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Serum concentrations of perfluorinated alkyl acids and their associations with diet and personal characteristics among Swedish adults

Bjermo, Helena ; Darnerud, Per Ola ; Pearson, Monika ; Barbieri, Helene Enghardt ; Lindroos, Anna Karin ; Nalsen, Cecilia ; Lindh, Christian LU orcid ; Jönsson, Bo A LU and Glynn, Anders (2013) In Molecular Nutrition and Food Research 57(12). p.2206-2215
Abstract
ScopeIn this study, food is suggested as a major source of human exposure to perfluorinated alkyl acids (PFAA). We investigated relations between serum levels of PFAA in adults and diet/lifestyle factors nationwide in Sweden. Methods and resultsIn 2010-2011, adults (18-80 years, N = 270) recorded their diet for 4 days and answered a food frequency questionnaire. PFAA were measured in blood serum as well as v-3 fatty acids in plasma phospholipids as a biomarker for fish consumption. Higher levels of PFAA were associated with male sex, increased age, and higher education. Women reporting full breastfeeding for 12 months had 32-44% lower levels of perfluorooctane sulfonate, perfluorooctanoic acid, and perfluorohexane sulfonate than women who... (More)
ScopeIn this study, food is suggested as a major source of human exposure to perfluorinated alkyl acids (PFAA). We investigated relations between serum levels of PFAA in adults and diet/lifestyle factors nationwide in Sweden. Methods and resultsIn 2010-2011, adults (18-80 years, N = 270) recorded their diet for 4 days and answered a food frequency questionnaire. PFAA were measured in blood serum as well as v-3 fatty acids in plasma phospholipids as a biomarker for fish consumption. Higher levels of PFAA were associated with male sex, increased age, and higher education. Women reporting full breastfeeding for 12 months had 32-44% lower levels of perfluorooctane sulfonate, perfluorooctanoic acid, and perfluorohexane sulfonate than women who never nursed their infants full-time. Serum perfluorooctane sulfonate, perfluorononanoic acid, perfluorodecanoic acid, and perfluoroundecanoic acid were positively related to n-3 fatty acids in plasma (partial r = 0.19-0.34, p 0.05). ConclusionThe relatively strong correlations between biomarkers of fish consumption and certain PFAA suggest that PFAA exposure should be taken into account in health risk and benefit assessment of fish consumption. Breastfeeding appears to be a major source of elimination of certain PFAA among women, and consequently PFAA exposure of nursed infants could be significant. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breastfeeding, Diet, Fish intake, Perfluorinated compounds, PFAA
in
Molecular Nutrition and Food Research
volume
57
issue
12
pages
2206 - 2215
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000329945100012
  • scopus:84889019235
  • pmid:23934649
ISSN
1613-4133
DOI
10.1002/mnfr.201200845
language
English
LU publication?
yes
id
587f5c81-9acb-4013-b943-d9f453e8d1b8 (old id 4319282)
date added to LUP
2016-04-01 10:00:56
date last changed
2022-04-27 17:45:55
@article{587f5c81-9acb-4013-b943-d9f453e8d1b8,
  abstract     = {{ScopeIn this study, food is suggested as a major source of human exposure to perfluorinated alkyl acids (PFAA). We investigated relations between serum levels of PFAA in adults and diet/lifestyle factors nationwide in Sweden. Methods and resultsIn 2010-2011, adults (18-80 years, N = 270) recorded their diet for 4 days and answered a food frequency questionnaire. PFAA were measured in blood serum as well as v-3 fatty acids in plasma phospholipids as a biomarker for fish consumption. Higher levels of PFAA were associated with male sex, increased age, and higher education. Women reporting full breastfeeding for 12 months had 32-44% lower levels of perfluorooctane sulfonate, perfluorooctanoic acid, and perfluorohexane sulfonate than women who never nursed their infants full-time. Serum perfluorooctane sulfonate, perfluorononanoic acid, perfluorodecanoic acid, and perfluoroundecanoic acid were positively related to n-3 fatty acids in plasma (partial r = 0.19-0.34, p 0.05). ConclusionThe relatively strong correlations between biomarkers of fish consumption and certain PFAA suggest that PFAA exposure should be taken into account in health risk and benefit assessment of fish consumption. Breastfeeding appears to be a major source of elimination of certain PFAA among women, and consequently PFAA exposure of nursed infants could be significant.}},
  author       = {{Bjermo, Helena and Darnerud, Per Ola and Pearson, Monika and Barbieri, Helene Enghardt and Lindroos, Anna Karin and Nalsen, Cecilia and Lindh, Christian and Jönsson, Bo A and Glynn, Anders}},
  issn         = {{1613-4133}},
  keywords     = {{Breastfeeding; Diet; Fish intake; Perfluorinated compounds; PFAA}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2206--2215}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Molecular Nutrition and Food Research}},
  title        = {{Serum concentrations of perfluorinated alkyl acids and their associations with diet and personal characteristics among Swedish adults}},
  url          = {{http://dx.doi.org/10.1002/mnfr.201200845}},
  doi          = {{10.1002/mnfr.201200845}},
  volume       = {{57}},
  year         = {{2013}},
}