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Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women.

Garg, Gaurav LU ; Kumar, Jitender LU ; McGuigan, Fiona LU ; Ridderstråle, Martin LU ; Gerdhem, Paul LU ; Luthman, Holger LU and Åkesson, Kristina LU (2014) In PLoS ONE 9(2).
Abstract
Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044). Body mass index... (More)
Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044). Body mass index (BMI), total body fat and lean mass were strongly positively correlated with QUS and BMD in both cohorts (r(2) = 0.2-0.6). MC4R rs17782313 was associated with QUS in the OPRA cohort and individuals with the minor C-allele had higher values compared to T-allele homozygotes (TT vs. CT vs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
2
publisher
Public Library of Science
external identifiers
  • pmid:24516669
  • wos:000330830700077
  • scopus:84895535167
ISSN
1932-6203
DOI
10.1371/journal.pone.0088565
language
English
LU publication?
yes
id
6c15cb1d-c143-4562-90df-ce8945e09829 (old id 4334884)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24516669?dopt=Abstract
date added to LUP
2014-03-06 11:06:59
date last changed
2017-01-01 05:45:19
@article{6c15cb1d-c143-4562-90df-ce8945e09829,
  abstract     = {Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vitamin B12) for obesity and osteoporosis. Five common variants: rs17782313 and rs1770633 (melanocortin 4 receptor (MC4R); rs7566605 (insulin induced gene 2 (INSIG2); rs9939609 and rs1121980 (fat mass and obesity associated (FTO) were genotyped in 2 cohorts of Swedish women: PEAK-25 (age 25, n = 1061) and OPRA (age 75, n = 1044). Body mass index (BMI), total body fat and lean mass were strongly positively correlated with QUS and BMD in both cohorts (r(2) = 0.2-0.6). MC4R rs17782313 was associated with QUS in the OPRA cohort and individuals with the minor C-allele had higher values compared to T-allele homozygotes (TT vs. CT vs.},
  articleno    = {e88565},
  author       = {Garg, Gaurav and Kumar, Jitender and McGuigan, Fiona and Ridderstråle, Martin and Gerdhem, Paul and Luthman, Holger and Åkesson, Kristina},
  issn         = {1932-6203},
  language     = {eng},
  number       = {2},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Variation in the MC4R Gene Is Associated with Bone Phenotypes in Elderly Swedish Women.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0088565},
  volume       = {9},
  year         = {2014},
}