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Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Zamora-Ros, Raul; Agudo, Antonio; Lujan-Barroso, Leila; Romieu, Isabelle; Ferrari, Pietro; Knaze, Viktoria; Bueno-de-Mesquita, H. Bas; Leenders, Max; Travis, Ruth C. and Navarro, Carmen, et al. (2012) In American Journal of Clinical Nutrition 96(6). p.1398-1408
Abstract
Background: Several experimental studies have suggested potential anticarcinogenic effects of flavonoids, although epidemiologic evidence for the impact of dietary flavonoids on risk of gastric cancer (GC) is limited. Objective: We investigated the association between intake of dietary flavonoids and lignans and incident GC. Design: The study followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European countries who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Validated dietary questionnaires and lifestyle information were collected at baseline. A food-composition database on flavonoids and lignans was compiled by using data from USDA and Phenol-Explorer databases. Results: During an... (More)
Background: Several experimental studies have suggested potential anticarcinogenic effects of flavonoids, although epidemiologic evidence for the impact of dietary flavonoids on risk of gastric cancer (GC) is limited. Objective: We investigated the association between intake of dietary flavonoids and lignans and incident GC. Design: The study followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European countries who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Validated dietary questionnaires and lifestyle information were collected at baseline. A food-composition database on flavonoids and lignans was compiled by using data from USDA and Phenol-Explorer databases. Results: During an average follow-up of 11 y, 683 incident GC cases (57.8% men) were mostly validated by a panel of pathologists and used in this analysis. We observed a significant inverse association between total flavonoid intake and GC risk in women (HR: 0.81; 95% CI: 0.70, 0.94; for the continuous variable after log2 transformation) but not in men (HR: 0.97; 95% CI: 0.85, 1.09). in women, significant inverse associations with GC risk were also observed for intakes of some flavonoid subgroups (anthocyanidins, flavonols, flavones, and flavanols), particularly with intestinal type tumors for total flavonoid and flavanol intakes (P-heterogeneity < 0.1). After stratification by smoking status and sex, there was no significant heterogeneity in these associations between ever- and never-smokers. Conclusion: Total dietary flavonoid intake is associated with a significant reduction in the risk of GC in women. Am J Clin Nutr 2012;96:1398-408. (Less)
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American Journal of Clinical Nutrition
volume
96
issue
6
pages
1398 - 1408
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000311533300018
  • scopus:84869843035
ISSN
1938-3207
DOI
10.3945/ajcn.112.037358
language
English
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yes
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0632cf24-a582-477a-a5ae-8fcb38371ea6 (old id 3372626)
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2013-02-01 07:00:03
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2017-09-17 06:41:42
@article{0632cf24-a582-477a-a5ae-8fcb38371ea6,
  abstract     = {Background: Several experimental studies have suggested potential anticarcinogenic effects of flavonoids, although epidemiologic evidence for the impact of dietary flavonoids on risk of gastric cancer (GC) is limited. Objective: We investigated the association between intake of dietary flavonoids and lignans and incident GC. Design: The study followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European countries who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Validated dietary questionnaires and lifestyle information were collected at baseline. A food-composition database on flavonoids and lignans was compiled by using data from USDA and Phenol-Explorer databases. Results: During an average follow-up of 11 y, 683 incident GC cases (57.8% men) were mostly validated by a panel of pathologists and used in this analysis. We observed a significant inverse association between total flavonoid intake and GC risk in women (HR: 0.81; 95% CI: 0.70, 0.94; for the continuous variable after log2 transformation) but not in men (HR: 0.97; 95% CI: 0.85, 1.09). in women, significant inverse associations with GC risk were also observed for intakes of some flavonoid subgroups (anthocyanidins, flavonols, flavones, and flavanols), particularly with intestinal type tumors for total flavonoid and flavanol intakes (P-heterogeneity &lt; 0.1). After stratification by smoking status and sex, there was no significant heterogeneity in these associations between ever- and never-smokers. Conclusion: Total dietary flavonoid intake is associated with a significant reduction in the risk of GC in women. Am J Clin Nutr 2012;96:1398-408.},
  author       = {Zamora-Ros, Raul and Agudo, Antonio and Lujan-Barroso, Leila and Romieu, Isabelle and Ferrari, Pietro and Knaze, Viktoria and Bueno-de-Mesquita, H. Bas and Leenders, Max and Travis, Ruth C. and Navarro, Carmen and Sanchez-Cantalejo, Emilio and Slimani, Nadia and Scalbert, Augustin and Fedirko, Veronika and Hjartaker, Anette and Engeset, Dagrun and Skeie, Guri and Boeing, Heiner and Foerster, Jana and Li, Kuanrong and Teuchet, Birgit and Agnoli, Claudia and Tumino, Rosario and Mattiello, Amalia and Saieva, Calogero and Johansson, Ingegerd and Stenling, Roger and Luisa Redondo, Maria and Wallström, Peter and Ericson, Ulrika and Khaw, Kay-Tee and Mulligan, Angela A. and Trichopoulou, Antonia and Dilis, Vardis and Katsoulis, Michael and Peeters, Petra H. M. and Igali, Lazslo and Tjonneland, Anne and Halkjaer, Jytte and Touillaud, Marina and Perquier, Florence and Fagherazzi, Guy and Amiano, Pilar and Ardanaz, Eva and Bredsdorff, Lea and Overvad, Kim and Ricceri, Fulvio and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {1938-3207},
  language     = {eng},
  number       = {6},
  pages        = {1398--1408},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study},
  url          = {http://dx.doi.org/10.3945/ajcn.112.037358},
  volume       = {96},
  year         = {2012},
}