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The Protective Association of High Plasma Enterolactone with Breast Cancer Is Reasonably Robust in Women with Polymorphisms in the Estrogen Receptor alpha and beta Genes

Sonestedt, Emily LU ; Ivarsson, Malin I. L.; Harlid, Sophia LU ; Ericson, Ulrika LU ; Gullberg, Bo LU ; Carlson, Joyce LU ; Olsson, Hakan; Adlercreutz, Herman and Wirfält, Elisabet LU (2009) In Journal of Nutrition 139(5). p.993-1001
Abstract
It is plausible that polymorph isms in the estrogen receptor alpha and beta genes (ESR1 and ESR2) may modulate the association between enterolactone and breast cancer. Seven polymorph isms in ESR1 (rs827422, rs1709184, rs2347867, rs3020328, rs72207, rs2982896, and rs2234693) and 5 polymorphisms in ESR2 (rs915057, rs1269056, rs1256033, rs3020450, and rs3020443) were selected. The risk of breast cancer for these polymorphisms was estimated among 542 cases and 1076 matched controls from the population-based Malmo Diet and Cancer cohort. The joint effect of these polymorphisms and enterolactone was estimated among those individuals about whom we had information on enterolactone blood concentration (365 cases and 728 controls). Breast cancer... (More)
It is plausible that polymorph isms in the estrogen receptor alpha and beta genes (ESR1 and ESR2) may modulate the association between enterolactone and breast cancer. Seven polymorph isms in ESR1 (rs827422, rs1709184, rs2347867, rs3020328, rs72207, rs2982896, and rs2234693) and 5 polymorphisms in ESR2 (rs915057, rs1269056, rs1256033, rs3020450, and rs3020443) were selected. The risk of breast cancer for these polymorphisms was estimated among 542 cases and 1076 matched controls from the population-based Malmo Diet and Cancer cohort. The joint effect of these polymorphisms and enterolactone was estimated among those individuals about whom we had information on enterolactone blood concentration (365 cases and 728 controls). Breast cancer risk was not significantly associated with any of the selected polymorphisms. We found a tendency for an interaction between a polymorphism in intron 3 of ESR1 (rs2347867) and enterolactone concentration (P = 0.07). Breast cancer and enterolactone concentration were not associated among those homozygous for the major allele (A) (P = 0.93), whereas we found an inverse association among carriers of the minor allele (G) (P = 0.007). None of the other polymorphisms seem to modify the association between enterolactone and breast cancer. This study suggests that the protective association of enterolactone is reasonably robust across the investigated genotypes. The suggested interaction between enterolactone concentration and rs2347867 needs to be confirmed in larger samples. J. Nutr. 139: 993-1001, 2009. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nutrition
volume
139
issue
5
pages
993 - 1001
publisher
American Society for Nutrition
external identifiers
  • wos:000265424500027
  • scopus:65349156844
ISSN
1541-6100
DOI
10.3945/jn.108.101691
language
English
LU publication?
yes
id
8c46b44c-fc49-43d4-b903-3326bd8caccb (old id 1399481)
date added to LUP
2009-06-15 15:13:19
date last changed
2017-06-11 03:30:04
@article{8c46b44c-fc49-43d4-b903-3326bd8caccb,
  abstract     = {It is plausible that polymorph isms in the estrogen receptor alpha and beta genes (ESR1 and ESR2) may modulate the association between enterolactone and breast cancer. Seven polymorph isms in ESR1 (rs827422, rs1709184, rs2347867, rs3020328, rs72207, rs2982896, and rs2234693) and 5 polymorphisms in ESR2 (rs915057, rs1269056, rs1256033, rs3020450, and rs3020443) were selected. The risk of breast cancer for these polymorphisms was estimated among 542 cases and 1076 matched controls from the population-based Malmo Diet and Cancer cohort. The joint effect of these polymorphisms and enterolactone was estimated among those individuals about whom we had information on enterolactone blood concentration (365 cases and 728 controls). Breast cancer risk was not significantly associated with any of the selected polymorphisms. We found a tendency for an interaction between a polymorphism in intron 3 of ESR1 (rs2347867) and enterolactone concentration (P = 0.07). Breast cancer and enterolactone concentration were not associated among those homozygous for the major allele (A) (P = 0.93), whereas we found an inverse association among carriers of the minor allele (G) (P = 0.007). None of the other polymorphisms seem to modify the association between enterolactone and breast cancer. This study suggests that the protective association of enterolactone is reasonably robust across the investigated genotypes. The suggested interaction between enterolactone concentration and rs2347867 needs to be confirmed in larger samples. J. Nutr. 139: 993-1001, 2009.},
  author       = {Sonestedt, Emily and Ivarsson, Malin I. L. and Harlid, Sophia and Ericson, Ulrika and Gullberg, Bo and Carlson, Joyce and Olsson, Hakan and Adlercreutz, Herman and Wirfält, Elisabet},
  issn         = {1541-6100},
  language     = {eng},
  number       = {5},
  pages        = {993--1001},
  publisher    = {American Society for Nutrition},
  series       = {Journal of Nutrition},
  title        = {The Protective Association of High Plasma Enterolactone with Breast Cancer Is Reasonably Robust in Women with Polymorphisms in the Estrogen Receptor alpha and beta Genes},
  url          = {http://dx.doi.org/10.3945/jn.108.101691},
  volume       = {139},
  year         = {2009},
}