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Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.

Spégel, Peter LU ; Lindqvist, Andreas LU ; Sandberg, Monica and Wierup, Nils LU (2014) In Regulatory Peptides 189. p.11-16
Abstract
Hypersecretion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has been associated with obesity and glucose intolerance. This condition has been suggested to be linked to GIP resistance. Besides its insulinotropic effect, GIP also directly affects glucose uptake and lipid metabolism. This notwithstanding, effects of GIP on other circulating metabolites than glucose have not been thoroughly investigated. Here, we examined effects of infusion of various concentrations of GIP in normo- and hyperglycemic rats on serum metabolite profiles. We found that, despite a decrease in serum glucose levels (-26%, p<0.01), the serum metabolite profile was largely unaffected by GIP infusion in normoglycemic rats.... (More)
Hypersecretion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has been associated with obesity and glucose intolerance. This condition has been suggested to be linked to GIP resistance. Besides its insulinotropic effect, GIP also directly affects glucose uptake and lipid metabolism. This notwithstanding, effects of GIP on other circulating metabolites than glucose have not been thoroughly investigated. Here, we examined effects of infusion of various concentrations of GIP in normo- and hyperglycemic rats on serum metabolite profiles. We found that, despite a decrease in serum glucose levels (-26%, p<0.01), the serum metabolite profile was largely unaffected by GIP infusion in normoglycemic rats. Interestingly, levels of branched chain amino acids and the ketone body β-hydroxybutyrate were decreased by 21% (p<0.05) and 27% (p<0.001), respectively, in hyperglycemic rats infused with 60ng/ml GIP. Hence, our data suggest that GIP provokes a decrease in BCAA levels and ketone body production. Increased concentrations of these metabolites have been associated with obesity and T2D. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Regulatory Peptides
volume
189
pages
11 - 16
publisher
Elsevier
external identifiers
  • pmid:24412429
  • wos:000336472800003
  • scopus:84893350728
  • pmid:24412429
ISSN
1873-1686
DOI
10.1016/j.regpep.2013.12.009
language
English
LU publication?
yes
id
70268f00-4b00-45c8-9650-6518f2cb0e3d (old id 4291602)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24412429?dopt=Abstract
date added to LUP
2016-04-01 09:58:21
date last changed
2022-01-25 18:32:26
@article{70268f00-4b00-45c8-9650-6518f2cb0e3d,
  abstract     = {{Hypersecretion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has been associated with obesity and glucose intolerance. This condition has been suggested to be linked to GIP resistance. Besides its insulinotropic effect, GIP also directly affects glucose uptake and lipid metabolism. This notwithstanding, effects of GIP on other circulating metabolites than glucose have not been thoroughly investigated. Here, we examined effects of infusion of various concentrations of GIP in normo- and hyperglycemic rats on serum metabolite profiles. We found that, despite a decrease in serum glucose levels (-26%, p&lt;0.01), the serum metabolite profile was largely unaffected by GIP infusion in normoglycemic rats. Interestingly, levels of branched chain amino acids and the ketone body β-hydroxybutyrate were decreased by 21% (p&lt;0.05) and 27% (p&lt;0.001), respectively, in hyperglycemic rats infused with 60ng/ml GIP. Hence, our data suggest that GIP provokes a decrease in BCAA levels and ketone body production. Increased concentrations of these metabolites have been associated with obesity and T2D.}},
  author       = {{Spégel, Peter and Lindqvist, Andreas and Sandberg, Monica and Wierup, Nils}},
  issn         = {{1873-1686}},
  language     = {{eng}},
  pages        = {{11--16}},
  publisher    = {{Elsevier}},
  series       = {{Regulatory Peptides}},
  title        = {{Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.}},
  url          = {{http://dx.doi.org/10.1016/j.regpep.2013.12.009}},
  doi          = {{10.1016/j.regpep.2013.12.009}},
  volume       = {{189}},
  year         = {{2014}},
}