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No relations between breast cancer risk and fatty acids of erythrocyte membranes in postmenopausal women of the Malmo Diet Cancer cohort (Sweden)

Wirfält, Elisabet LU ; Vessby, B; Mattisson, Iréne LU ; Gullberg, Bo LU ; Olsson, Håkan LU and Berglund, Göran LU (2004) In European Journal of Clinical Nutrition 58(5). p.761-770
Abstract
Objective: To examine the fatty acid composition of erythrocyte membranes, in relation to obesity indexes and breast cancer risk. Design: A nested case-control study. Setting: The Malmo Diet Cancer cohort, Sweden. Subjects: Among women 50 y or older at baseline (n=12803), incident breast cancer cases (n=237) were matched to controls (n=673) on age and screening date. Methods: A diet history method, a structured questionnaire, anthropometrics and blood samples provided data. Analysis included partial correlation coefficients between dietary fatty acids (DFA) and fatty acids of erythrocyte membranes (EFA), and Spearman's rank order correlations between EFA and four obesity indexes. Conditional logistic regression examined breast cancer risks... (More)
Objective: To examine the fatty acid composition of erythrocyte membranes, in relation to obesity indexes and breast cancer risk. Design: A nested case-control study. Setting: The Malmo Diet Cancer cohort, Sweden. Subjects: Among women 50 y or older at baseline (n=12803), incident breast cancer cases (n=237) were matched to controls (n=673) on age and screening date. Methods: A diet history method, a structured questionnaire, anthropometrics and blood samples provided data. Analysis included partial correlation coefficients between dietary fatty acids (DFA) and fatty acids of erythrocyte membranes (EFA), and Spearman's rank order correlations between EFA and four obesity indexes. Conditional logistic regression examined breast cancer risks related to EFA. Results: DFA and EFA from fish and milk, and DFA and EFA linoleic acid, show significant positive associations. Relations are negative between indexes of obesity and "milk'' EFA, but positive between indexes of obesity and indexes of delta9- and delta6-desaturase enzyme activity. No significant relations were observed between EFA and breast cancer risk. Conclusions: Similar to other studies, dietary fish and milk fatty acids, and linoleic acid, are related to the corresponding EFA. Breast cancer risk was not significantly related to EFA in this study. However, the findings suggest positive relations between body mass index, body fat per cent and indexes of desaturase activity, and negative relations between central obesity and milk EFA. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer, postmenopausal breast, dietary biomarkers, erythrocyte, fatty acids, prospective study
in
European Journal of Clinical Nutrition
volume
58
issue
5
pages
761 - 770
publisher
Nature Publishing Group
external identifiers
  • pmid:15116079
  • wos:000221068700008
  • scopus:2642525961
ISSN
1476-5640
DOI
10.1038/sj.ejcn.1601874
language
English
LU publication?
yes
id
2d6a7cd5-41c2-483a-a53f-b0854e46b69c (old id 280482)
date added to LUP
2007-10-26 10:03:43
date last changed
2017-01-01 07:14:38
@article{2d6a7cd5-41c2-483a-a53f-b0854e46b69c,
  abstract     = {Objective: To examine the fatty acid composition of erythrocyte membranes, in relation to obesity indexes and breast cancer risk. Design: A nested case-control study. Setting: The Malmo Diet Cancer cohort, Sweden. Subjects: Among women 50 y or older at baseline (n=12803), incident breast cancer cases (n=237) were matched to controls (n=673) on age and screening date. Methods: A diet history method, a structured questionnaire, anthropometrics and blood samples provided data. Analysis included partial correlation coefficients between dietary fatty acids (DFA) and fatty acids of erythrocyte membranes (EFA), and Spearman's rank order correlations between EFA and four obesity indexes. Conditional logistic regression examined breast cancer risks related to EFA. Results: DFA and EFA from fish and milk, and DFA and EFA linoleic acid, show significant positive associations. Relations are negative between indexes of obesity and "milk'' EFA, but positive between indexes of obesity and indexes of delta9- and delta6-desaturase enzyme activity. No significant relations were observed between EFA and breast cancer risk. Conclusions: Similar to other studies, dietary fish and milk fatty acids, and linoleic acid, are related to the corresponding EFA. Breast cancer risk was not significantly related to EFA in this study. However, the findings suggest positive relations between body mass index, body fat per cent and indexes of desaturase activity, and negative relations between central obesity and milk EFA.},
  author       = {Wirfält, Elisabet and Vessby, B and Mattisson, Iréne and Gullberg, Bo and Olsson, Håkan and Berglund, Göran},
  issn         = {1476-5640},
  keyword      = {cancer,postmenopausal breast,dietary biomarkers,erythrocyte,fatty acids,prospective study},
  language     = {eng},
  number       = {5},
  pages        = {761--770},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {No relations between breast cancer risk and fatty acids of erythrocyte membranes in postmenopausal women of the Malmo Diet Cancer cohort (Sweden)},
  url          = {http://dx.doi.org/10.1038/sj.ejcn.1601874},
  volume       = {58},
  year         = {2004},
}