Advanced

Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study

Nilsson, Anne LU ; Radeborg, Karl LU ; Salo, Ilkka LU and Björck, Inger LU (2012) In Nutrition Journal 11.
Abstract
Background: Higher plasma n-3 polyunsaturated fatty acids (PUFA) have been associated with a lower risk of age related cognitive decline, and to beneficially affect cardiometabolic risk factors. A relation exists between metabolic disorders such as diabetes type 2 and cognitive decline. Results regarding the potential effects of n-3 PUFA on risk factors in healthy subjects are divergent, and studies regarding the possible relation between cardiometabolic parameters and cognitive performance are scarce. The objective was to evaluate the effects of five weeks intake of long chain n-3 PUFA on cognitive performance in healthy individuals, and to exploit the possible relation between outcomes in cognitive tests to cardiometabolic risk... (More)
Background: Higher plasma n-3 polyunsaturated fatty acids (PUFA) have been associated with a lower risk of age related cognitive decline, and to beneficially affect cardiometabolic risk factors. A relation exists between metabolic disorders such as diabetes type 2 and cognitive decline. Results regarding the potential effects of n-3 PUFA on risk factors in healthy subjects are divergent, and studies regarding the possible relation between cardiometabolic parameters and cognitive performance are scarce. The objective was to evaluate the effects of five weeks intake of long chain n-3 PUFA on cognitive performance in healthy individuals, and to exploit the possible relation between outcomes in cognitive tests to cardiometabolic risk parameters. Methods: Fish oil n-3 PUFA (3g daily) were consumed during 5weeks separated by a 5 week washout period in a cross-over placebo controlled study, including 40 healthy middle aged to elderly subjects. Cognitive performance was determined by tests measuring working memory (WM) and selective attention. Results: Supplementation with n-3 PUFA resulted in better performance in the WM-test compared with placebo (p < 0.05). In contrast to placebo, n-3 PUFA lowered plasma triacylglycerides (P < 0.05) and systolic blood pressure (p < 0.0001). Systolic blood pressure (p < 0.05), f-glucose (p = 0.05), and s-TNF-alpha (p = 0.05), were inversely related to the performance in cognitive tests. Conclusions: Intake of n-3 PUFA improved cognitive performance in healthy subjects after five weeks compared with placebo. In addition, inverse relations were obtained between cardiometabolic risk factors and cognitive performance, indicating a potential of dietary prevention strategies to delay onset of metabolic disorders and associated cognitive decline. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Omega-3 PUFA, DHA, EPA, Fish oil, Dietary prevention, Cognitive, performance, Working memory, Metabolic disorders, Ageing
in
Nutrition Journal
volume
11
publisher
BioMed Central
external identifiers
  • wos:000314520900001
  • scopus:84869868735
ISSN
1475-2891
DOI
10.1186/1475-2891-11-99
language
English
LU publication?
yes
id
f44926dc-67ee-4228-badb-9554f498a790 (old id 3683612)
date added to LUP
2013-04-23 11:10:11
date last changed
2017-10-08 03:58:39
@article{f44926dc-67ee-4228-badb-9554f498a790,
  abstract     = {Background: Higher plasma n-3 polyunsaturated fatty acids (PUFA) have been associated with a lower risk of age related cognitive decline, and to beneficially affect cardiometabolic risk factors. A relation exists between metabolic disorders such as diabetes type 2 and cognitive decline. Results regarding the potential effects of n-3 PUFA on risk factors in healthy subjects are divergent, and studies regarding the possible relation between cardiometabolic parameters and cognitive performance are scarce. The objective was to evaluate the effects of five weeks intake of long chain n-3 PUFA on cognitive performance in healthy individuals, and to exploit the possible relation between outcomes in cognitive tests to cardiometabolic risk parameters. Methods: Fish oil n-3 PUFA (3g daily) were consumed during 5weeks separated by a 5 week washout period in a cross-over placebo controlled study, including 40 healthy middle aged to elderly subjects. Cognitive performance was determined by tests measuring working memory (WM) and selective attention. Results: Supplementation with n-3 PUFA resulted in better performance in the WM-test compared with placebo (p &lt; 0.05). In contrast to placebo, n-3 PUFA lowered plasma triacylglycerides (P &lt; 0.05) and systolic blood pressure (p &lt; 0.0001). Systolic blood pressure (p &lt; 0.05), f-glucose (p = 0.05), and s-TNF-alpha (p = 0.05), were inversely related to the performance in cognitive tests. Conclusions: Intake of n-3 PUFA improved cognitive performance in healthy subjects after five weeks compared with placebo. In addition, inverse relations were obtained between cardiometabolic risk factors and cognitive performance, indicating a potential of dietary prevention strategies to delay onset of metabolic disorders and associated cognitive decline.},
  articleno    = {99},
  author       = {Nilsson, Anne and Radeborg, Karl and Salo, Ilkka and Björck, Inger},
  issn         = {1475-2891},
  keyword      = {Omega-3 PUFA,DHA,EPA,Fish oil,Dietary prevention,Cognitive,performance,Working memory,Metabolic disorders,Ageing},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {Nutrition Journal},
  title        = {Effects of supplementation with n-3 polyunsaturated fatty acids on cognitive performance and cardiometabolic risk markers in healthy 51 to 72 years old subjects: a randomized controlled cross-over study},
  url          = {http://dx.doi.org/10.1186/1475-2891-11-99},
  volume       = {11},
  year         = {2012},
}