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Plasma Vitamins B2, B6, and B12, and Related Genetic Variants as Predictors of Colorectal Cancer Risk

Eussen, Simone J. P. M.; Vollset, Stein Emil; Hustad, Steinar; Midttun, Oivind; Meyer, Klaus; Fredriksen, Ase; Ueland, Per Magne; Jenab, Mazda; Slimani, Nadia and Boffetta, Paolo, et al. (2010) In Cancer Epidemiology Biomarkers & Prevention 19(10). p.2549-2561
Abstract
Background: B-vitamins are essential for one-carbon metabolism and have been linked to colorectal cancer. Although associations with folate have frequently been studied, studies on other plasma vitamins B2, B6, and B12 and colorectal cancer are scarce or inconclusive. Methods: We carried out a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, including 1,365 incident colorectal cancer cases and 2,319 controls matched for study center, age, and sex. We measured the sum of B2 species riboflavin and flavin mononucleotide, and the sum of B6 species pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples... (More)
Background: B-vitamins are essential for one-carbon metabolism and have been linked to colorectal cancer. Although associations with folate have frequently been studied, studies on other plasma vitamins B2, B6, and B12 and colorectal cancer are scarce or inconclusive. Methods: We carried out a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, including 1,365 incident colorectal cancer cases and 2,319 controls matched for study center, age, and sex. We measured the sum of B2 species riboflavin and flavin mononucleotide, and the sum of B6 species pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples collected at baseline. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for colorectal cancer were estimated using conditional logistic regression, adjusted for smoking, education, physical activity, body mass index, alcohol consumption, and intakes of fiber and red and processed meat. Results: The relative risks comparing highest to lowest quintile were 0.71 [95% confidence interval (95% CI), 0.56-0.91; P-trend = 0.02] for vitamin B2, 0.68 (95% CI, 0.53-0.87; P-trend <0.001) for vitamin B6, and 1.02 (95% CI, 0.80-1.29; P-trend = 0.19) for vitamin B12. The associations for vitamin B6 were stronger in males who consumed >= 30 g alcohol/day. The polymorphisms were not associated with colorectal cancer. Conclusions: Higher plasma concentrations of vitamins B2 and B6 are associated with a lower colorectal cancer risk. Impact: This European population-based study is the first to indicate that vitamin B2 is inversely associated with colorectal cancer, and is in agreement with previously suggested inverse associations of vitamin B6 with colorectal cancer. Cancer Epidemiol Biomarkers Prev; 19(10); 2549-61. (C) 2010 AACR. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
19
issue
10
pages
2549 - 2561
publisher
American Association for Cancer Research
external identifiers
  • wos:000282590500017
  • scopus:77958044542
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-10-0407
language
English
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yes
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e01a28dc-41be-4461-b794-223a7b666f3a (old id 1727997)
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2010-11-23 09:12:35
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@article{e01a28dc-41be-4461-b794-223a7b666f3a,
  abstract     = {Background: B-vitamins are essential for one-carbon metabolism and have been linked to colorectal cancer. Although associations with folate have frequently been studied, studies on other plasma vitamins B2, B6, and B12 and colorectal cancer are scarce or inconclusive. Methods: We carried out a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, including 1,365 incident colorectal cancer cases and 2,319 controls matched for study center, age, and sex. We measured the sum of B2 species riboflavin and flavin mononucleotide, and the sum of B6 species pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid as indicators for vitamin B2 and B6 status, as well as vitamin B12 in plasma samples collected at baseline. In addition, we determined eight polymorphisms related to one-carbon metabolism. Relative risks for colorectal cancer were estimated using conditional logistic regression, adjusted for smoking, education, physical activity, body mass index, alcohol consumption, and intakes of fiber and red and processed meat. Results: The relative risks comparing highest to lowest quintile were 0.71 [95% confidence interval (95% CI), 0.56-0.91; P-trend = 0.02] for vitamin B2, 0.68 (95% CI, 0.53-0.87; P-trend &lt;0.001) for vitamin B6, and 1.02 (95% CI, 0.80-1.29; P-trend = 0.19) for vitamin B12. The associations for vitamin B6 were stronger in males who consumed &gt;= 30 g alcohol/day. The polymorphisms were not associated with colorectal cancer. Conclusions: Higher plasma concentrations of vitamins B2 and B6 are associated with a lower colorectal cancer risk. Impact: This European population-based study is the first to indicate that vitamin B2 is inversely associated with colorectal cancer, and is in agreement with previously suggested inverse associations of vitamin B6 with colorectal cancer. Cancer Epidemiol Biomarkers Prev; 19(10); 2549-61. (C) 2010 AACR.},
  author       = {Eussen, Simone J. P. M. and Vollset, Stein Emil and Hustad, Steinar and Midttun, Oivind and Meyer, Klaus and Fredriksen, Ase and Ueland, Per Magne and Jenab, Mazda and Slimani, Nadia and Boffetta, Paolo and Overvad, Kim and Thorlacius-Ussing, Ole and Tjonneland, Anne and Olsen, Anja and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Morois, Sophie and Weikert, Cornelia and Pischon, Tobias and Linseisen, Jakob and Kaaks, Rudolf and Trichopoulou, Antonia and Zilis, Demosthenes and Katsoulis, Michael and Palli, Domenico and Pala, Valeria and Vineis, Paolo and Tumino, Rosario and Panico, Salvatore and Peeters, Petra H. M. and Bueno-de-Mesquita, H. Bas and van Duijnhoven, Franzel J. B. and Skeie, Guri and Munoz, Xavier and Martinez, Carmen and Dorronsoro, Miren and Ardanaz, Eva and Navarro, Carmen and Rodriguez, Laudina and VanGuelpen, Bethany and Palmqvist, Richard and Manjer, Jonas and Ericson, Ulrika and Bingham, Sheila and Khaw, Kay-Tee and Norat, Teresa and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  number       = {10},
  pages        = {2549--2561},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Plasma Vitamins B2, B6, and B12, and Related Genetic Variants as Predictors of Colorectal Cancer Risk},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-10-0407},
  volume       = {19},
  year         = {2010},
}