
smoking, Cancer, European Prospective Investigation into, acrylamide, glycidamide, alcohol consumption, gender
in
Journal of Agricultural and Food Chemistry
volume
56
issue
15
pages
6046 - 6053
publisher
The American Chemical Society
external identifiers
  • wos:000258270300011
  • scopus:50449095240
ISSN
0021-8561
DOI
10.1021/jf703750t
language
English
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yes
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bc7fe662-2571-4849-ab2e-a293a2b3461c (old id 1253396)
date added to LUP
2008-11-17 14:27:40
date last changed
2017-07-09 03:47:17
@article{bc7fe662-2571-4849-ab2e-a293a2b3461c,
  abstract     = {Acrylamide exposure was investigated in subgroups of the EPIC study population (510 subjects from 9 European countries, randomly selected and stratified by age, gender, and smoking status) using hemoglobin adducts of acrylamide (HbAA) and its primary metabolite glycidamide (HbGA). Blood samples were analyzed for HbAA and HbGA by HPLC/MS/MS. Statistical models for HbAA and HbGA were developed including body mass index (BMI), educational level, and physical activity. A large variability in acrylamide exposure and metabolism between individuals and country groups was observed with HbAA and HbGA values ranging between 15-623 and 8-377 pmol/g of Hb, respectively. Both adducts differed significantly by country, sex, and smoking status. HbGA values were significantly lower in high alcohol consumers than in moderate consumers. With increasing BMI, HbGA in nonsmokers and HbAA in smokers decreased significantly. In the assessment of potential health effects related to acrylamide exposure, country of origin, BMI, alcohol consumption, sex, and smoking status should be considered.},
  author       = {Vesper, Hubert W. and Slimani, Nadia and Hallmans, Goran and Tjonneland, Anne and Agudo, Antonio and Benetou, Vassiliki and Bingham, Sheila and Boeing, Heiner and Boutron-Ruault, Marie-Christine and Bueno-de-Mesquita, H. Bas and Chirlaque, Dolores and Clavel-Chapelon, Francoise and Crowe, Francesca and Drogan, Dagmar and Ferrari, Pietro and Johansson, Ingegerd and Kaaks, Rudolf and Linseisen, Jakob and Lund, Eiliv and Manjer, Jonas and Mattiello, Amalia and Palli, Domenico and Peeters, Petra H. M. and Rinaldi, Sabina and Skeie, Guri and Trichopoulou, Antonia and Vineis, Paolo and Wirfält, Elisabet and Overvad, Kim and Strömberg, Ulf},
  issn         = {0021-8561},
  keyword      = {smoking,Cancer,European Prospective Investigation into,acrylamide,glycidamide,alcohol consumption,gender},
  language     = {eng},
  number       = {15},
  pages        = {6046--6053},
  publisher    = {The American Chemical Society},
  series       = {Journal of Agricultural and Food Chemistry},
  title        = {Cross-sectional study on acrylamide hemoglobin adducts in subpopulations from the European Prospective Investigation into Cancer and Nutrition (EPIC) study},
  url          = {http://dx.doi.org/10.1021/jf703750t},
  volume       = {56},
  year         = {2008},
}