A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice.
(2010) In Diabetes, Obesity and Metabolism 12(11). p.976-982- Abstract
- AIM: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model. METHODS: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance tests were performed to investigate the effect of the experimental diets on glucose tolerance and insulin resistance. RESULTS: In this study, a high glycaemic diet resulted in impaired oral glucose tolerance compared to a low glycaemic diet. This effect was more pronounced in the group fed a medium-fat diet, suggesting that a lower dietary fat... (More)
- AIM: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model. METHODS: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance tests were performed to investigate the effect of the experimental diets on glucose tolerance and insulin resistance. RESULTS: In this study, a high glycaemic diet resulted in impaired oral glucose tolerance compared to a low glycaemic diet. This effect was more pronounced in the group fed a medium-fat diet, suggesting that a lower dietary fat content ameliorates the negative effect of a high glycaemic diet. No effect on body weight or body fat content was observed in either a low-fat diet or a medium-fat diet. Static incubation of isolated islets did not show any differences in basal (3.3 mM glucose) or glucose-stimulated (8.6 and 16.7 mM glucose) insulin secretion between mice fed a low or high glycaemic diet. CONCLUSION: Together, our data suggest that the impaired glucose tolerance seen after a high glycaemic diet is not explained by altered β-cell function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1711613
- author
- Axling, Ulrika LU ; Rosén, Liza LU ; Wierup, Nils LU ; Östman, Elin LU ; Björck, Inger LU and Holm, Cecilia LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- body composition, beta-cell, glycaemic control
- in
- Diabetes, Obesity and Metabolism
- volume
- 12
- issue
- 11
- pages
- 976 - 982
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000282377100006
- pmid:20880344
- scopus:77957272603
- pmid:20880344
- ISSN
- 1462-8902
- DOI
- 10.1111/j.1463-1326.2010.01288.x
- project
- ANTIDIABETIC FOOD CENTRE
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Molecular Endocrinology (013212018), Applied Nutrition and Food Chemistry (011001300)
- id
- 249fb951-2ac0-4ed2-899a-b83aeabf8c07 (old id 1711613)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20880344?dopt=Abstract
- date added to LUP
- 2016-04-01 10:53:45
- date last changed
- 2023-09-28 16:50:05
@article{249fb951-2ac0-4ed2-899a-b83aeabf8c07, abstract = {{AIM: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model. METHODS: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance tests were performed to investigate the effect of the experimental diets on glucose tolerance and insulin resistance. RESULTS: In this study, a high glycaemic diet resulted in impaired oral glucose tolerance compared to a low glycaemic diet. This effect was more pronounced in the group fed a medium-fat diet, suggesting that a lower dietary fat content ameliorates the negative effect of a high glycaemic diet. No effect on body weight or body fat content was observed in either a low-fat diet or a medium-fat diet. Static incubation of isolated islets did not show any differences in basal (3.3 mM glucose) or glucose-stimulated (8.6 and 16.7 mM glucose) insulin secretion between mice fed a low or high glycaemic diet. CONCLUSION: Together, our data suggest that the impaired glucose tolerance seen after a high glycaemic diet is not explained by altered β-cell function.}}, author = {{Axling, Ulrika and Rosén, Liza and Wierup, Nils and Östman, Elin and Björck, Inger and Holm, Cecilia}}, issn = {{1462-8902}}, keywords = {{body composition; beta-cell; glycaemic control}}, language = {{eng}}, number = {{11}}, pages = {{976--982}}, publisher = {{Wiley-Blackwell}}, series = {{Diabetes, Obesity and Metabolism}}, title = {{A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice.}}, url = {{http://dx.doi.org/10.1111/j.1463-1326.2010.01288.x}}, doi = {{10.1111/j.1463-1326.2010.01288.x}}, volume = {{12}}, year = {{2010}}, }