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Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition

Sieri, Sabina; Krogh, Vittorio; Ferrari, Pietro; Berrino, Franco; Pala, Valeria; Thiebaut, Anne C. M.; Tjonneland, Anne; Olsen, Anja; Overvad, Kim and Jakobsen, Marianne Uhre, et al. (2008) In American Journal of Clinical Nutrition 88(5). p.1304-1312
Abstract
Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. Results: An... (More)
Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. Results: An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. Conclusions: Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy. Am J Clin Nutr 2008; 88: 1304-12. (Less)
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American Journal of Clinical Nutrition
volume
88
issue
5
pages
1304 - 1312
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000260770600019
  • scopus:55849096928
ISSN
1938-3207
DOI
10.3945/ajcn.2008.26090
language
English
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yes
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69ded9c9-3cd9-499b-bbd1-ac63e2fa9b9c (old id 1283995)
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2009-02-09 10:48:18
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2017-11-19 03:58:53
@article{69ded9c9-3cd9-499b-bbd1-ac63e2fa9b9c,
  abstract     = {Background: Epidemiologic studies have produced conflicting results with respect to an association of dietary fat with breast cancer. Objective: We aimed to investigate the association between fat consumption and breast cancer. Design: We prospectively investigated fat consumption in a large (n = 319 826), geographically and culturally heterogeneous cohort of European women enrolled in the European Prospective Investigation into Cancer and Nutrition who completed a dietary questionnaire. After a mean of 8.8 y of follow-up, 7119 women developed breast cancer. Cox proportional hazard models, stratified by age and center and adjusted for energy intake and confounders, were used to estimate hazard ratios (HRs) for breast cancer. Results: An association between high saturated fat intake and greater breast cancer risk was found [HR = 1.13 (95% CI: 1.00, 1.27; P for trend = 0.038) for the highest quintile of saturated fat intake compared with the lowest quintile: 1.02 (1.00, 1.04) for a 20% increase in saturated fat consumption (continuous variable)]. No significant association of breast cancer with total, monounsaturated, or polyunsaturated fat was found, although trends were for a direct association of risk with monounsaturated fat and an inverse association with polyunsaturated fat. In menopausal women, the positive association with saturated fat was confined to nonusers of hormone therapy at baseline [1.21 (0.99, 1.48) for the highest quintile compared with the lowest quintile; P for trend = 0.044; and 1.03 (1.00, 1.07) for a 20% increase in saturated fat as a continuous variable]. Conclusions: Evidence indicates a weak positive association between saturated fat intake and breast cancer risk. This association was more pronounced for postmenopausal women who never used hormone therapy. Am J Clin Nutr 2008; 88: 1304-12.},
  author       = {Sieri, Sabina and Krogh, Vittorio and Ferrari, Pietro and Berrino, Franco and Pala, Valeria and Thiebaut, Anne C. M. and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Jakobsen, Marianne Uhre and Clavel-Chapelon, Francoise and Chajes, Veronique and Boutron-Ruault, Marie-Christine and Kaaks, Rudolf and Linseisen, Jakob and Boeing, Heiner and Noethlings, Ute and Trichopoulou, Antonia and Naska, Androniki and Lagiou, Pagona and Panico, Salvatore and Palli, Domenico and Vineis, Paolo and Tumino, Rosario and Lund, Eiliv and Kumle, Merethe and Skeie, Guri and Gonzalez, Carlos A. and Ardanaz, Eva and Amiano, Pilar and Tormo, Maria Jose and Martinez-Garcia, Carmen and Quiros, Jose R. and Berglund, Göran and Gullberg, Bo and Hallmans, Goeran and Lenner, Per and Bueno-de-Mesquita, H. Bas and van Duijnhoven, Fraenzel J. B. and Peeters, Petra H. M. and van Gils, Carla H. and Key, Timothy J. and Crowe, Francesca L. and Bingham, Sheila and Khaw, Kay Tee and Rinaldi, Sabina and Slimani, Nadia and Jenab, Mazda and Norat, Teresa and Riboli, Elio},
  issn         = {1938-3207},
  language     = {eng},
  number       = {5},
  pages        = {1304--1312},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Dietary fat and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.3945/ajcn.2008.26090},
  volume       = {88},
  year         = {2008},
}