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Food sources of fat and sex hormone receptor status of invasive breast tumors in women of the malmö diet and cancer cohort.

Wirfält, Elisabet LU ; Li, Cairu LU ; Manjer, Jonas LU ; Ericson, Ulrika LU ; Sonestedt, Emily LU ; Borgquist, Signe LU ; Landberg, Göran LU ; Olsson, Håkan LU and Gullberg, Bo LU (2011) In Nutrition and Cancer 63(5). p.722-733
Abstract
We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmö Diet and Cancer cohort (17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR+ tumors, a protective linear risk trend, indicating change between adjoining food categories, was seen with yogurt (HR = 0.89, 95% CI = 0.80-0.99), but increased risks with eggs (HR = 1.10, 95% CI = 1.01-1.20) and dried soups/sauces (HR = 1.10, 95% CI = 1.00-1.22). In ER-PR- tumors, vegetable-oil-based margarine (HR = 1.31, 95% CI = 1.09-1.59)... (More)
We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmö Diet and Cancer cohort (17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR+ tumors, a protective linear risk trend, indicating change between adjoining food categories, was seen with yogurt (HR = 0.89, 95% CI = 0.80-0.99), but increased risks with eggs (HR = 1.10, 95% CI = 1.01-1.20) and dried soups/sauces (HR = 1.10, 95% CI = 1.00-1.22). In ER-PR- tumors, vegetable-oil-based margarine (HR = 1.31, 95% CI = 1.09-1.59) and dried soups/sauces (HR = 1.31 95% CI = 1.05-1.64) showed increased risks. Heterogeneity was observed between ER+PR+ and ER-PR- tumors for vegetable-oil-based margarine (P < 0.01). Regular milk showed decreased, and dried soups/sauces increased, risk with all breast cancer. The study suggests that fat-containing food may contribute both to hormonal and nonhormonal mechanisms in breast tumor development and supports observations of positive associations between characteristics of Westernized diets and postmenopausal breast cancer. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrition and Cancer
volume
63
issue
5
pages
722 - 733
publisher
Lawrence Erlbaum Associates
external identifiers
  • wos:000294370900007
  • pmid:21767080
  • scopus:79960581907
ISSN
1532-7914
DOI
10.1080/01635581.2011.570897
language
English
LU publication?
yes
id
844b5f64-f586-48d9-9e11-931535160c52 (old id 2058541)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21767080?dopt=Abstract
date added to LUP
2011-08-01 12:34:37
date last changed
2017-01-01 07:30:28
@article{844b5f64-f586-48d9-9e11-931535160c52,
  abstract     = {We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmö Diet and Cancer cohort (17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR+ tumors, a protective linear risk trend, indicating change between adjoining food categories, was seen with yogurt (HR = 0.89, 95% CI = 0.80-0.99), but increased risks with eggs (HR = 1.10, 95% CI = 1.01-1.20) and dried soups/sauces (HR = 1.10, 95% CI = 1.00-1.22). In ER-PR- tumors, vegetable-oil-based margarine (HR = 1.31, 95% CI = 1.09-1.59) and dried soups/sauces (HR = 1.31 95% CI = 1.05-1.64) showed increased risks. Heterogeneity was observed between ER+PR+ and ER-PR- tumors for vegetable-oil-based margarine (P &lt; 0.01). Regular milk showed decreased, and dried soups/sauces increased, risk with all breast cancer. The study suggests that fat-containing food may contribute both to hormonal and nonhormonal mechanisms in breast tumor development and supports observations of positive associations between characteristics of Westernized diets and postmenopausal breast cancer.},
  author       = {Wirfält, Elisabet and Li, Cairu and Manjer, Jonas and Ericson, Ulrika and Sonestedt, Emily and Borgquist, Signe and Landberg, Göran and Olsson, Håkan and Gullberg, Bo},
  issn         = {1532-7914},
  language     = {eng},
  number       = {5},
  pages        = {722--733},
  publisher    = {Lawrence Erlbaum Associates},
  series       = {Nutrition and Cancer},
  title        = {Food sources of fat and sex hormone receptor status of invasive breast tumors in women of the malmö diet and cancer cohort.},
  url          = {http://dx.doi.org/10.1080/01635581.2011.570897},
  volume       = {63},
  year         = {2011},
}