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Mediterranean dietary pattern and cancer risk in the EPIC cohort

Couto, E.; Boffetta, P.; Lagiou, P.; Ferrari, P.; Buckland, G.; Overvad, K.; Dahm, C. C.; Tjonneland, A.; Olsen, A. and Clavel-Chapelon, F., et al. (2011) In British Journal of Cancer 104(9). p.1493-1499
Abstract
BACKGROUND: Although several studies have investigated the association of the Mediterranean diet with overall mortality or risk of specific cancers, data on overall cancer risk are sparse. METHODS: We examined the association between adherence to Mediterranean dietary pattern and overall cancer risk using data from the European Prospective Investigation Into Cancer and nutrition, a multi-centre prospective cohort study including 142 605 men and 335 873. Adherence to Mediterranean diet was examined using a score (range: 0-9) considering the combined intake of fruits and nuts, vegetables, legumes, cereals, lipids, fish, dairy products, meat products, and alcohol. Association with cancer incidence was assessed through Cox regression... (More)
BACKGROUND: Although several studies have investigated the association of the Mediterranean diet with overall mortality or risk of specific cancers, data on overall cancer risk are sparse. METHODS: We examined the association between adherence to Mediterranean dietary pattern and overall cancer risk using data from the European Prospective Investigation Into Cancer and nutrition, a multi-centre prospective cohort study including 142 605 men and 335 873. Adherence to Mediterranean diet was examined using a score (range: 0-9) considering the combined intake of fruits and nuts, vegetables, legumes, cereals, lipids, fish, dairy products, meat products, and alcohol. Association with cancer incidence was assessed through Cox regression modelling, controlling for potential confounders. RESULTS: In all, 9669 incident cancers in men and 21 062 in women were identified. A lower overall cancer risk was found among individuals with greater adherence to Mediterranean diet (hazard ratio = 0.96, 95% CI 0.95-0.98) for a two-point increment of the Mediterranean diet score. The apparent inverse association was stronger for smoking-related cancers than for cancers not known to be related to tobacco (P (heterogeneity) = 0.008). In all, 4.7% of cancers among men and 2.4% in women would be avoided in this population if study subjects had a greater adherence to Mediterranean dietary pattern. CONCLUSION: Greater adherence to a Mediterranean dietary pattern could reduce overall cancer risk. British Journal of Cancer (2011) 104, 1493-1499. doi:10.1038/bjc.2011.106 www.bjcancer.com Published online 5 April 2011 (C) 2011 Cancer Research UK (Less)
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publication status
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keywords
* dietary patterns * Mediterranean diet * cancer risk * epidemiology
in
British Journal of Cancer
volume
104
issue
9
pages
1493 - 1499
publisher
Nature Publishing Group
external identifiers
  • wos:000289934900018
  • scopus:79955475915
ISSN
1532-1827
DOI
10.1038/bjc.2011.106
language
English
LU publication?
yes
id
b5d9565c-4753-45f9-97ba-7919cf865f30 (old id 1964534)
date added to LUP
2011-05-23 15:37:01
date last changed
2017-10-22 03:21:35
@article{b5d9565c-4753-45f9-97ba-7919cf865f30,
  abstract     = {BACKGROUND: Although several studies have investigated the association of the Mediterranean diet with overall mortality or risk of specific cancers, data on overall cancer risk are sparse. METHODS: We examined the association between adherence to Mediterranean dietary pattern and overall cancer risk using data from the European Prospective Investigation Into Cancer and nutrition, a multi-centre prospective cohort study including 142 605 men and 335 873. Adherence to Mediterranean diet was examined using a score (range: 0-9) considering the combined intake of fruits and nuts, vegetables, legumes, cereals, lipids, fish, dairy products, meat products, and alcohol. Association with cancer incidence was assessed through Cox regression modelling, controlling for potential confounders. RESULTS: In all, 9669 incident cancers in men and 21 062 in women were identified. A lower overall cancer risk was found among individuals with greater adherence to Mediterranean diet (hazard ratio = 0.96, 95% CI 0.95-0.98) for a two-point increment of the Mediterranean diet score. The apparent inverse association was stronger for smoking-related cancers than for cancers not known to be related to tobacco (P (heterogeneity) = 0.008). In all, 4.7% of cancers among men and 2.4% in women would be avoided in this population if study subjects had a greater adherence to Mediterranean dietary pattern. CONCLUSION: Greater adherence to a Mediterranean dietary pattern could reduce overall cancer risk. British Journal of Cancer (2011) 104, 1493-1499. doi:10.1038/bjc.2011.106 www.bjcancer.com Published online 5 April 2011 (C) 2011 Cancer Research UK},
  author       = {Couto, E. and Boffetta, P. and Lagiou, P. and Ferrari, P. and Buckland, G. and Overvad, K. and Dahm, C. C. and Tjonneland, A. and Olsen, A. and Clavel-Chapelon, F. and Boutron-Ruault, M-C and Cottet, V. and Trichopoulos, D. and Naska, A. and Benetou, V. and Kaaks, R. and Rohrmann, S. and Boeing, H. and von Ruesten, A. and Panico, S. and Pala, V. and Vineis, P. and Palli, D. and Tumino, R. and May, A. and Peeters, P. H. and Bueno-de-Mesquita, H. B. and Buchner, F. L. and Lund, E. and Skeie, G. and Engeset, D. and Gonzalez, C. A. and Navarro, C. and Rodriguez, L. and Sanchez, M-J and Amiano, P. and Barricarte, A. and Hallmans, G. and Johansson, I. and Manjer, Jonas and Wirfält, Elisabet and Allen, N. E. and Crowe, F. and Khaw, K-T and Wareham, N. and Moskal, A. and Slimani, N. and Jenab, M. and Romaguera, D. and Mouw, T. and Norat, T. and Riboli, E. and Trichopoulou, A.},
  issn         = {1532-1827},
  keyword      = {* dietary patterns
* Mediterranean diet
* cancer risk
* epidemiology},
  language     = {eng},
  number       = {9},
  pages        = {1493--1499},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Mediterranean dietary pattern and cancer risk in the EPIC cohort},
  url          = {http://dx.doi.org/10.1038/bjc.2011.106},
  volume       = {104},
  year         = {2011},
}