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Reduced neurogenesis in the rat hippocampus following high fructose consumption.

Van der Borght, Karin; Köhnke, Rickard LU ; Göransson, Nathanael; Deierborg, Tomas LU ; Brundin, Patrik LU ; Erlanson-Albertsson, Charlotte LU and Lindqvist, Andreas LU (2011) In Regulatory Peptides 167. p.26-30
Abstract
In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study add to the list of harmful effects associated with... (More)
In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study add to the list of harmful effects associated with prolonged and excessive consumption of sugary beverages and soft drinks. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Regulatory Peptides
volume
167
pages
26 - 30
publisher
Elsevier
external identifiers
  • wos:000288774900006
  • pmid:21115071
  • scopus:79951671434
ISSN
1873-1686
DOI
10.1016/j.regpep.2010.11.002
language
English
LU publication?
yes
id
8cc76f3a-3d55-4dcc-87b9-16167c7536c0 (old id 1756982)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21115071?dopt=Abstract
date added to LUP
2011-01-03 09:49:08
date last changed
2017-09-24 04:37:40
@article{8cc76f3a-3d55-4dcc-87b9-16167c7536c0,
  abstract     = {In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study add to the list of harmful effects associated with prolonged and excessive consumption of sugary beverages and soft drinks.},
  author       = {Van der Borght, Karin and Köhnke, Rickard and Göransson, Nathanael and Deierborg, Tomas and Brundin, Patrik and Erlanson-Albertsson, Charlotte and Lindqvist, Andreas},
  issn         = {1873-1686},
  language     = {eng},
  pages        = {26--30},
  publisher    = {Elsevier},
  series       = {Regulatory Peptides},
  title        = {Reduced neurogenesis in the rat hippocampus following high fructose consumption.},
  url          = {http://dx.doi.org/10.1016/j.regpep.2010.11.002},
  volume       = {167},
  year         = {2011},
}