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A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects

Tovar, Juscelino LU ; Nilsson, Anne LU ; Johansson, Maria LU ; Ekesbo, Rickard LU ; Aberg, Ann-Margreth; Johansson, Ulla and Björck, Inger LU (2012) In Nutrition & Metabolism 9(29).
Abstract
Background: Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD). Methods: Fourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting glycemia <= 6.1 mmol/L) participated in a randomized crossover intervention comparing a multifunctional (active) diet (AD) with a control diet (CD) devoid of the "active" components. Each diet was consumed during 4 wk with a 4 wk washout period. AD included the following functional concepts: low glycemic impact meals, antioxidant-rich foods,... (More)
Background: Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD). Methods: Fourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting glycemia <= 6.1 mmol/L) participated in a randomized crossover intervention comparing a multifunctional (active) diet (AD) with a control diet (CD) devoid of the "active" components. Each diet was consumed during 4 wk with a 4 wk washout period. AD included the following functional concepts: low glycemic impact meals, antioxidant-rich foods, oily fish as source of long-chain omega-3 fatty acids, viscous dietary fibers, soybean and whole barley kernel products, almonds, stanols and a probiotic strain (Lactobacillus plantarum Heal19/DSM15313). Results: Although the aim was to improve metabolic markers without promoting body weight loss, minor weight reductions were observed with both diets (0.9-1.8 +/- 0.2%; P < 0.05). CD did not modify the metabolic variables measured. AD promoted significant changes in total serum cholesterol (-26 +/- 1% vs baseline; P < 0.0001), LDL-cholesterol (-34 +/- 1%; P < 0.0001), triglycerides (-19 +/- 3%; P = 0.0056), LDL/HDL (-27 +/- 2%; P < 0.0001), apoB/apoA1 (-10 +/- 2%; P < 0.0001), HbA1c (-2 +/- 0.4%; P = 0.0013), hs-CRP (-29 +/- 9%; P = 0.0497) and systolic blood pressure (-8 +/- 1%, P = 0.0123). The differences remained significant after adjustment for weight change. After AD, the Framingham cardiovascular risk estimate was 30 +/- 4% (P < 0.0001) lower and the Reynolds cardiovascular risk score, which considers CRP values, decreased by 35 +/- 3% (P < 0.0001). Conclusion: The improved biomarker levels recorded in healthy individuals following the multifunctional regime suggest preventive potential of this dietary approach against CMD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiometabolic disease, metabolic syndrome, dietary prevention, functional foods, randomized controlled trial, crossover design
in
Nutrition & Metabolism
volume
9
issue
29
publisher
BioMed Central
external identifiers
  • wos:000304541400001
  • scopus:84859139090
ISSN
1743-7075
DOI
10.1186/1743-7075-9-29
language
English
LU publication?
yes
id
5c71082c-bcfb-4ab3-8dfa-0ed1a4c46335 (old id 2809710)
date added to LUP
2012-06-28 16:33:30
date last changed
2017-08-13 04:07:39
@article{5c71082c-bcfb-4ab3-8dfa-0ed1a4c46335,
  abstract     = {Background: Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD). Methods: Fourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting glycemia &lt;= 6.1 mmol/L) participated in a randomized crossover intervention comparing a multifunctional (active) diet (AD) with a control diet (CD) devoid of the "active" components. Each diet was consumed during 4 wk with a 4 wk washout period. AD included the following functional concepts: low glycemic impact meals, antioxidant-rich foods, oily fish as source of long-chain omega-3 fatty acids, viscous dietary fibers, soybean and whole barley kernel products, almonds, stanols and a probiotic strain (Lactobacillus plantarum Heal19/DSM15313). Results: Although the aim was to improve metabolic markers without promoting body weight loss, minor weight reductions were observed with both diets (0.9-1.8 +/- 0.2%; P &lt; 0.05). CD did not modify the metabolic variables measured. AD promoted significant changes in total serum cholesterol (-26 +/- 1% vs baseline; P &lt; 0.0001), LDL-cholesterol (-34 +/- 1%; P &lt; 0.0001), triglycerides (-19 +/- 3%; P = 0.0056), LDL/HDL (-27 +/- 2%; P &lt; 0.0001), apoB/apoA1 (-10 +/- 2%; P &lt; 0.0001), HbA1c (-2 +/- 0.4%; P = 0.0013), hs-CRP (-29 +/- 9%; P = 0.0497) and systolic blood pressure (-8 +/- 1%, P = 0.0123). The differences remained significant after adjustment for weight change. After AD, the Framingham cardiovascular risk estimate was 30 +/- 4% (P &lt; 0.0001) lower and the Reynolds cardiovascular risk score, which considers CRP values, decreased by 35 +/- 3% (P &lt; 0.0001). Conclusion: The improved biomarker levels recorded in healthy individuals following the multifunctional regime suggest preventive potential of this dietary approach against CMD.},
  author       = {Tovar, Juscelino and Nilsson, Anne and Johansson, Maria and Ekesbo, Rickard and Aberg, Ann-Margreth and Johansson, Ulla and Björck, Inger},
  issn         = {1743-7075},
  keyword      = {Cardiometabolic disease,metabolic syndrome,dietary prevention,functional foods,randomized controlled trial,crossover design},
  language     = {eng},
  number       = {29},
  publisher    = {BioMed Central},
  series       = {Nutrition & Metabolism},
  title        = {A diet based on multiple functional concepts improves cardiometabolic risk parameters in healthy subjects},
  url          = {http://dx.doi.org/10.1186/1743-7075-9-29},
  volume       = {9},
  year         = {2012},
}