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Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study

Langenberg, C.; Sharp, S.; Forouhi, N. G.; Franks, Paul LU ; Schulze, M. B.; Kerrison, N.; Ekelund, U.; Barroso, I.; Panico, S. and Tormo, M. J., et al. (2011) In Diabetologia 54(9). p.2272-2282
Abstract
Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes. Incident cases of type 2 diabetes occurring in European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts between 1991 and 2007 from eight of the ten EPIC countries were ascertained and... (More)
Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes. Incident cases of type 2 diabetes occurring in European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts between 1991 and 2007 from eight of the ten EPIC countries were ascertained and verified. Prentice-weighted Cox regression and random-effects meta-analyses were used to investigate differences in diabetes incidence by age and sex. A total of 12,403 verified incident cases of type 2 diabetes occurred during 3.99 million person-years of follow-up of 340,234 EPIC participants eligible for InterAct. We defined a centre-stratified subcohort of 16,154 individuals for comparative analyses. Individuals with incident diabetes who were randomly selected into the subcohort (n = 778) were included as cases in the analyses. All prevalent diabetes cases were excluded from the study. InterAct cases were followed-up for an average of 6.9 years; 49.7% were men. Mean baseline age and age at diagnosis were 55.6 and 62.5 years, mean BMI and waist circumference values were 29.4 kg/m(2) and 102.7 cm in men, and 30.1 kg/m(2) and 92.8 cm in women, respectively. Risk of type 2 diabetes increased linearly with age, with an overall HR of 1.56 (95% CI 1.48-1.64) for a 10 year age difference, adjusted for sex. A male excess in the risk of incident diabetes was consistently observed across all countries, with a pooled HR of 1.51 (95% CI 1.39-1.64), adjusted for age. InterAct is a large, well-powered, prospective study that will inform our understanding of the interplay between genes and lifestyle factors on the risk of type 2 diabetes development. (Less)
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keywords
Cohort studies, Diabetes mellitus, Epidemiologic research design, Gene-lifestyle interaction, Genetic epidemiology, Type 2 diabetes
in
Diabetologia
volume
54
issue
9
pages
2272 - 2282
publisher
Springer Verlag
external identifiers
  • wos:000293544900012
  • scopus:80054698404
ISSN
1432-0428
DOI
10.1007/s00125-011-2182-9
language
English
LU publication?
yes
id
8172418a-2430-45c9-a582-e5eeb8a1d805 (old id 2071571)
date added to LUP
2011-09-02 08:28:09
date last changed
2017-11-12 03:12:13
@article{8172418a-2430-45c9-a582-e5eeb8a1d805,
  abstract     = {Studying gene-lifestyle interaction may help to identify lifestyle factors that modify genetic susceptibility and uncover genetic loci exerting important subgroup effects. Adequately powered studies with prospective, unbiased, standardised assessment of key behavioural factors for gene-lifestyle studies are lacking. This case-cohort study aims to investigate how genetic and potentially modifiable lifestyle and behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes. Incident cases of type 2 diabetes occurring in European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts between 1991 and 2007 from eight of the ten EPIC countries were ascertained and verified. Prentice-weighted Cox regression and random-effects meta-analyses were used to investigate differences in diabetes incidence by age and sex. A total of 12,403 verified incident cases of type 2 diabetes occurred during 3.99 million person-years of follow-up of 340,234 EPIC participants eligible for InterAct. We defined a centre-stratified subcohort of 16,154 individuals for comparative analyses. Individuals with incident diabetes who were randomly selected into the subcohort (n = 778) were included as cases in the analyses. All prevalent diabetes cases were excluded from the study. InterAct cases were followed-up for an average of 6.9 years; 49.7% were men. Mean baseline age and age at diagnosis were 55.6 and 62.5 years, mean BMI and waist circumference values were 29.4 kg/m(2) and 102.7 cm in men, and 30.1 kg/m(2) and 92.8 cm in women, respectively. Risk of type 2 diabetes increased linearly with age, with an overall HR of 1.56 (95% CI 1.48-1.64) for a 10 year age difference, adjusted for sex. A male excess in the risk of incident diabetes was consistently observed across all countries, with a pooled HR of 1.51 (95% CI 1.39-1.64), adjusted for age. InterAct is a large, well-powered, prospective study that will inform our understanding of the interplay between genes and lifestyle factors on the risk of type 2 diabetes development.},
  author       = {Langenberg, C. and Sharp, S. and Forouhi, N. G. and Franks, Paul and Schulze, M. B. and Kerrison, N. and Ekelund, U. and Barroso, I. and Panico, S. and Tormo, M. J. and Spranger, J. and Griffin, S. and van der Schouw, Y. T. and Amiano, P. and Ardanaz, E. and Arriola, L. and Balkau, B. and Barricarte, A. and Beulens, J. W. J. and Boeing, H. and Bueno-de-Mesquita, H. B. and Buijsse, B. and Chirlaque Lopez, M. D. and Clavel-Chapelon, F. and Crowe, F. L. and de Lauzon-Guillan, B. and Deloukas, P. and Dorronsoro, M. and Drogan, D. and Froguel, P. and Gonzalez, C. and Grioni, S. and Groop, Leif and Groves, C. and Hainaut, P. and Halkjaer, J. and Hallmans, G. and Hansen, T. and Huerta Castano, J. M. and Kaaks, R. and Key, T. J. and Khaw, K. T. and Koulman, A. and Mattiello, A. and Navarro, C. and Nilsson, P and Norat, T. and Overvad, K. and Palla, L. and Palli, D. and Pedersen, O. and Peeters, P. H. and Quiros, J. R. and Ramachandran, A. and Rodriguez-Suarez, L. and Rolandsson, O. and Romaguera, D. and Romieu, I. and Sacerdote, C. and Sanchez, M. J. and Sandbaek, A. and Slimani, N. and Sluijs, I. and Spijkerman, A. M. W. and Teucher, B. and Tjonneland, A. and Tumino, R. and van der A, D. L. and Verschuren, W. M. M. and Tuomilehto, J. and Feskens, E. and McCarthy, M. and Riboli, E. and Wareham, N. J.},
  issn         = {1432-0428},
  keyword      = {Cohort studies,Diabetes mellitus,Epidemiologic research design,Gene-lifestyle interaction,Genetic epidemiology,Type 2 diabetes},
  language     = {eng},
  number       = {9},
  pages        = {2272--2282},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study},
  url          = {http://dx.doi.org/10.1007/s00125-011-2182-9},
  volume       = {54},
  year         = {2011},
}