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Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Nagel, G.; Linseisen, J.; van Gils, C. H.; Peeters, P. H.; Boutron-Ruault, M. C.; Clavel-Chapelon, F.; Romieu, I.; Tjonneland, A.; Olsen, A. and Roswall, N., et al. (2010) In Breast Cancer Research and Treatment 119(3). p.753-765
Abstract
So far, studies on dietary antioxidant intake, including beta-carotene, vitamin C and vitamin E, and breast cancer risk are inconclusive. Thus, we addressed this question in the European Prospective Investigation into Cancer and Nutrition. During a median follow-up time of 8.8 years, 7,502 primary invasive breast cancer cases were identified. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). All analyses were run stratified by menopausal status at recruitment and, additionally, by smoking status, alcohol intake, use of exogenous hormones and use of dietary supplements. In the multivariate analyses, dietary intake of beta-carotene, vitamin C and E was not associated with breast cancer... (More)
So far, studies on dietary antioxidant intake, including beta-carotene, vitamin C and vitamin E, and breast cancer risk are inconclusive. Thus, we addressed this question in the European Prospective Investigation into Cancer and Nutrition. During a median follow-up time of 8.8 years, 7,502 primary invasive breast cancer cases were identified. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). All analyses were run stratified by menopausal status at recruitment and, additionally, by smoking status, alcohol intake, use of exogenous hormones and use of dietary supplements. In the multivariate analyses, dietary intake of beta-carotene, vitamin C and E was not associated with breast cancer risk in premenopausal [highest vs. lowest quintile: HR, 1.04 (95% CI, 0.85-1.27), 1.12 (0.92-1.36) and 1.11 (0.84-1.46), respectively] and postmenopausal women [0.93 (0.82-1.04), 0.98 (0.87-1.11) and 0.92 (0.77-1.11), respectively]. However, in postmenopausal women using exogenous hormones, high intake of beta-carotene [highest vs. lowest quintile; HR 0.79 (95% CI, 0.66-0.96), P (trend) 0.06] and vitamin C [0.88 (0.72-1.07), P (trend) 0.05] was associated with reduced breast cancer risk. In addition, dietary beta-carotene was associated with a decreased risk in postmenopausal women with high alcohol intake. Overall, dietary intake of beta-carotene, vitamin C and E was not related to breast cancer risk in neither pre- nor postmenopausal women. However, in subgroups of postmenopausal women, a weak protective effect between beta-carotene and vitamin E from food and breast cancer risk cannot be excluded. (Less)
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subject
keywords
Breast cancer, Vitamin E, beta-Carotene, Vitamin C, Diet, EPIC
in
Breast Cancer Research and Treatment
volume
119
issue
3
pages
753 - 765
publisher
Springer
external identifiers
  • wos:000273624900024
  • scopus:74849089616
ISSN
1573-7217
DOI
10.1007/s10549-009-0444-8
language
English
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yes
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1b298fd7-8267-42c5-a699-fc50e050898e (old id 1547636)
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2010-02-23 13:35:47
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2018-05-29 09:40:28
@article{1b298fd7-8267-42c5-a699-fc50e050898e,
  abstract     = {So far, studies on dietary antioxidant intake, including beta-carotene, vitamin C and vitamin E, and breast cancer risk are inconclusive. Thus, we addressed this question in the European Prospective Investigation into Cancer and Nutrition. During a median follow-up time of 8.8 years, 7,502 primary invasive breast cancer cases were identified. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). All analyses were run stratified by menopausal status at recruitment and, additionally, by smoking status, alcohol intake, use of exogenous hormones and use of dietary supplements. In the multivariate analyses, dietary intake of beta-carotene, vitamin C and E was not associated with breast cancer risk in premenopausal [highest vs. lowest quintile: HR, 1.04 (95% CI, 0.85-1.27), 1.12 (0.92-1.36) and 1.11 (0.84-1.46), respectively] and postmenopausal women [0.93 (0.82-1.04), 0.98 (0.87-1.11) and 0.92 (0.77-1.11), respectively]. However, in postmenopausal women using exogenous hormones, high intake of beta-carotene [highest vs. lowest quintile; HR 0.79 (95% CI, 0.66-0.96), P (trend) 0.06] and vitamin C [0.88 (0.72-1.07), P (trend) 0.05] was associated with reduced breast cancer risk. In addition, dietary beta-carotene was associated with a decreased risk in postmenopausal women with high alcohol intake. Overall, dietary intake of beta-carotene, vitamin C and E was not related to breast cancer risk in neither pre- nor postmenopausal women. However, in subgroups of postmenopausal women, a weak protective effect between beta-carotene and vitamin E from food and breast cancer risk cannot be excluded.},
  author       = {Nagel, G. and Linseisen, J. and van Gils, C. H. and Peeters, P. H. and Boutron-Ruault, M. C. and Clavel-Chapelon, F. and Romieu, I. and Tjonneland, A. and Olsen, A. and Roswall, N. and Witt, P. M. and Overvad, K. and Rohrmann, S. and Kaaks, R. and Drogan, D. and Boeing, H. and Trichopoulou, A. and Stratigakou, V. and Zylis, D. and Engeset, D. and Lund, E. and Skeie, G. and Berrino, F. and Grioni, S. and Mattiello, A. and Masala, G. and Tumino, R. and Zanetti, R. and Ros, M. M. and Bueno-de-Mesquita, H. B. and Ardanaz, E. and Sanchez, M. J. and Huerta, J. M. and Amiano, P. and Rodriguez, L. and Manjer, Jonas and Wirfält, Elisabet and Lenner, P. and Hallmans, G. and Spencer, E. A. and Key, T. J. and Bingham, S. and Khaw, K. T. and Rinaldi, S. and Slimani, N. and Boffetta, P. and Gallo, V. and Norat, T. and Riboli, E.},
  issn         = {1573-7217},
  keyword      = {Breast cancer,Vitamin E,beta-Carotene,Vitamin C,Diet,EPIC},
  language     = {eng},
  number       = {3},
  pages        = {753--765},
  publisher    = {Springer},
  series       = {Breast Cancer Research and Treatment},
  title        = {Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1007/s10549-009-0444-8},
  volume       = {119},
  year         = {2010},
}