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Research Paper Impact of combining vitamin C with radiation therapy in human breast cancer : Does it matter?

Khazaei, Somayeh LU ; Nilsson, Linn LU ; Adrian, Gabriel LU orcid ; Tryggvadottir, Helga LU ; Konradsson, Elise LU ; Borgquist, Signe LU ; Isaksson, Karolin LU ; Ceberg, Crister LU orcid and Jernström, Helena LU (2022) In Oncotarget 13(1). p.439-453
Abstract

Vitamin C may impact the efficiency of radiation therapy (RT) in breast cancer. The effects of RT alone or in combination with vitamin C in SKBR3, MDA-MB-231, and MCF7 cells were compared using clonogenic assay, proliferation assay (MTT), cell cycle analysis, and Western blot. Vitamin C use was assessed in 1803 breast cancer patients 2002–2017 in relation to clinicopathological features and recurrences after RT. Vitamin C combined with RT resulted in non-significant increases in colony formation and minor differences in cell cycle arrest and expression of studied proteins, compared to RT alone. Lower vitamin C doses alone or in combination with RT, resulted in higher proliferation with MTT than higher vitamin C doses in a cell... (More)

Vitamin C may impact the efficiency of radiation therapy (RT) in breast cancer. The effects of RT alone or in combination with vitamin C in SKBR3, MDA-MB-231, and MCF7 cells were compared using clonogenic assay, proliferation assay (MTT), cell cycle analysis, and Western blot. Vitamin C use was assessed in 1803 breast cancer patients 2002–2017 in relation to clinicopathological features and recurrences after RT. Vitamin C combined with RT resulted in non-significant increases in colony formation and minor differences in cell cycle arrest and expression of studied proteins, compared to RT alone. Lower vitamin C doses alone or in combination with RT, resulted in higher proliferation with MTT than higher vitamin C doses in a cell line-dependent manner. Vitamin C use was associated with lower histological grade and BMI but not recurrence risk in RT-treated patients (LogRank P = 0.54). Vitamin C impacted RT efficiency differently depending on breast cancer subtype and vitamin C concentration. Lower doses of vitamin C, achievable with oral administration, might increase breast cancer cell proliferation and decrease radiosensitivity. Despite vitamin C users having less aggressive tumors than non-users, the recurrence risk in RT-treated patients was similar in vitamin C users and non-users.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
clinical outcome, human breast cancer, in vitro, radiation therapy, vitamin C
in
Oncotarget
volume
13
issue
1
pages
15 pages
publisher
Impact Journals
external identifiers
  • scopus:85127062809
ISSN
1949-2553
DOI
10.18632/ONCOTARGET.28204
language
English
LU publication?
yes
id
270d579f-356b-4fe6-98a4-0a44478a7de7
date added to LUP
2022-06-03 13:39:21
date last changed
2025-10-14 11:01:11
@article{270d579f-356b-4fe6-98a4-0a44478a7de7,
  abstract     = {{<p>Vitamin C may impact the efficiency of radiation therapy (RT) in breast cancer. The effects of RT alone or in combination with vitamin C in SKBR3, MDA-MB-231, and MCF7 cells were compared using clonogenic assay, proliferation assay (MTT), cell cycle analysis, and Western blot. Vitamin C use was assessed in 1803 breast cancer patients 2002–2017 in relation to clinicopathological features and recurrences after RT. Vitamin C combined with RT resulted in non-significant increases in colony formation and minor differences in cell cycle arrest and expression of studied proteins, compared to RT alone. Lower vitamin C doses alone or in combination with RT, resulted in higher proliferation with MTT than higher vitamin C doses in a cell line-dependent manner. Vitamin C use was associated with lower histological grade and BMI but not recurrence risk in RT-treated patients (LogRank P = 0.54). Vitamin C impacted RT efficiency differently depending on breast cancer subtype and vitamin C concentration. Lower doses of vitamin C, achievable with oral administration, might increase breast cancer cell proliferation and decrease radiosensitivity. Despite vitamin C users having less aggressive tumors than non-users, the recurrence risk in RT-treated patients was similar in vitamin C users and non-users.</p>}},
  author       = {{Khazaei, Somayeh and Nilsson, Linn and Adrian, Gabriel and Tryggvadottir, Helga and Konradsson, Elise and Borgquist, Signe and Isaksson, Karolin and Ceberg, Crister and Jernström, Helena}},
  issn         = {{1949-2553}},
  keywords     = {{clinical outcome; human breast cancer; in vitro; radiation therapy; vitamin C}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{439--453}},
  publisher    = {{Impact Journals}},
  series       = {{Oncotarget}},
  title        = {{Research Paper Impact of combining vitamin C with radiation therapy in human breast cancer : Does it matter?}},
  url          = {{http://dx.doi.org/10.18632/ONCOTARGET.28204}},
  doi          = {{10.18632/ONCOTARGET.28204}},
  volume       = {{13}},
  year         = {{2022}},
}