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Diffusion tensor imaging in glioblastoma patients treated with volumetric modulated arc radiotherapy : a longitudinal study

Rydelius, Anna LU ; Lampinen, Björn LU ; Rundcrantz, Andreas ; Bengzon, Johan LU ; Engelholm, Silke ; van Westen, Danielle LU orcid ; Kinhult, Sara LU ; Knutsson, Linda LU orcid ; Lätt, Jimmy LU and Nilsson, Markus LU , et al. (2022) In Acta oncologica (Stockholm, Sweden) 61(6). p.680-687
Abstract

BACKGROUND: Chemo- and radiotherapy (RT) is standard treatment for patients with high-grade glioma, but may cause side-effects on the patient's cognitive function.

AIM: Use of diffusion tensor imaging (DTI) to investigate the longitudinal changes in normal-appearing brain tissue in glioblastoma patients undergoing modern arc-based RT with volumetric modulated arc therapy (VMAT) or helical tomotherapy.

MATERIALS AND METHODS: The study included 27 patients newly diagnosed with glioblastoma and planned for VMAT or tomotherapy. All subjects underwent magnetic resonance imaging at the start of RT and at week 3, 6, 15, and 26. Fourteen subjects were additionally imaged at week 52. The DTI data were co-registered to the dose... (More)

BACKGROUND: Chemo- and radiotherapy (RT) is standard treatment for patients with high-grade glioma, but may cause side-effects on the patient's cognitive function.

AIM: Use of diffusion tensor imaging (DTI) to investigate the longitudinal changes in normal-appearing brain tissue in glioblastoma patients undergoing modern arc-based RT with volumetric modulated arc therapy (VMAT) or helical tomotherapy.

MATERIALS AND METHODS: The study included 27 patients newly diagnosed with glioblastoma and planned for VMAT or tomotherapy. All subjects underwent magnetic resonance imaging at the start of RT and at week 3, 6, 15, and 26. Fourteen subjects were additionally imaged at week 52. The DTI data were co-registered to the dose distribution maps. Longitudinal changes in fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were assessed in the corpus callosum, the centrum semiovale, the hippocampus, and the amygdala.

RESULTS: Significant longitudinal changes in FA, MD, and RD were mainly found in the corpus callosum. In the other examined brain structures, only sparse and transient changes were seen. No consistent correlations were found between biodose, age, or gender and changes in DTI parameters.

CONCLUSION: Longitudinal changes in MD, FA, and RD were observed but only in a limited number of brain structures and the changes were smaller than expected from literature. The results suggest that modern, arc-based RT may have less negative effect on normal-appearing parts of the brain tissue up to 12 months after radiotherapy.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta oncologica (Stockholm, Sweden)
volume
61
issue
6
pages
680 - 687
publisher
Taylor & Francis
external identifiers
  • scopus:85126446211
  • pmid:35275512
ISSN
1651-226X
DOI
10.1080/0284186X.2022.2045036
language
English
LU publication?
yes
id
1d8316ed-3d4e-49df-a523-ca54d36f933d
date added to LUP
2022-03-12 18:43:18
date last changed
2024-06-16 07:02:12
@article{1d8316ed-3d4e-49df-a523-ca54d36f933d,
  abstract     = {{<p>BACKGROUND: Chemo- and radiotherapy (RT) is standard treatment for patients with high-grade glioma, but may cause side-effects on the patient's cognitive function.</p><p>AIM: Use of diffusion tensor imaging (DTI) to investigate the longitudinal changes in normal-appearing brain tissue in glioblastoma patients undergoing modern arc-based RT with volumetric modulated arc therapy (VMAT) or helical tomotherapy.</p><p>MATERIALS AND METHODS: The study included 27 patients newly diagnosed with glioblastoma and planned for VMAT or tomotherapy. All subjects underwent magnetic resonance imaging at the start of RT and at week 3, 6, 15, and 26. Fourteen subjects were additionally imaged at week 52. The DTI data were co-registered to the dose distribution maps. Longitudinal changes in fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were assessed in the corpus callosum, the centrum semiovale, the hippocampus, and the amygdala.</p><p>RESULTS: Significant longitudinal changes in FA, MD, and RD were mainly found in the corpus callosum. In the other examined brain structures, only sparse and transient changes were seen. No consistent correlations were found between biodose, age, or gender and changes in DTI parameters.</p><p>CONCLUSION: Longitudinal changes in MD, FA, and RD were observed but only in a limited number of brain structures and the changes were smaller than expected from literature. The results suggest that modern, arc-based RT may have less negative effect on normal-appearing parts of the brain tissue up to 12 months after radiotherapy.</p>}},
  author       = {{Rydelius, Anna and Lampinen, Björn and Rundcrantz, Andreas and Bengzon, Johan and Engelholm, Silke and van Westen, Danielle and Kinhult, Sara and Knutsson, Linda and Lätt, Jimmy and Nilsson, Markus and Sundgren, Pia C}},
  issn         = {{1651-226X}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{6}},
  pages        = {{680--687}},
  publisher    = {{Taylor & Francis}},
  series       = {{Acta oncologica (Stockholm, Sweden)}},
  title        = {{Diffusion tensor imaging in glioblastoma patients treated with volumetric modulated arc radiotherapy : a longitudinal study}},
  url          = {{http://dx.doi.org/10.1080/0284186X.2022.2045036}},
  doi          = {{10.1080/0284186X.2022.2045036}},
  volume       = {{61}},
  year         = {{2022}},
}