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Effect of ileal infusion of short-chain fatty acids on pancreatic prandial secretion and gastrointestinal hormones in pigs

Sileikiene, Vaida; Mosenthin, Rainer; Bauer, Eva; Piepho, Hans-Peter; Tafaj, Myqerem; Kruszewska, Danuta LU ; Weström, Björn LU ; Erlanson-Albertsson, Charlotte LU and Pierzynowski, Stefan LU (2008) In Pancreas 37(2). p.196-202
Abstract
Objectives: Nutrients passing the ileum induce mechanisms regulating pancreatic secretion, but the effect of short-chain fatty acids (SCFAs) present in the ileum because of either intestinal fermentation or due to the cecoileal reflux is still unclear. This study investigated the effect of ileal SCFAs on pancreatic secretion and plasma levels of peptide YY, cholecystokinin, motilin, and neurotensin. Methods: The pigs were fitted with pancreatic duct, ileal, and jugular vein catheters, and a duodenal T-shaped cannula. Saline, 85.0 or 170.0 mM acetate, 5.0 or 10.0 mM butyrate, 7.5 or 15.0 mM propionate were infused into the ileum during feeding. Results: The ileal infusions of SCFAs did not affect the pancreatic juice outflow and the lipase... (More)
Objectives: Nutrients passing the ileum induce mechanisms regulating pancreatic secretion, but the effect of short-chain fatty acids (SCFAs) present in the ileum because of either intestinal fermentation or due to the cecoileal reflux is still unclear. This study investigated the effect of ileal SCFAs on pancreatic secretion and plasma levels of peptide YY, cholecystokinin, motilin, and neurotensin. Methods: The pigs were fitted with pancreatic duct, ileal, and jugular vein catheters, and a duodenal T-shaped cannula. Saline, 85.0 or 170.0 mM acetate, 5.0 or 10.0 mM butyrate, 7.5 or 15.0 mM propionate were infused into the ileum during feeding. Results: The ileal infusions of SCFAs did not affect the pancreatic juice outflow and the lipase output. The protein output was lower when 10.0 mM butyrate or 170.0 mM acetate were infused. The trypsin output decreased for most of the SCFA infusions. The alpha-amylase output decreased for the infusion of 10.0 mM butyrate and tended to decrease for 170.0 mM acetate. The infusions did not change gut hormone level. Conclusions: Ileal SCFAs might induce an inhibition of pancreatic enzyme secretion under prandial conditions. Ileal SCFAs do not inhibit pancreatic secretion by a hormonal pathway involving the release of peptide YY, motilin, neurotensin, or cholecystokinin. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
pancreatic secretion, ileal brake, short-chain fatty acids
in
Pancreas
volume
37
issue
2
pages
196 - 202
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000258012600014
  • scopus:55949100544
ISSN
0885-3177
language
English
LU publication?
yes
id
bc2b6c9f-1a75-4283-8d44-c5ee6ac1ac28 (old id 1253624)
date added to LUP
2008-11-10 12:00:37
date last changed
2017-01-01 04:24:08
@article{bc2b6c9f-1a75-4283-8d44-c5ee6ac1ac28,
  abstract     = {Objectives: Nutrients passing the ileum induce mechanisms regulating pancreatic secretion, but the effect of short-chain fatty acids (SCFAs) present in the ileum because of either intestinal fermentation or due to the cecoileal reflux is still unclear. This study investigated the effect of ileal SCFAs on pancreatic secretion and plasma levels of peptide YY, cholecystokinin, motilin, and neurotensin. Methods: The pigs were fitted with pancreatic duct, ileal, and jugular vein catheters, and a duodenal T-shaped cannula. Saline, 85.0 or 170.0 mM acetate, 5.0 or 10.0 mM butyrate, 7.5 or 15.0 mM propionate were infused into the ileum during feeding. Results: The ileal infusions of SCFAs did not affect the pancreatic juice outflow and the lipase output. The protein output was lower when 10.0 mM butyrate or 170.0 mM acetate were infused. The trypsin output decreased for most of the SCFA infusions. The alpha-amylase output decreased for the infusion of 10.0 mM butyrate and tended to decrease for 170.0 mM acetate. The infusions did not change gut hormone level. Conclusions: Ileal SCFAs might induce an inhibition of pancreatic enzyme secretion under prandial conditions. Ileal SCFAs do not inhibit pancreatic secretion by a hormonal pathway involving the release of peptide YY, motilin, neurotensin, or cholecystokinin.},
  author       = {Sileikiene, Vaida and Mosenthin, Rainer and Bauer, Eva and Piepho, Hans-Peter and Tafaj, Myqerem and Kruszewska, Danuta and Weström, Björn and Erlanson-Albertsson, Charlotte and Pierzynowski, Stefan},
  issn         = {0885-3177},
  keyword      = {pancreatic secretion,ileal brake,short-chain fatty acids},
  language     = {eng},
  number       = {2},
  pages        = {196--202},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Pancreas},
  title        = {Effect of ileal infusion of short-chain fatty acids on pancreatic prandial secretion and gastrointestinal hormones in pigs},
  volume       = {37},
  year         = {2008},
}