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A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice.

Axling, Ulrika LU ; Rosén, Liza LU ; Wierup, Nils LU ; Östman, Elin LU ; Björck, Inger LU and Holm, Cecilia LU (2010) In Diabetes, Obesity and Metabolism 12(11). p.976-982
Abstract
AIM: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model. METHODS: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance tests were performed to investigate the effect of the experimental diets on glucose tolerance and insulin resistance. RESULTS: In this study, a high glycaemic diet resulted in impaired oral glucose tolerance compared to a low glycaemic diet. This effect was more pronounced in the group fed a medium-fat diet, suggesting that a lower dietary fat... (More)
AIM: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model. METHODS: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance tests were performed to investigate the effect of the experimental diets on glucose tolerance and insulin resistance. RESULTS: In this study, a high glycaemic diet resulted in impaired oral glucose tolerance compared to a low glycaemic diet. This effect was more pronounced in the group fed a medium-fat diet, suggesting that a lower dietary fat content ameliorates the negative effect of a high glycaemic diet. No effect on body weight or body fat content was observed in either a low-fat diet or a medium-fat diet. Static incubation of isolated islets did not show any differences in basal (3.3 mM glucose) or glucose-stimulated (8.6 and 16.7 mM glucose) insulin secretion between mice fed a low or high glycaemic diet. CONCLUSION: Together, our data suggest that the impaired glucose tolerance seen after a high glycaemic diet is not explained by altered β-cell function. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
body composition, beta-cell, glycaemic control
in
Diabetes, Obesity and Metabolism
volume
12
issue
11
pages
976 - 982
publisher
Wiley-Blackwell
external identifiers
  • wos:000282377100006
  • pmid:20880344
  • scopus:77957272603
  • pmid:20880344
ISSN
1462-8902
DOI
10.1111/j.1463-1326.2010.01288.x
project
ANTIDIABETIC FOOD CENTRE
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuroendocrine Cell Biology (013212008), Molecular Endocrinology (013212018), Applied Nutrition and Food Chemistry (011001300)
id
249fb951-2ac0-4ed2-899a-b83aeabf8c07 (old id 1711613)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/20880344?dopt=Abstract
date added to LUP
2016-04-01 10:53:45
date last changed
2023-09-28 16:50:05
@article{249fb951-2ac0-4ed2-899a-b83aeabf8c07,
  abstract     = {{AIM: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model. METHODS: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance tests were performed to investigate the effect of the experimental diets on glucose tolerance and insulin resistance. RESULTS: In this study, a high glycaemic diet resulted in impaired oral glucose tolerance compared to a low glycaemic diet. This effect was more pronounced in the group fed a medium-fat diet, suggesting that a lower dietary fat content ameliorates the negative effect of a high glycaemic diet. No effect on body weight or body fat content was observed in either a low-fat diet or a medium-fat diet. Static incubation of isolated islets did not show any differences in basal (3.3 mM glucose) or glucose-stimulated (8.6 and 16.7 mM glucose) insulin secretion between mice fed a low or high glycaemic diet. CONCLUSION: Together, our data suggest that the impaired glucose tolerance seen after a high glycaemic diet is not explained by altered β-cell function.}},
  author       = {{Axling, Ulrika and Rosén, Liza and Wierup, Nils and Östman, Elin and Björck, Inger and Holm, Cecilia}},
  issn         = {{1462-8902}},
  keywords     = {{body composition; beta-cell; glycaemic control}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{976--982}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Diabetes, Obesity and Metabolism}},
  title        = {{A low glycaemic diet improves oral glucose tolerance but has no effect on β-cell function in C57BL/6J mice.}},
  url          = {{http://dx.doi.org/10.1111/j.1463-1326.2010.01288.x}},
  doi          = {{10.1111/j.1463-1326.2010.01288.x}},
  volume       = {{12}},
  year         = {{2010}},
}