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A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects

Tovar, Juscelino LU ; Nilsson, Anne LU orcid ; Johansson, Maria LU ; Ekesbo, Rickard LU ; Aberg, Ann-Margreth ; Johansson, Ulla and Björck, Inger LU (2012) In Nutrition & Metabolism 9(29).
Abstract
Background: Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD). Methods: Fourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting glycemia <= 6.1 mmol/L) participated in a randomized crossover intervention comparing a multifunctional (active) diet (AD) with a control diet (CD) devoid of the "active" components. Each diet was consumed during 4 wk with a 4 wk washout period. AD included the following functional concepts: low glycemic impact meals, antioxidant-rich foods,... (More)
Background: Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD). Methods: Fourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting glycemia <= 6.1 mmol/L) participated in a randomized crossover intervention comparing a multifunctional (active) diet (AD) with a control diet (CD) devoid of the "active" components. Each diet was consumed during 4 wk with a 4 wk washout period. AD included the following functional concepts: low glycemic impact meals, antioxidant-rich foods, oily fish as source of long-chain omega-3 fatty acids, viscous dietary fibers, soybean and whole barley kernel products, almonds, stanols and a probiotic strain (Lactobacillus plantarum Heal19/DSM15313). Results: Although the aim was to improve metabolic markers without promoting body weight loss, minor weight reductions were observed with both diets (0.9-1.8 +/- 0.2%; P < 0.05). CD did not modify the metabolic variables measured. AD promoted significant changes in total serum cholesterol (-26 +/- 1% vs baseline; P < 0.0001), LDL-cholesterol (-34 +/- 1%; P < 0.0001), triglycerides (-19 +/- 3%; P = 0.0056), LDL/HDL (-27 +/- 2%; P < 0.0001), apoB/apoA1 (-10 +/- 2%; P < 0.0001), HbA1c (-2 +/- 0.4%; P = 0.0013), hs-CRP (-29 +/- 9%; P = 0.0497) and systolic blood pressure (-8 +/- 1%, P = 0.0123). The differences remained significant after adjustment for weight change. After AD, the Framingham cardiovascular risk estimate was 30 +/- 4% (P < 0.0001) lower and the Reynolds cardiovascular risk score, which considers CRP values, decreased by 35 +/- 3% (P < 0.0001). Conclusion: The improved biomarker levels recorded in healthy individuals following the multifunctional regime suggest preventive potential of this dietary approach against CMD. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiometabolic disease, metabolic syndrome, dietary prevention, functional foods, randomized controlled trial, crossover design
in
Nutrition & Metabolism
volume
9
issue
29
publisher
BioMed Central (BMC)
external identifiers
  • wos:000304541400001
  • scopus:84859139090
  • pmid:22472183
ISSN
1743-7075
DOI
10.1186/1743-7075-9-29
project
ANTIDIABETIC FOOD CENTRE
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Family Medicine (013241010), Applied Nutrition and Food Chemistry (011001300), Food for Health Science Centre, Medicon Village (016630312), Food for Health Science Centre (016630311)
id
5c71082c-bcfb-4ab3-8dfa-0ed1a4c46335 (old id 2809710)
date added to LUP
2016-04-01 14:36:10
date last changed
2023-11-05 03:00:10
@article{5c71082c-bcfb-4ab3-8dfa-0ed1a4c46335,
  abstract     = {{Background: Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD). Methods: Fourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting glycemia &lt;= 6.1 mmol/L) participated in a randomized crossover intervention comparing a multifunctional (active) diet (AD) with a control diet (CD) devoid of the "active" components. Each diet was consumed during 4 wk with a 4 wk washout period. AD included the following functional concepts: low glycemic impact meals, antioxidant-rich foods, oily fish as source of long-chain omega-3 fatty acids, viscous dietary fibers, soybean and whole barley kernel products, almonds, stanols and a probiotic strain (Lactobacillus plantarum Heal19/DSM15313). Results: Although the aim was to improve metabolic markers without promoting body weight loss, minor weight reductions were observed with both diets (0.9-1.8 +/- 0.2%; P &lt; 0.05). CD did not modify the metabolic variables measured. AD promoted significant changes in total serum cholesterol (-26 +/- 1% vs baseline; P &lt; 0.0001), LDL-cholesterol (-34 +/- 1%; P &lt; 0.0001), triglycerides (-19 +/- 3%; P = 0.0056), LDL/HDL (-27 +/- 2%; P &lt; 0.0001), apoB/apoA1 (-10 +/- 2%; P &lt; 0.0001), HbA1c (-2 +/- 0.4%; P = 0.0013), hs-CRP (-29 +/- 9%; P = 0.0497) and systolic blood pressure (-8 +/- 1%, P = 0.0123). The differences remained significant after adjustment for weight change. After AD, the Framingham cardiovascular risk estimate was 30 +/- 4% (P &lt; 0.0001) lower and the Reynolds cardiovascular risk score, which considers CRP values, decreased by 35 +/- 3% (P &lt; 0.0001). Conclusion: The improved biomarker levels recorded in healthy individuals following the multifunctional regime suggest preventive potential of this dietary approach against CMD.}},
  author       = {{Tovar, Juscelino and Nilsson, Anne and Johansson, Maria and Ekesbo, Rickard and Aberg, Ann-Margreth and Johansson, Ulla and Björck, Inger}},
  issn         = {{1743-7075}},
  keywords     = {{Cardiometabolic disease; metabolic syndrome; dietary prevention; functional foods; randomized controlled trial; crossover design}},
  language     = {{eng}},
  number       = {{29}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Nutrition & Metabolism}},
  title        = {{A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects}},
  url          = {{https://lup.lub.lu.se/search/files/4062054/3458615.pdf}},
  doi          = {{10.1186/1743-7075-9-29}},
  volume       = {{9}},
  year         = {{2012}},
}